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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Corynebacterium jeikeium (strain K411)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei748 – 7481ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCJEI306537:GJ8V-2136-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:jk2075
OrganismiCorynebacterium jeikeium (strain K411)
Taxonomic identifieri306537 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
ProteomesiUP000000545 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 976976Leucine--tRNA ligasePRO_0000334746Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi306537.jk2075.

Structurei

3D structure databases

ProteinModelPortaliQ4JSF0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi63 – 7412"HIGH" regionAdd
BLAST
Motifi745 – 7495"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiREKNDWE.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 2 hits.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4JSF0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNGSTEDNS YRYTPGLAAK IEAKWQKHWA DKGTFNAPNP TGDLAEPGAE
60 70 80 90 100
LPEDRKFIQD MFPYPSGVGL HVGHPLGYIG TDVFARFHRM KGANVLHTLG
110 120 130 140 150
YDAFGLPAEQ YAVQTGTHPR TTTMANIANM ERQLGRLGLG HDKRRSFATT
160 170 180 190 200
DTDYYRWTQW IFLQIYNSWF DPEAKNANGT LGKARPIKEL EEKLAAERAD
210 220 230 240 250
WADLSAAEKQ EILDSYRLVY RSNSTVNWCP GLGTVLANEE VTAEGRSERG
260 270 280 290 300
NFPVFRKNLQ QWMMRITAYS DRLIDDLEYL DWPEKVKSMQ RNWIGRSRGA
310 320 330 340 350
EVTFDCLGND IDVFTTRPDT LFGATYMVLA PEHELVDTLV AQSGNSSSGS
360 370 380 390 400
DAYTDVDPRW TYGQANPAAA VEAYRAAIAA KSDLERQENK EKTGVFLGVY
410 420 430 440 450
ATNPVNGAQV PVFIADYVLT GYGTGAIMAV PAHDSRDFEF ATEFGLPIVP
460 470 480 490 500
VLAPEGAEAG AGEQGGAELT EAFTEDGPHI NSNNSDGLEL NGLGKAEAID
510 520 530 540 550
KAIEWLESKG VGSGKIQYKL RDWLFARQRY WGEPFPIVYD EDGTAHGLPE
560 570 580 590 600
DMLPVELPEV EDYKPVSFDP DDKDSAPQPP LAKAKDWVEV TLDLGDGEKT
610 620 630 640 650
YYRDTNVMPQ WAGSSWYQLR YIDPNNDNAL VDIENERYWV GPREGRPSGG
660 670 680 690 700
VDLYVGGVEH AVLHLLYARF WHKVLFDLGV VSSFEPYYRL YNQGYIQAYA
710 720 730 740 750
YTDSRGVYVP AEEVTERDGK FFWVRKADDA EGVTKEEEVF QEYGKMGKSL
760 770 780 790 800
KNAVSPDEIC DDYGADTLRV YEMAMGPLDT SRPWATKDVV GAQRFLQRAW
810 820 830 840 850
RLAVDENTGK GSVSDDALTD EDLKALHRTI AGVHENYAEL RDNTAVAKLI
860 870 880 890 900
EYVNYLTKTY SAGQAPRAAV EPLVQMLSPV APHIAEEMWE ILGHSEGITY
910 920 930 940 950
ESFPEWDEKW LVDDTIELPV QVMGKLRGRI NVAADASRED IEAAALEEPN
960 970
VASHIEGKTV AKIIVVPGKM VNIVAK
Length:976
Mass (Da):108,844
Last modified:August 2, 2005 - v1
Checksum:iF70D707285B5C31E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR931997 Genomic DNA. Translation: CAI38257.1.
RefSeqiWP_005292496.1. NC_007164.1.
YP_251875.1. NC_007164.1.

Genome annotation databases

EnsemblBacteriaiCAI38257; CAI38257; jk2075.
GeneIDi3433565.
KEGGicjk:jk2075.
PATRICi21515142. VBICorJei31838_2105.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR931997 Genomic DNA. Translation: CAI38257.1.
RefSeqiWP_005292496.1. NC_007164.1.
YP_251875.1. NC_007164.1.

3D structure databases

ProteinModelPortaliQ4JSF0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi306537.jk2075.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAI38257; CAI38257; jk2075.
GeneIDi3433565.
KEGGicjk:jk2075.
PATRICi21515142. VBICorJei31838_2105.

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiREKNDWE.
OrthoDBiEOG63Z74X.

Enzyme and pathway databases

BioCyciCJEI306537:GJ8V-2136-MONOMER.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 2 hits.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora."
    Tauch A., Kaiser O., Hain T., Goesmann A., Weisshaar B., Albersmeier A., Bekel T., Bischoff N., Brune I., Chakraborty T., Kalinowski J., Meyer F., Rupp O., Schneiker S., Viehoever P., Puehler A.
    J. Bacteriol. 187:4671-4682(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K411.

Entry informationi

Entry nameiSYL_CORJK
AccessioniPrimary (citable) accession number: Q4JSF0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 2, 2005
Last modified: June 24, 2015
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.