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Q4JSF0

- SYL_CORJK

UniProt

Q4JSF0 - SYL_CORJK

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Corynebacterium jeikeium (strain K411)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (02 Aug 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei748 – 7481ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCJEI306537:GJ8V-2136-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:jk2075
    OrganismiCorynebacterium jeikeium (strain K411)
    Taxonomic identifieri306537 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
    ProteomesiUP000000545: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 976976Leucine--tRNA ligasePRO_0000334746Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi306537.jk2075.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4JSF0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi63 – 7412"HIGH" regionAdd
    BLAST
    Motifi745 – 7495"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiKGNPLES.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 4 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF13603. tRNA-synt_1_2. 2 hits.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q4JSF0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTNGSTEDNS YRYTPGLAAK IEAKWQKHWA DKGTFNAPNP TGDLAEPGAE    50
    LPEDRKFIQD MFPYPSGVGL HVGHPLGYIG TDVFARFHRM KGANVLHTLG 100
    YDAFGLPAEQ YAVQTGTHPR TTTMANIANM ERQLGRLGLG HDKRRSFATT 150
    DTDYYRWTQW IFLQIYNSWF DPEAKNANGT LGKARPIKEL EEKLAAERAD 200
    WADLSAAEKQ EILDSYRLVY RSNSTVNWCP GLGTVLANEE VTAEGRSERG 250
    NFPVFRKNLQ QWMMRITAYS DRLIDDLEYL DWPEKVKSMQ RNWIGRSRGA 300
    EVTFDCLGND IDVFTTRPDT LFGATYMVLA PEHELVDTLV AQSGNSSSGS 350
    DAYTDVDPRW TYGQANPAAA VEAYRAAIAA KSDLERQENK EKTGVFLGVY 400
    ATNPVNGAQV PVFIADYVLT GYGTGAIMAV PAHDSRDFEF ATEFGLPIVP 450
    VLAPEGAEAG AGEQGGAELT EAFTEDGPHI NSNNSDGLEL NGLGKAEAID 500
    KAIEWLESKG VGSGKIQYKL RDWLFARQRY WGEPFPIVYD EDGTAHGLPE 550
    DMLPVELPEV EDYKPVSFDP DDKDSAPQPP LAKAKDWVEV TLDLGDGEKT 600
    YYRDTNVMPQ WAGSSWYQLR YIDPNNDNAL VDIENERYWV GPREGRPSGG 650
    VDLYVGGVEH AVLHLLYARF WHKVLFDLGV VSSFEPYYRL YNQGYIQAYA 700
    YTDSRGVYVP AEEVTERDGK FFWVRKADDA EGVTKEEEVF QEYGKMGKSL 750
    KNAVSPDEIC DDYGADTLRV YEMAMGPLDT SRPWATKDVV GAQRFLQRAW 800
    RLAVDENTGK GSVSDDALTD EDLKALHRTI AGVHENYAEL RDNTAVAKLI 850
    EYVNYLTKTY SAGQAPRAAV EPLVQMLSPV APHIAEEMWE ILGHSEGITY 900
    ESFPEWDEKW LVDDTIELPV QVMGKLRGRI NVAADASRED IEAAALEEPN 950
    VASHIEGKTV AKIIVVPGKM VNIVAK 976
    Length:976
    Mass (Da):108,844
    Last modified:August 2, 2005 - v1
    Checksum:iF70D707285B5C31E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR931997 Genomic DNA. Translation: CAI38257.1.
    RefSeqiYP_251875.1. NC_007164.1.

    Genome annotation databases

    EnsemblBacteriaiCAI38257; CAI38257; jk2075.
    GeneIDi3433565.
    KEGGicjk:jk2075.
    PATRICi21515142. VBICorJei31838_2105.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR931997 Genomic DNA. Translation: CAI38257.1 .
    RefSeqi YP_251875.1. NC_007164.1.

    3D structure databases

    ProteinModelPortali Q4JSF0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 306537.jk2075.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAI38257 ; CAI38257 ; jk2075 .
    GeneIDi 3433565.
    KEGGi cjk:jk2075.
    PATRICi 21515142. VBICorJei31838_2105.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi KGNPLES.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci CJEI306537:GJ8V-2136-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 4 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF13603. tRNA-synt_1_2. 2 hits.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora."
      Tauch A., Kaiser O., Hain T., Goesmann A., Weisshaar B., Albersmeier A., Bekel T., Bischoff N., Brune I., Chakraborty T., Kalinowski J., Meyer F., Rupp O., Schneiker S., Viehoever P., Puehler A.
      J. Bacteriol. 187:4671-4682(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K411.

    Entry informationi

    Entry nameiSYL_CORJK
    AccessioniPrimary (citable) accession number: Q4JSF0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: August 2, 2005
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3