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Q4JU85 (Q4JU85_CORJK) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
4-hydroxy-3-methylbut-2-enyl diphosphate reductase HAMAP MF_00191
EC=1.17.1.2 HAMAP MF_00191
Gene names
Name:ispH HAMAP MF_00191 EMBL CAI37622.1
Ordered Locus Names:jk1449
OrganismCorynebacterium jeikeium (strain K411) [Complete proteome] [HAMAP]
Taxonomic identifier306537 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length328 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) By similarity. HAMAP MF_00191 SAAS SAAS003451

Catalytic activity

Dimethylallyl diphosphate + NAD(P)+ + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H. HAMAP MF_00191 SAAS SAAS003451

Isopentenyl diphosphate + NAD(P)+ + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H. HAMAP MF_00191 SAAS SAAS003451

Cofactor

Binds 1 3Fe-4S cluster By similarity. HAMAP MF_00191

Pathway

Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1. HAMAP MF_00191 SAAS SAAS003451

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6. HAMAP MF_00191 SAAS SAAS003451

Sequence similarities

Belongs to the IspH family. HAMAP MF_00191

Sequences

Sequence LengthMass (Da)Tools
Q4JU85 [UniParc].

Last modified August 2, 2005. Version 1.
Checksum: 6A3E00423ECD948B

FASTA32836,012
        10         20         30         40         50         60 
MGHMTTPTTE ATADTKKVYL AAPRGYCAGV DRAVESVEKA LEKHGAPLYV RKEIVHNKHV 

        70         80         90        100        110        120 
VKTFEDRGVI FVDETSEIPR GSNVVFSAHG VSPAVHEEAR QLELKTFDAT CPLVTKVHHE 

       130        140        150        160        170        180 
VTRFAKQGYQ IILIGHHGHE EVEGTAGEAP DVVHLVDGED DVNALEFPEG TKLVWLSQTT 

       190        200        210        220        230        240 
LSVDETMTTV KQLREKFPHI QDPPSDDICY ATQNRQVAVK AIAPKVELMI VVGSQNSSNS 

       250        260        270        280        290        300 
KRLVEVALQH GTQDAHLVDY AEQVDPAWLE GVTHVGVTSG ASVPEILVRG VLELLAEKGY 

       310        320 
GEVEEVTTAT EDLIFSLPRE LRPPRTQK

« Hide

References

[1]"Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora."
Tauch A., Kaiser O., Hain T., Goesmann A., Weisshaar B., Albersmeier A., Bekel T., Bischoff N., Brune I., Chakraborty T., Kalinowski J., Meyer F., Rupp O., Schneiker S., Viehoever P., Puehler A.
J. Bacteriol. 187:4671-4682(2005) [PubMed: 15968079] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K411.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR931997 Genomic DNA. Translation: CAI37622.1.
RefSeqYP_251240.1. NC_007164.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ4JU85.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3432466.
GenomeReviewsGene locus jk1449 in contig CR931997_GR.
KEGGcjk:jk1449.
NMPDRfig|306537.3.peg.589.
PATRIC21513844. VBICorJei31838_1469.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0761.
HOGENOMHBG335228.
OMAAMAPECD.
ProtClustDBPRK01045.

Family and domain databases

HAMAPMF_00191. IspH.
[Tree]
InterProIPR003451. LytB.
[Graphical view]
KOK03527.
PfamPF02401. LYTB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00216. IspH_lytB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ4JU85_CORJK
AccessionPrimary (citable) accession number: Q4JU85
Entry history
Integrated into UniProtKB/TrEMBL: August 2, 2005
Last sequence update: August 2, 2005
Last modified: January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info