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Q4JU18

- SYM_CORJK

UniProt

Q4JU18 - SYM_CORJK

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Protein

Methionine--tRNA ligase

Gene

metG

Organism
Corynebacterium jeikeium (strain K411)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.UniRule annotation

Catalytic activityi

ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met).UniRule annotation

Cofactori

Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi144 – 1441ZincUniRule annotation
Metal bindingi147 – 1471ZincUniRule annotation
Metal bindingi157 – 1571ZincUniRule annotation
Metal bindingi160 – 1601ZincUniRule annotation
Binding sitei353 – 3531ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW
  3. methionine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. methionyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciCJEI306537:GJ8V-1564-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine--tRNA ligaseUniRule annotation (EC:6.1.1.10UniRule annotation)
Alternative name(s):
Methionyl-tRNA synthetaseUniRule annotation
Short name:
MetRSUniRule annotation
Gene namesi
Name:metGUniRule annotation
Ordered Locus Names:jk1516
OrganismiCorynebacterium jeikeium (strain K411)
Taxonomic identifieri306537 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000000545: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 612612Methionine--tRNA ligasePRO_0000331808Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi306537.jk1516.

Structurei

3D structure databases

ProteinModelPortaliQ4JU18.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi12 – 2211"HIGH" regionAdd
BLAST
Motifi350 – 3545"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0143.
HOGENOMiHOG000200402.
KOiK01874.
OMAiFKTETEI.
OrthoDBiEOG6CVV9B.

Family and domain databases

Gene3Di1.10.730.10. 2 hits.
2.20.28.20. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00098. Met_tRNA_synth_type1.
InterProiIPR023458. Met-tRNA_ligase_1.
IPR014758. Met-tRNA_synth.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR029038. MetRS_Zn.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PfamiPF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR01041. TRNASYNTHMET.
SUPFAMiSSF47323. SSF47323. 2 hits.
SSF57770. SSF57770. 1 hit.
TIGRFAMsiTIGR00398. metG. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4JU18-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKRVLTSVA WPYANGPRHI GHVAGFGVPS DVFARYQRMA GNEVLMVSGT
60 70 80 90 100
DEHGTPLLVQ AEKEGTTVQE LADRYNRIIV EDLAGLGLSY DLFTRTTTRN
110 120 130 140 150
HYAVVQELFT GLYNNGYMVT QTTRGAISPS TGRTLPDRYI EGTCPICGAK
160 170 180 190 200
DARGDQCDNC GNQLDPEDLI DPRSKINGET PEFIDTEHFM LDLPALAEAL
210 220 230 240 250
TTWLKGRTDW RPNVLKFSLN LLEDIRPRAM SRDIDWGVPI PVEGWQDNNA
260 270 280 290 300
KKLYVWFDAV VGYLSASIEW AWRIGDPDAW RKWWNDPEAL SYYFMGKDNI
310 320 330 340 350
TFHSQIWPAE LLGYGGQGSK GGEAGDLADP ALNLPTEVVS SEFLTMSGSK
360 370 380 390 400
FSSSKGVVIY VRDFLKEFGP DALRYFIATA GPETTDTDFT WDEFVRRINS
410 420 430 440 450
ELANEWGNLV NRTVSMAYKN FGEVPTPGPL TAEDEALLAE SAKAFDVVGD
460 470 480 490 500
NINLSRFKAG ITEAMRIAGR ANQYIAAMEP WKLAKDENQR ERLATVLYTA
510 520 530 540 550
LQVVSDVNTL LTPYLPFSAQ KIFETLGGEG IWAAQPEVVE VTDESPREPV
560 570 580 590 600
GVGLPEEGRT YPVIMGDYTK QKVTWARQEI QPGTQLSKPK PLFPKLDPEL
610
AETGPEWAPV QK
Length:612
Mass (Da):68,132
Last modified:August 2, 2005 - v1
Checksum:iE01E6207EFE8ED13
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR931997 Genomic DNA. Translation: CAI37689.1.
RefSeqiYP_251307.1. NC_007164.1.

Genome annotation databases

EnsemblBacteriaiCAI37689; CAI37689; jk1516.
GeneIDi3433307.
KEGGicjk:jk1516.
PATRICi21513982. VBICorJei31838_1536.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR931997 Genomic DNA. Translation: CAI37689.1 .
RefSeqi YP_251307.1. NC_007164.1.

3D structure databases

ProteinModelPortali Q4JU18.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 306537.jk1516.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAI37689 ; CAI37689 ; jk1516 .
GeneIDi 3433307.
KEGGi cjk:jk1516.
PATRICi 21513982. VBICorJei31838_1536.

Phylogenomic databases

eggNOGi COG0143.
HOGENOMi HOG000200402.
KOi K01874.
OMAi FKTETEI.
OrthoDBi EOG6CVV9B.

Enzyme and pathway databases

BioCyci CJEI306537:GJ8V-1564-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 2 hits.
2.20.28.20. 1 hit.
3.40.50.620. 2 hits.
HAMAPi MF_00098. Met_tRNA_synth_type1.
InterProi IPR023458. Met-tRNA_ligase_1.
IPR014758. Met-tRNA_synth.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR029038. MetRS_Zn.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view ]
Pfami PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR01041. TRNASYNTHMET.
SUPFAMi SSF47323. SSF47323. 2 hits.
SSF57770. SSF57770. 1 hit.
TIGRFAMsi TIGR00398. metG. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora."
    Tauch A., Kaiser O., Hain T., Goesmann A., Weisshaar B., Albersmeier A., Bekel T., Bischoff N., Brune I., Chakraborty T., Kalinowski J., Meyer F., Rupp O., Schneiker S., Viehoever P., Puehler A.
    J. Bacteriol. 187:4671-4682(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K411.

Entry informationi

Entry nameiSYM_CORJK
AccessioniPrimary (citable) accession number: Q4JU18
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: August 2, 2005
Last modified: October 29, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3