Reviewed, UniProtKB/Swiss-Prot Q4JU39 (PTH1_CORJK)

Names and origin

Protein names

Recommended name:
    Peptidyl-tRNA hydrolase 1
      Short name=PTH 1
    EC=3.1.1.29

Gene names

Name:	pth1
Ordered Locus Names:	jk1495

Organism

Corynebacterium jeikeium (strain K411) [Complete proteome] [HAMAP]

Taxonomic identifier

306537 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	193 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis By similarity.
Catalytic activity	N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA. HAMAP MF_00083
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the PTH family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	translation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	aminoacyl-tRNA hydrolase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 193	193	Peptidyl-tRNA hydrolase 1 HAMAP MF_00083		PRO_0000264025

Sequences

	Sequence		Length	Mass (Da)
	Q4JU39-1 [UniParc]. Last modified December 12, 2006. Version 2. Checksum: 8DC188BFC3D5E8B9	FASTA	193	20,691
	10 20 30 40 50 60 MASPNKKQHT NSDTWLIVGL GNPGDKYANT RHNVGRMVIG ELLDRQVPAA SLNTHKKTNT 70 80 90 100 110 120 DIAEVKIAGR KVVLAQPRTF MNVSGGPVQQ LAAFFKIPAE NIIVAYDDLE GDPGAVKLRQ 130 140 150 160 170 180 SGGDKGHNGL KSITKSLGTK DYWRLSCGIG RPPGRMDPAA YVLKPFPKSE AAEVAIMCAD 190 AADEVERTLG VGN

References

[1]

"Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora." Tauch A., Kaiser O., Hain T., Goesmann A., Weisshaar B., Albersmeier A., Bekel T., Bischoff N., Brune I., Chakraborty T., Kalinowski J., Meyer F., Rupp O., Schneiker S., Viehoever P., Puehler A. J. Bacteriol. 187:4671-4682(2005) [PubMed: 15968079] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR931997 Genomic DNA. Translation: CAI37668.1. Different initiation.
RefSeq	YP_251286.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3432994.
GenomeReviews	Gene locus jk1495 in contig CR931997_GR.
KEGG	cjk:jk1495.
NMPDR	fig|306537.3.peg.748.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q4JU39.
Enzyme and pathway databases
BioCyc	CJEI306537:JK1495-MON.
Family and domain databases
HAMAP	MF_00083. [Tree]
InterPro	IPR001328. Pept_tRNA_hydro. IPR018171. Pept_tRNA_hydro_CS. [Graphical view]
PANTHER	PTHR17224. Pept_tRNA_hydro. 1 hit.
Pfam	PF01195. Pept_tRNA_hydro. 1 hit. [Graphical view]
ProDom	PD005324. PeptRNAhydrolase. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00447. pth. 1 hit.
PROSITE	PS01195. PEPT_TRNA_HYDROL_1. False negative. PS01196. PEPT_TRNA_HYDROL_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PTH1_CORJK

Accession

Primary (citable) accession number: Q4JU39

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	December 12, 2006
Last modified:	June 16, 2009
This is version 28 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)