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Protein

DNA-directed RNA polymerase subunit beta

Gene

rpoB

Organism
Corynebacterium jeikeium (strain K411)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.UniRule annotation

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Transcription

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit betaUniRule annotation (EC:2.7.7.6UniRule annotation)
Short name:
RNAP subunit betaUniRule annotation
Alternative name(s):
RNA polymerase subunit betaUniRule annotation
Transcriptase subunit betaUniRule annotation
Gene namesi
Name:rpoBUniRule annotation
Ordered Locus Names:jk1846
OrganismiCorynebacterium jeikeium (strain K411)
Taxonomic identifieri306537 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000000545 Componenti: Chromosome

Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002240471 – 1164DNA-directed RNA polymerase subunit betaAdd BLAST1164

Proteomic databases

PRIDEiQ4JT32.

Interactioni

Subunit structurei

The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.UniRule annotation

Protein-protein interaction databases

STRINGi306537.jk1846.

Structurei

3D structure databases

ProteinModelPortaliQ4JT32.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNA polymerase beta chain family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108IIJ. Bacteria.
COG0085. LUCA.
HOGENOMiHOG000218611.
KOiK03043.
OMAiWWMFAVE.
OrthoDBiPOG091H01MI.

Family and domain databases

CDDicd00653. RNA_pol_B_RPB2. 1 hit.
Gene3Di2.30.150.10. 1 hit.
2.40.270.10. 2 hits.
2.40.50.150. 1 hit.
3.90.1110.10. 1 hit.
HAMAPiMF_01321. RNApol_bact_RpoB. 1 hit.
InterProiIPR019462. DNA-dir_RNA_pol_bsu_external_1.
IPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR010243. RNA_pol_bsu_bac.
IPR007121. RNA_pol_bsu_CS.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
[Graphical view]
PANTHERiPTHR20856. PTHR20856. 3 hits.
PfamiPF04563. RNA_pol_Rpb2_1. 1 hit.
PF04561. RNA_pol_Rpb2_2. 1 hit.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF10385. RNA_pol_Rpb2_45. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02013. rpoB. 1 hit.
PROSITEiPS01166. RNA_POL_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4JT32-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVSRQTSSV AGIPGAPQRH SFAKIDAPIE VPGLLDLQRE SFAWLVGTPE
60 70 80 90 100
WRARAQAEAG EDVRIMSGLE EILEELSPIE DYSENMSLTL SEPRFDDVKS
110 120 130 140 150
TIDEAKDKDI NYAAPLYVTA EFTNSMSGEI KSQTVFIGDF PMMTDKGTFI
160 170 180 190 200
INGTERVVVS QLVRSPGVYF DASIDASTER PLHSVKVIPS RGAWLEFDVD
210 220 230 240 250
KRDTVGVRID RKRRQPVTVL LKALGLTTQE ITDRFGFSEL MMSTLEKDGV
260 270 280 290 300
DNTDEALLEI YRKQRPGESP TRDSAQALLE NSFFKAKRYD LAKVGRYKVN
310 320 330 340 350
RKLGLGGDTD GVMTLTEEDI LTTIEYLVRL HAGEKSMTSP DGTEIPIDTD
360 370 380 390 400
DIDHFGNRRL RTVGELIQNQ VRVGLSRMER VVRERMTTQD AESITPTSLI
410 420 430 440 450
NVRPVSAAIR EFFGTSQLSQ FLDQNNSLSG LTHKRRLSAL GPGGLSRERA
460 470 480 490 500
GLEVRDVHPS HYGRMCPIET PEGPNIGLIG SLSSYARVNP FGFIETPYRK
510 520 530 540 550
VVDGQITDEV YYFTADEEDR HVIAQANTPF DENHRFTEER IEVRLRGGDV
560 570 580 590 600
EVVPYTEVDY MDVSPRQMVS VATAMIPFLE HDDANRALMG ANMQRQAVPL
610 620 630 640 650
LRSEAPFVGT GMELRAAYDA GDMIIAPKAG VVEYVSADYI TVMDDEGVRD
660 670 680 690 700
TFMLRKFERT NQGTCYNQTP LVDEGDRVEA GQVLADGPGT DNGEMALGKN
710 720 730 740 750
LLVAFMPWEG HNYEDAIILN QRMVEEDVLT SIHIEEYEID ARDTKLGPEE
760 770 780 790 800
ITRDIPNVGE DVLADLDERG IVRIGADVRD GDILVGKVTP KGETELTPEE
810 820 830 840 850
RLLRAIFGEK AREVRDTSMK VPHGETGKVI GVRVFSREDD DDLAAGVNEM
860 870 880 890 900
VRVYVAQKRK IQDGDKLAGR HGNKGVVGKI LPQEDMPFLP DGTPIDIILN
910 920 930 940 950
THGVPRRMNI GQVLEVHLGW LAKAGWKVDP DSQDPKIQKM LETLPEELYE
960 970 980 990 1000
IPADSLTATP VFDGASNAEL SGLLRSSLPN RDGERQVDDF GKSNLIDGRS
1010 1020 1030 1040 1050
GEPFPYPVAV GYMYMLKLHH LVDEKIHARS TGPYSMITQQ PLGGKAQFGG
1060 1070 1080 1090 1100
QRFGEMEVWA MQAYGAAYTL QELLTIKSDD VVGRVKVYEA IVKGENIPDP
1110 1120 1130 1140 1150
GIPESFKVLL KELQSLCLNV EVLAADGTPM ELSSDDDDEL ENANAALGIN
1160
LSRDERPDAD MDVS
Length:1,164
Mass (Da):129,104
Last modified:August 2, 2005 - v1
Checksum:i943B2E18A2C9E6DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR931997 Genomic DNA. Translation: CAI38025.1.

Genome annotation databases

EnsemblBacteriaiCAI38025; CAI38025; jk1846.
KEGGicjk:jk1846.
PATRICi21514652. VBICorJei31838_1872.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR931997 Genomic DNA. Translation: CAI38025.1.

3D structure databases

ProteinModelPortaliQ4JT32.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi306537.jk1846.

Proteomic databases

PRIDEiQ4JT32.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAI38025; CAI38025; jk1846.
KEGGicjk:jk1846.
PATRICi21514652. VBICorJei31838_1872.

Phylogenomic databases

eggNOGiENOG4108IIJ. Bacteria.
COG0085. LUCA.
HOGENOMiHOG000218611.
KOiK03043.
OMAiWWMFAVE.
OrthoDBiPOG091H01MI.

Family and domain databases

CDDicd00653. RNA_pol_B_RPB2. 1 hit.
Gene3Di2.30.150.10. 1 hit.
2.40.270.10. 2 hits.
2.40.50.150. 1 hit.
3.90.1110.10. 1 hit.
HAMAPiMF_01321. RNApol_bact_RpoB. 1 hit.
InterProiIPR019462. DNA-dir_RNA_pol_bsu_external_1.
IPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR010243. RNA_pol_bsu_bac.
IPR007121. RNA_pol_bsu_CS.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
[Graphical view]
PANTHERiPTHR20856. PTHR20856. 3 hits.
PfamiPF04563. RNA_pol_Rpb2_1. 1 hit.
PF04561. RNA_pol_Rpb2_2. 1 hit.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF10385. RNA_pol_Rpb2_45. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02013. rpoB. 1 hit.
PROSITEiPS01166. RNA_POL_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRPOB_CORJK
AccessioniPrimary (citable) accession number: Q4JT32
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: August 2, 2005
Last modified: November 2, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.