Reviewed, UniProtKB/Swiss-Prot Q4JTH1 (DNAE2_CORJK)

Names and origin

Protein names

Recommended name:
    Error-prone DNA polymerase
    EC=2.7.7.7

Gene names

Name:	dnaE2
Ordered Locus Names:	jk1709

Organism

Corynebacterium jeikeium (strain K411) [Complete proteome] [HAMAP]

Taxonomic identifier

306537 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	1153 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase By similarity.
Catalytic activity	Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). HAMAP MF_01902
Subcellular location	CytoplasmProbable.
Sequence similarities	Belongs to the DNA polymerase type-C family. DnaE2 subfamily.

Ontologies

Keywords
Biological process	DNA damage DNA repair DNA replication
Cellular component	Cytoplasm
Molecular function	DNA-directed DNA polymerase Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA replication Inferred from electronic annotation. Source: InterPro error-prone DNA repair Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	3'-5' exonuclease activity Inferred from electronic annotation. Source: InterPro DNA binding Inferred from electronic annotation. Source: InterPro DNA-directed DNA polymerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1153	1153	Error-prone DNA polymerase HAMAP MF_01902		PRO_0000103379

Sequences

	Sequence		Length	Mass (Da)
	Q4JTH1-1 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: ABA8D590EEB42173	FASTA	1,153	124,693
	10 20 30 40 50 60 MFYSCCVSIE PRDPASEPTP TPRRPLRKSQ PRSFSQAQPL SWAQLESVLS GRGAGLRNLR 70 80 90 100 110 120 AVGVGEGQRR TTSLDPAEAE GTGAEGASQK GITTPFAELH ASSAYNFLRG ASQPEQMVEA 130 140 150 160 170 180 ARELGLSALA CVDRDGFYGA ARFATAVAES GADLATVFGA ELSLDVPLTV LCKGREGYTR 190 200 210 220 230 240 LSRVIADARM ADPDKDSVRY PSLPQLAEAA GGHWLVLLDW RRTDAQLVDF FGADNVVVEL 250 260 270 280 290 300 QHTMNPADAD RNERLHALAV RHGLREIVSS APTCATPKHS RLAGAKAALR ERKDMAAAEP 310 320 330 340 350 360 TTHPVGGSWL RSGEEMLQLA GDCEWLARAV ETSVQVAEEC AFTLDLVAPN LPHFPVPEGY 370 380 390 400 410 420 TEMTWLRAIT ERGGAQRYGP RGSSAAANQA WATIDRELET IEQLGFPGYF LIVHDIVSFC 430 440 450 460 470 480 HENNIFCQGR GSAANSAVCF ALGITTVDAV ASGLLFERFL SPERDGPPDI DLDIESGRRE 490 500 510 520 530 540 EAIQYVYSRY GRENAAQVAN VITYRRRGAT RDAGRALGYA PGQIDAWTRH PEQTPDVVQN 550 560 570 580 590 600 LAEQMLDHPR HLGIHSGGMV ICDRPIAQVV PTEWARMEGR SVVQWDKDDC AAVGLVKFDL 610 620 630 640 650 660 LGLGMLEALH HAVDQVRAHR GREVELWRLD PTESEVYAML SRADAVGVFQ VESRAQMSTL 670 680 690 700 710 720 PRLKPRTFYD LVVEVALIRP GPIQGGSVHP YIRRRNGLEP VTFDHPCLEP ALTKTLGIPL 730 740 750 760 770 780 FQEQLMQMAV DAAGFSGAEA DTLRRAMGSK RSPQKMERLK KRFYQGLEAK NGIRGVVADR 790 800 810 820 830 840 LWDKIVAFAS YGFPESHSQS FASLVYYSAW FKYHYPAEFC VALLRAQPMG FYSPQSLLAD 850 860 870 880 890 900 ARRHGVEVLP VDVNDSDVQV DAVASLATPP RTNRPTGVHG LGRGTGEPVG QIRLGLSGAG 910 920 930 940 950 960 GVKGISAEVA ERIVEARERI GRFTSVEDLS REAGLTVAHV EKLARAGALG SLGLTRRQAV 970 980 990 1000 1010 1020 WAAGVAATER PGMLPGTSGV HAPALPGMSA FEMVASELAT TGVTTAEHPV QLLREYLDEW 1030 1040 1050 1060 1070 1080 HLRPAPRGVH PGDAAPRGGA AVVTADSLLR VPDGTRVRVA GVVTHRQRPA TAGGVVFFGL 1090 1100 1110 1120 1130 1140 EDETGLANIV VSQGLWARQR AVALNAKILV VRGIVHNAEG AATVTADLLE QVETQLRPAG 1150 EIAGAHAGSR DFR

References

[1]

"Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora." Tauch A., Kaiser O., Hain T., Goesmann A., Weisshaar B., Albersmeier A., Bekel T., Bischoff N., Brune I., Chakraborty T., Kalinowski J., Meyer F., Rupp O., Schneiker S., Viehoever P., Puehler A. J. Bacteriol. 187:4671-4682(2005) [PubMed: 15968079] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR931997 Genomic DNA. Translation: CAI37886.1.
RefSeq	YP_251504.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3433710.
GenomeReviews	Gene locus jk1709 in contig CR931997_GR.
KEGG	cjk:jk1709.
NMPDR	fig|306537.3.peg.1557.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q4JTH1.
Enzyme and pathway databases
BioCyc	CJEI306537:JK1709-MON.
Family and domain databases
HAMAP	MF_01902. [Tree]
InterPro	IPR011708. DNA_pol3_alpha. IPR004365. NA_bd_OB_tRNA-helicase. IPR004013. PHP_C. IPR003141. PHP_N. IPR004805. PolC_alpha. [Graphical view]
Pfam	PF07733. DNA_pol3_alpha. 1 hit. PF02811. PHP. 1 hit. PF01336. tRNA_anti. 1 hit. [Graphical view]
SMART	SM00481. POLIIIAc. 1 hit. [Graphical view]
TIGRFAMs	TIGR00594. polc. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DNAE2_CORJK

Accession

Primary (citable) accession number: Q4JTH1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 25, 2005
Last sequence update:	August 2, 2005
Last modified:	November 25, 2008
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)