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Q4JU18

- SYM_CORJK

UniProt

Q4JU18 - SYM_CORJK

Protein

Methionine--tRNA ligase

Gene

metG

Organism
Corynebacterium jeikeium (strain K411)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (02 Aug 2005)
      Previous versions | rss
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    Functioni

    Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.UniRule annotation

    Catalytic activityi

    ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met).UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi144 – 1441ZincUniRule annotation
    Metal bindingi147 – 1471ZincUniRule annotation
    Metal bindingi157 – 1571ZincUniRule annotation
    Metal bindingi160 – 1601ZincUniRule annotation
    Binding sitei353 – 3531ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW
    3. methionine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. methionyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    BioCyciCJEI306537:GJ8V-1564-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Methionine--tRNA ligaseUniRule annotation (EC:6.1.1.10UniRule annotation)
    Alternative name(s):
    Methionyl-tRNA synthetaseUniRule annotation
    Short name:
    MetRSUniRule annotation
    Gene namesi
    Name:metGUniRule annotation
    Ordered Locus Names:jk1516
    OrganismiCorynebacterium jeikeium (strain K411)
    Taxonomic identifieri306537 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
    ProteomesiUP000000545: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 612612Methionine--tRNA ligasePRO_0000331808Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi306537.jk1516.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4JU18.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi12 – 2211"HIGH" regionAdd
    BLAST
    Motifi350 – 3545"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0143.
    HOGENOMiHOG000200402.
    KOiK01874.
    OMAiFKTETEI.
    OrthoDBiEOG6CVV9B.

    Family and domain databases

    Gene3Di1.10.730.10. 2 hits.
    2.20.28.20. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPiMF_00098. Met_tRNA_synth_type1.
    InterProiIPR023458. Met-tRNA_ligase_1.
    IPR014758. Met-tRNA_synth.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR029038. MetRS_Zn.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    [Graphical view]
    PfamiPF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR01041. TRNASYNTHMET.
    SUPFAMiSSF47323. SSF47323. 2 hits.
    SSF57770. SSF57770. 1 hit.
    TIGRFAMsiTIGR00398. metG. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q4JU18-1 [UniParc]FASTAAdd to Basket

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    MSKRVLTSVA WPYANGPRHI GHVAGFGVPS DVFARYQRMA GNEVLMVSGT    50
    DEHGTPLLVQ AEKEGTTVQE LADRYNRIIV EDLAGLGLSY DLFTRTTTRN 100
    HYAVVQELFT GLYNNGYMVT QTTRGAISPS TGRTLPDRYI EGTCPICGAK 150
    DARGDQCDNC GNQLDPEDLI DPRSKINGET PEFIDTEHFM LDLPALAEAL 200
    TTWLKGRTDW RPNVLKFSLN LLEDIRPRAM SRDIDWGVPI PVEGWQDNNA 250
    KKLYVWFDAV VGYLSASIEW AWRIGDPDAW RKWWNDPEAL SYYFMGKDNI 300
    TFHSQIWPAE LLGYGGQGSK GGEAGDLADP ALNLPTEVVS SEFLTMSGSK 350
    FSSSKGVVIY VRDFLKEFGP DALRYFIATA GPETTDTDFT WDEFVRRINS 400
    ELANEWGNLV NRTVSMAYKN FGEVPTPGPL TAEDEALLAE SAKAFDVVGD 450
    NINLSRFKAG ITEAMRIAGR ANQYIAAMEP WKLAKDENQR ERLATVLYTA 500
    LQVVSDVNTL LTPYLPFSAQ KIFETLGGEG IWAAQPEVVE VTDESPREPV 550
    GVGLPEEGRT YPVIMGDYTK QKVTWARQEI QPGTQLSKPK PLFPKLDPEL 600
    AETGPEWAPV QK 612
    Length:612
    Mass (Da):68,132
    Last modified:August 2, 2005 - v1
    Checksum:iE01E6207EFE8ED13
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR931997 Genomic DNA. Translation: CAI37689.1.
    RefSeqiYP_251307.1. NC_007164.1.

    Genome annotation databases

    EnsemblBacteriaiCAI37689; CAI37689; jk1516.
    GeneIDi3433307.
    KEGGicjk:jk1516.
    PATRICi21513982. VBICorJei31838_1536.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR931997 Genomic DNA. Translation: CAI37689.1 .
    RefSeqi YP_251307.1. NC_007164.1.

    3D structure databases

    ProteinModelPortali Q4JU18.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 306537.jk1516.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAI37689 ; CAI37689 ; jk1516 .
    GeneIDi 3433307.
    KEGGi cjk:jk1516.
    PATRICi 21513982. VBICorJei31838_1536.

    Phylogenomic databases

    eggNOGi COG0143.
    HOGENOMi HOG000200402.
    KOi K01874.
    OMAi FKTETEI.
    OrthoDBi EOG6CVV9B.

    Enzyme and pathway databases

    BioCyci CJEI306537:GJ8V-1564-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 2 hits.
    2.20.28.20. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPi MF_00098. Met_tRNA_synth_type1.
    InterProi IPR023458. Met-tRNA_ligase_1.
    IPR014758. Met-tRNA_synth.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR029038. MetRS_Zn.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    [Graphical view ]
    Pfami PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR01041. TRNASYNTHMET.
    SUPFAMi SSF47323. SSF47323. 2 hits.
    SSF57770. SSF57770. 1 hit.
    TIGRFAMsi TIGR00398. metG. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora."
      Tauch A., Kaiser O., Hain T., Goesmann A., Weisshaar B., Albersmeier A., Bekel T., Bischoff N., Brune I., Chakraborty T., Kalinowski J., Meyer F., Rupp O., Schneiker S., Viehoever P., Puehler A.
      J. Bacteriol. 187:4671-4682(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K411.

    Entry informationi

    Entry nameiSYM_CORJK
    AccessioniPrimary (citable) accession number: Q4JU18
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: August 2, 2005
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3