Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q4JSF0 (SYL_CORJK) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:jk2075
OrganismCorynebacterium jeikeium (strain K411) [Complete proteome] [HAMAP]
Taxonomic identifier306537 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium

Protein attributes

Sequence length976 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 976976Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_0000334746

Regions

Motif63 – 7412"HIGH" region HAMAP-Rule MF_00049
Motif745 – 7495"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site7481ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4JSF0 [UniParc].

Last modified August 2, 2005. Version 1.
Checksum: F70D707285B5C31E

FASTA976108,844
        10         20         30         40         50         60 
MTNGSTEDNS YRYTPGLAAK IEAKWQKHWA DKGTFNAPNP TGDLAEPGAE LPEDRKFIQD 

        70         80         90        100        110        120 
MFPYPSGVGL HVGHPLGYIG TDVFARFHRM KGANVLHTLG YDAFGLPAEQ YAVQTGTHPR 

       130        140        150        160        170        180 
TTTMANIANM ERQLGRLGLG HDKRRSFATT DTDYYRWTQW IFLQIYNSWF DPEAKNANGT 

       190        200        210        220        230        240 
LGKARPIKEL EEKLAAERAD WADLSAAEKQ EILDSYRLVY RSNSTVNWCP GLGTVLANEE 

       250        260        270        280        290        300 
VTAEGRSERG NFPVFRKNLQ QWMMRITAYS DRLIDDLEYL DWPEKVKSMQ RNWIGRSRGA 

       310        320        330        340        350        360 
EVTFDCLGND IDVFTTRPDT LFGATYMVLA PEHELVDTLV AQSGNSSSGS DAYTDVDPRW 

       370        380        390        400        410        420 
TYGQANPAAA VEAYRAAIAA KSDLERQENK EKTGVFLGVY ATNPVNGAQV PVFIADYVLT 

       430        440        450        460        470        480 
GYGTGAIMAV PAHDSRDFEF ATEFGLPIVP VLAPEGAEAG AGEQGGAELT EAFTEDGPHI 

       490        500        510        520        530        540 
NSNNSDGLEL NGLGKAEAID KAIEWLESKG VGSGKIQYKL RDWLFARQRY WGEPFPIVYD 

       550        560        570        580        590        600 
EDGTAHGLPE DMLPVELPEV EDYKPVSFDP DDKDSAPQPP LAKAKDWVEV TLDLGDGEKT 

       610        620        630        640        650        660 
YYRDTNVMPQ WAGSSWYQLR YIDPNNDNAL VDIENERYWV GPREGRPSGG VDLYVGGVEH 

       670        680        690        700        710        720 
AVLHLLYARF WHKVLFDLGV VSSFEPYYRL YNQGYIQAYA YTDSRGVYVP AEEVTERDGK 

       730        740        750        760        770        780 
FFWVRKADDA EGVTKEEEVF QEYGKMGKSL KNAVSPDEIC DDYGADTLRV YEMAMGPLDT 

       790        800        810        820        830        840 
SRPWATKDVV GAQRFLQRAW RLAVDENTGK GSVSDDALTD EDLKALHRTI AGVHENYAEL 

       850        860        870        880        890        900 
RDNTAVAKLI EYVNYLTKTY SAGQAPRAAV EPLVQMLSPV APHIAEEMWE ILGHSEGITY 

       910        920        930        940        950        960 
ESFPEWDEKW LVDDTIELPV QVMGKLRGRI NVAADASRED IEAAALEEPN VASHIEGKTV 

       970 
AKIIVVPGKM VNIVAK 

« Hide

References

[1]"Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora."
Tauch A., Kaiser O., Hain T., Goesmann A., Weisshaar B., Albersmeier A., Bekel T., Bischoff N., Brune I., Chakraborty T., Kalinowski J., Meyer F., Rupp O., Schneiker S., Viehoever P., Puehler A.
J. Bacteriol. 187:4671-4682(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K411.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR931997 Genomic DNA. Translation: CAI38257.1.
RefSeqYP_251875.1. NC_007164.1.

3D structure databases

ProteinModelPortalQ4JSF0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING306537.jk2075.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAI38257; CAI38257; jk2075.
GeneID3433565.
KEGGcjk:jk2075.
PATRIC21515142. VBICorJei31838_2105.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200748.
KOK01869.
OMAKGNPLES.
OrthoDBEOG63Z74X.

Enzyme and pathway databases

BioCycCJEI306537:GJ8V-2136-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 2 hits.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSYL_CORJK
AccessionPrimary (citable) accession number: Q4JSF0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 2, 2005
Last modified: May 14, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries