Q4JU68 (COAA_CORJK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pantothenate kinase
EC=2.7.1.33

Alternative name(s):
Pantothenic acid kinase

Gene names

Name:	coaA
Ordered Locus Names:	jk1466

Organism

Corynebacterium jeikeium (strain K411) [Complete proteome] [HAMAP]

Taxonomic identifier

306537 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	308 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate. HAMAP MF_00215
Pathway	Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. HAMAP MF_00215
Subcellular location	Cytoplasm Probable HAMAP MF_00215.
Sequence similarities	Belongs to the prokaryotic pantothenate kinase family.

Ontologies

Keywords
Biological process	Coenzyme A biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	coenzyme A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW pantothenate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 308	308	Pantothenate kinase HAMAP MF_00215		PRO_0000325549
Regions
	Nucleotide binding	93 – 100	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q4JU68 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: 586DF57968A42BF7	FASTA	308	35,476
	10 20 30 40 50 60 MDAMTSPSPY IELDRTQWRT LRKSMPQVLT EDELEQLRGI GDEIDLEEVS EVYLPLSRLI 70 80 90 100 110 120 FLRVEAHRRL NAATETFLGE AMPQIPYIIG VCGSVAVGKS TTARVLQVLL QRWETNPRVD 130 140 150 160 170 180 LVTTDGFLLP TAELERRKLM HRKGFPESYD QAELLSFITK VKSGTQKVQA PVYSHEAYDR 190 200 210 220 230 240 IPDQTITVDR PDILIVEGLN VLQTGPTLMV SDLFDFSVYV DARREDIEDW YIDRFLRLKN 250 260 270 280 290 300 TAFKDPEAHF HHFANFSDEE ATVVAREIWQ TVNLPNLMEN ILPTRVRASL VLRKGPDHLV QKVRMRKI

References

[1]

"Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora." Tauch A., Kaiser O., Hain T., Goesmann A., Weisshaar B., Albersmeier A., Bekel T., Bischoff N., Brune I., Chakraborty T., Kalinowski J., Meyer F., Rupp O., Schneiker S., Viehoever P., Puehler A. J. Bacteriol. 187:4671-4682(2005) [PubMed: 15968079] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K411.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR931997 Genomic DNA. Translation: CAI37639.1.
RefSeq	YP_251257.1. NC_007164.1.
3D structure databases
ProteinModelPortal	Q4JU68.
SMR	Q4JU68. Positions 5-308.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4JU68.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3432188.
GenomeReviews	Gene locus jk1466 in contig CR931997_GR.
KEGG	cjk:jk1466.
NMPDR	fig|306537.3.peg.606.
PATRIC	21513878. VBICorJei31838_1486.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1072.
HOGENOM	HBG732538.
OMA	EVYLPLS.
ProtClustDB	PRK05439.
Enzyme and pathway databases
BioCyc	CJEI306537:JK1466-MONOMER.
Family and domain databases
HAMAP	MF_00215. Pantothen_kinase_1. [Tree]
InterPro	IPR004566. PanK_bact. IPR006083. PRK/URK. [Graphical view]
KO	K00867.
PANTHER	PTHR10285:SF7. PanK_bact. 1 hit.
Pfam	PF00485. PRK. 1 hit. [Graphical view]
PIRSF	PIRSF000545. Pantothenate_kin. 1 hit.
TIGRFAMs	TIGR00554. PanK_bact. 1 hit.
ProtoNet	Search...

Entry information

Entry name

COAA_CORJK

Accession

Primary (citable) accession number: Q4JU68

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	August 2, 2005
Last modified:	January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program