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Q4JSF0

- SYL_CORJK

UniProt

Q4JSF0 - SYL_CORJK

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Protein
Leucine--tRNA ligase
Gene
leuS, jk2075
Organism
Corynebacterium jeikeium (strain K411)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei748 – 7481ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCJEI306537:GJ8V-2136-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:jk2075
OrganismiCorynebacterium jeikeium (strain K411)
Taxonomic identifieri306537 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000000545: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 976976Leucine--tRNA ligaseUniRule annotation
PRO_0000334746Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi306537.jk2075.

Structurei

3D structure databases

ProteinModelPortaliQ4JSF0.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi63 – 7412"HIGH" regionUniRule annotation
Add
BLAST
Motifi745 – 7495"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiKGNPLES.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 2 hits.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4JSF0-1 [UniParc]FASTAAdd to Basket

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MTNGSTEDNS YRYTPGLAAK IEAKWQKHWA DKGTFNAPNP TGDLAEPGAE    50
LPEDRKFIQD MFPYPSGVGL HVGHPLGYIG TDVFARFHRM KGANVLHTLG 100
YDAFGLPAEQ YAVQTGTHPR TTTMANIANM ERQLGRLGLG HDKRRSFATT 150
DTDYYRWTQW IFLQIYNSWF DPEAKNANGT LGKARPIKEL EEKLAAERAD 200
WADLSAAEKQ EILDSYRLVY RSNSTVNWCP GLGTVLANEE VTAEGRSERG 250
NFPVFRKNLQ QWMMRITAYS DRLIDDLEYL DWPEKVKSMQ RNWIGRSRGA 300
EVTFDCLGND IDVFTTRPDT LFGATYMVLA PEHELVDTLV AQSGNSSSGS 350
DAYTDVDPRW TYGQANPAAA VEAYRAAIAA KSDLERQENK EKTGVFLGVY 400
ATNPVNGAQV PVFIADYVLT GYGTGAIMAV PAHDSRDFEF ATEFGLPIVP 450
VLAPEGAEAG AGEQGGAELT EAFTEDGPHI NSNNSDGLEL NGLGKAEAID 500
KAIEWLESKG VGSGKIQYKL RDWLFARQRY WGEPFPIVYD EDGTAHGLPE 550
DMLPVELPEV EDYKPVSFDP DDKDSAPQPP LAKAKDWVEV TLDLGDGEKT 600
YYRDTNVMPQ WAGSSWYQLR YIDPNNDNAL VDIENERYWV GPREGRPSGG 650
VDLYVGGVEH AVLHLLYARF WHKVLFDLGV VSSFEPYYRL YNQGYIQAYA 700
YTDSRGVYVP AEEVTERDGK FFWVRKADDA EGVTKEEEVF QEYGKMGKSL 750
KNAVSPDEIC DDYGADTLRV YEMAMGPLDT SRPWATKDVV GAQRFLQRAW 800
RLAVDENTGK GSVSDDALTD EDLKALHRTI AGVHENYAEL RDNTAVAKLI 850
EYVNYLTKTY SAGQAPRAAV EPLVQMLSPV APHIAEEMWE ILGHSEGITY 900
ESFPEWDEKW LVDDTIELPV QVMGKLRGRI NVAADASRED IEAAALEEPN 950
VASHIEGKTV AKIIVVPGKM VNIVAK 976
Length:976
Mass (Da):108,844
Last modified:August 2, 2005 - v1
Checksum:iF70D707285B5C31E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR931997 Genomic DNA. Translation: CAI38257.1.
RefSeqiYP_251875.1. NC_007164.1.

Genome annotation databases

EnsemblBacteriaiCAI38257; CAI38257; jk2075.
GeneIDi3433565.
KEGGicjk:jk2075.
PATRICi21515142. VBICorJei31838_2105.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR931997 Genomic DNA. Translation: CAI38257.1 .
RefSeqi YP_251875.1. NC_007164.1.

3D structure databases

ProteinModelPortali Q4JSF0.
ModBasei Search...

Protein-protein interaction databases

STRINGi 306537.jk2075.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAI38257 ; CAI38257 ; jk2075 .
GeneIDi 3433565.
KEGGi cjk:jk2075.
PATRICi 21515142. VBICorJei31838_2105.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi KGNPLES.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci CJEI306537:GJ8V-2136-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 2 hits.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora."
    Tauch A., Kaiser O., Hain T., Goesmann A., Weisshaar B., Albersmeier A., Bekel T., Bischoff N., Brune I., Chakraborty T., Kalinowski J., Meyer F., Rupp O., Schneiker S., Viehoever P., Puehler A.
    J. Bacteriol. 187:4671-4682(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K411.

Entry informationi

Entry nameiSYL_CORJK
AccessioniPrimary (citable) accession number: Q4JSF0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 2, 2005
Last modified: May 14, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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