Q4JU38 (PTH2_CORJK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptidyl-tRNA hydrolase 2
Short name=PTH 2
EC=3.1.1.29

Gene names

Name:	pth2
Ordered Locus Names:	jk1496

Organism

Corynebacterium jeikeium (strain K411) [Complete proteome] [HAMAP]

Taxonomic identifier

306537 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	240 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis By similarity. HAMAP MF_00083
Catalytic activity	N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA. HAMAP MF_00083
Subunit structure	Monomer By similarity. HAMAP MF_00083
Subcellular location	Cytoplasm By similarity HAMAP MF_00083.
Sequence similarities	Belongs to the PTH family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	aminoacyl-tRNA hydrolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 240	240	Peptidyl-tRNA hydrolase 2 HAMAP MF_00083		PRO_0000264026

Sequences

	Sequence		Length	Mass (Da)
	Q4JU38 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: 5FACA1DD8B825B7C	FASTA	240	26,242
	10 20 30 40 50 60 MAVSFLQSLF SVFRKKSSPQ EPATTTAGGP AKRTKLTVGE LQEFAPEWIV IGLGNPGAKY 70 80 90 100 110 120 ADTRHNIGYW PIDRLVERYE AQWLPVEGQK AHAALITVEE TPVLLLRSTT YMNNSGEAVG 130 140 150 160 170 180 PLASALSLPA ERIIVCHDEL DIAAGQVRIK DKGGEGGHNG LRSMTAELGT QHYVRVRMGI 190 200 210 220 230 240 GRPPKGTSVI DFVLSPFEEA DIDAENGWME NTLRDSVDSV TLIVNNGTDI ARNDIHTRKH

References

[1]

"Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora." Tauch A., Kaiser O., Hain T., Goesmann A., Weisshaar B., Albersmeier A., Bekel T., Bischoff N., Brune I., Chakraborty T., Kalinowski J., Meyer F., Rupp O., Schneiker S., Viehoever P., Puehler A. J. Bacteriol. 187:4671-4682(2005) [PubMed: 15968079] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K411.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR931997 Genomic DNA. Translation: CAI37669.1.
RefSeq	YP_251287.1. NC_007164.1.
3D structure databases
ProteinModelPortal	Q4JU38.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4JU38.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3432995.
GenomeReviews	Gene locus jk1496 in contig CR931997_GR.
KEGG	cjk:jk1496.
NMPDR	fig|306537.3.peg.749.
PATRIC	21513942. VBICorJei31838_1516.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0193.
HOGENOM	HBG610927.
OMA	PEWIVIG.
ProtClustDB	PRK05426.
Enzyme and pathway databases
BioCyc	CJEI306537:JK1496-MONOMER.
Family and domain databases
HAMAP	MF_00083. Pept_tRNA_hydro_bact. [Tree]
InterPro	IPR001328. Pept_tRNA_hydro. IPR018171. Pept_tRNA_hydro_CS. [Graphical view]
Gene3D	G3DSA:3.40.50.1470. Pept_tRNA_hydro. 1 hit.
KO	K01056.
PANTHER	PTHR17224. Pept_tRNA_hydro. 1 hit.
Pfam	PF01195. Pept_tRNA_hydro. 1 hit. [Graphical view]
SUPFAM	SSF53178. Pept_tRNA_hydro. 1 hit.
TIGRFAMs	TIGR00447. Pth. 1 hit.
PROSITE	PS01195. PEPT_TRNA_HYDROL_1. False negative. PS01196. PEPT_TRNA_HYDROL_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PTH2_CORJK

Accession

Primary (citable) accession number: Q4JU38

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	August 2, 2005
Last modified:	January 25, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program