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Q4JT32 (RPOB_CORJK) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
DNA-directed RNA polymerase subunit beta
Short name=RNAP subunit beta
EC=2.7.7.6
Alternative name(s):
RNA polymerase subunit beta
Transcriptase subunit beta
Gene names
Name:rpoB
Ordered Locus Names:jk1846
OrganismCorynebacterium jeikeium (strain K411) [Complete proteome] [HAMAP]
Taxonomic identifier306537 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length1164 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. HAMAP MF_01321

Catalytic activity

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). HAMAP MF_01321

Subunit structure

The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription By similarity.

Sequence similarities

Belongs to the RNA polymerase beta chain family.

Ontologies

Keywords
   Biological processTranscription
   Cellular componentDNA-directed RNA polymerase
   Molecular functionNucleotidyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular functionDNA binding

Inferred from electronic annotation. Source: InterPro

DNA-directed RNA polymerase activity

Inferred from electronic annotation. Source: UniProtKB-KW

ribonucleoside binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11641164DNA-directed RNA polymerase subunit beta HAMAP MF_01321
PRO_0000224047

Sequences

Sequence LengthMass (Da)Tools
Q4JT32 [UniParc].

Last modified August 2, 2005. Version 1.
Checksum: 943B2E18A2C9E6DD

FASTA1,164129,104
        10         20         30         40         50         60 
MAVSRQTSSV AGIPGAPQRH SFAKIDAPIE VPGLLDLQRE SFAWLVGTPE WRARAQAEAG 

        70         80         90        100        110        120 
EDVRIMSGLE EILEELSPIE DYSENMSLTL SEPRFDDVKS TIDEAKDKDI NYAAPLYVTA 

       130        140        150        160        170        180 
EFTNSMSGEI KSQTVFIGDF PMMTDKGTFI INGTERVVVS QLVRSPGVYF DASIDASTER 

       190        200        210        220        230        240 
PLHSVKVIPS RGAWLEFDVD KRDTVGVRID RKRRQPVTVL LKALGLTTQE ITDRFGFSEL 

       250        260        270        280        290        300 
MMSTLEKDGV DNTDEALLEI YRKQRPGESP TRDSAQALLE NSFFKAKRYD LAKVGRYKVN 

       310        320        330        340        350        360 
RKLGLGGDTD GVMTLTEEDI LTTIEYLVRL HAGEKSMTSP DGTEIPIDTD DIDHFGNRRL 

       370        380        390        400        410        420 
RTVGELIQNQ VRVGLSRMER VVRERMTTQD AESITPTSLI NVRPVSAAIR EFFGTSQLSQ 

       430        440        450        460        470        480 
FLDQNNSLSG LTHKRRLSAL GPGGLSRERA GLEVRDVHPS HYGRMCPIET PEGPNIGLIG 

       490        500        510        520        530        540 
SLSSYARVNP FGFIETPYRK VVDGQITDEV YYFTADEEDR HVIAQANTPF DENHRFTEER 

       550        560        570        580        590        600 
IEVRLRGGDV EVVPYTEVDY MDVSPRQMVS VATAMIPFLE HDDANRALMG ANMQRQAVPL 

       610        620        630        640        650        660 
LRSEAPFVGT GMELRAAYDA GDMIIAPKAG VVEYVSADYI TVMDDEGVRD TFMLRKFERT 

       670        680        690        700        710        720 
NQGTCYNQTP LVDEGDRVEA GQVLADGPGT DNGEMALGKN LLVAFMPWEG HNYEDAIILN 

       730        740        750        760        770        780 
QRMVEEDVLT SIHIEEYEID ARDTKLGPEE ITRDIPNVGE DVLADLDERG IVRIGADVRD 

       790        800        810        820        830        840 
GDILVGKVTP KGETELTPEE RLLRAIFGEK AREVRDTSMK VPHGETGKVI GVRVFSREDD 

       850        860        870        880        890        900 
DDLAAGVNEM VRVYVAQKRK IQDGDKLAGR HGNKGVVGKI LPQEDMPFLP DGTPIDIILN 

       910        920        930        940        950        960 
THGVPRRMNI GQVLEVHLGW LAKAGWKVDP DSQDPKIQKM LETLPEELYE IPADSLTATP 

       970        980        990       1000       1010       1020 
VFDGASNAEL SGLLRSSLPN RDGERQVDDF GKSNLIDGRS GEPFPYPVAV GYMYMLKLHH 

      1030       1040       1050       1060       1070       1080 
LVDEKIHARS TGPYSMITQQ PLGGKAQFGG QRFGEMEVWA MQAYGAAYTL QELLTIKSDD 

      1090       1100       1110       1120       1130       1140 
VVGRVKVYEA IVKGENIPDP GIPESFKVLL KELQSLCLNV EVLAADGTPM ELSSDDDDEL 

      1150       1160 
ENANAALGIN LSRDERPDAD MDVS

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References

[1]"Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora."
Tauch A., Kaiser O., Hain T., Goesmann A., Weisshaar B., Albersmeier A., Bekel T., Bischoff N., Brune I., Chakraborty T., Kalinowski J., Meyer F., Rupp O., Schneiker S., Viehoever P., Puehler A.
J. Bacteriol. 187:4671-4682(2005) [PubMed: 15968079] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K411.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR931997 Genomic DNA. Translation: CAI38025.1.
RefSeqYP_251643.1. NC_007164.1.

3D structure databases

ProteinModelPortalQ4JT32.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ4JT32.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3433928.
GenomeReviewsGene locus jk1846 in contig CR931997_GR.
KEGGcjk:jk1846.
NMPDRfig|306537.3.peg.65.
PATRIC21514652. VBICorJei31838_1872.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0085.
HOGENOMHBG285547.
OMAQRDLTYA.
ProtClustDBPRK00405.

Enzyme and pathway databases

BioCycCJEI306537:JK1846-MONOMER.

Family and domain databases

HAMAPMF_01321. RNApol_bact_RpoB.
[Tree]
InterProIPR010243. DNA-dir_RNA_pol_bsu_bac-type.
IPR019462. DNA-dir_RNA_pol_bsu_external_1.
IPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR007121. RNA_pol_bsu_CS.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
[Graphical view]
Gene3DG3DSA:2.30.150.10. G3DSA:2.30.150.10. 1 hit.
G3DSA:2.40.270.10. G3DSA:2.40.270.10. 2 hits.
G3DSA:2.40.50.150. Ribosomal_L2. 1 hit.
KOK03043.
PANTHERPTHR20856:SF3. PTHR20856:SF3. 1 hit.
PTHR20856. RNA_pol_I_sub2. 1 hit.
PfamPF04563. RNA_pol_Rpb2_1. 1 hit.
PF04561. RNA_pol_Rpb2_2. 1 hit.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF10385. RNA_pol_Rpb2_45. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view]
TIGRFAMsTIGR02013. RpoB. 1 hit.
PROSITEPS01166. RNA_POL_BETA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRPOB_CORJK
AccessionPrimary (citable) accession number: Q4JT32
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: August 2, 2005
Last modified: January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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