Q4JQW7 (DUT_VZVO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase
Short name=dUTPase
EC=3.6.1.23

Alternative name(s):
dUTP pyrophosphatase

Gene names

ORF Names:

ORF8

Organism

Varicella-zoster virus (strain Oka vaccine) (HHV-3) (Human herpesvirus 3) [Complete proteome]

Taxonomic identifier

341980 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Varicellovirus › Human herpesvirus 3

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	396 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into viral DNA By similarity.
Catalytic activity	dUTP + H2O = dUMP + diphosphate.
Cofactor	Magnesium By similarity.
Sequence similarities	Belongs to the dUTPase family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Ligand	Magnesium Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dUTP metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	dUTP diphosphatase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 396	396	Deoxyuridine 5'-triphosphate nucleotidohydrolase		PRO_0000385168

Sequences

	Sequence		Length	Mass (Da)
	Q4JQW7 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: FD8E18ECACFC91F3	FASTA	396	44,809
	10 20 30 40 50 60 MNEAVIDPIL ETAVNTGDMF CSQTIPNRCL KDTILIEVQP ECADTLQCVL DDKVSRHQPL 70 80 90 100 110 120 LLRNHKKLEL PSEKSVTRGG FYMQQLELLV KSAPPNEYAL LLIQCKDTAL ADEDNFFVAN 130 140 150 160 170 180 GVIDAGYRGV ISALLYYRPG VTVILPGHLT IYLFPVKLRQ SRLLPKNVLK HLDPIFKSIQ 190 200 210 220 230 240 VQPLSNSPSN YEKPVISEFA DISTVQQGQP LHRDSAEYHI DVPLTYKHII NPKRQEDAGY 250 260 270 280 290 300 DICVPYNLYL KRNEFIKIVL PIIRDWDLQH PSINAYIFGR SSKSRSGIIV CPTAWPAGEH 310 320 330 340 350 360 CKFYVYNLTG DDIRIKTGDR LAQVLLIDHN TQIHLKHNVL SNIAFPYAIR GKCGIPGVQW 370 380 390 YFTKTLDLIA TPSERGTRGF GSTDKETNDV DFLLKH

References

[1]	"Comparison of the complete DNA sequences of the Oka varicella vaccine and its parental virus." Gomi Y., Sunamachi H., Mori Y., Nagaike K., Takahashi M., Yamanishi K. J. Virol. 76:11447-11459(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Isolate Human/Japan/P-Oka/1970 and Oka varicella vaccine Biken (V-Oka-Biken).
[2]	"Complete DNA sequences of two oka strain varicella-zoster virus genomes." Tillieux S.L., Halsey W.S., Thomas E.S., Voycik J.J., Sathe G.M., Vassilev V. J. Virol. 82:11023-11044(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Oka varicella vaccine VarilRix (V-Oka-GSK) and Oka varicella vaccine Varivax (V-Oka-Merk).
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB097932 Genomic DNA. No translation available. AB097933 Genomic DNA. No translation available. DQ008354 Genomic DNA. Translation: AAY57626.1. DQ008355 Genomic DNA. Translation: AAY57697.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q4JQW7. 6 interactions.
MINT	MINT-2828598.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR008180. dUTP_pyroPase. [Graphical view]
Pfam	PF00692. dUTPase. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DUT_VZVO

Accession

Primary (citable) accession number: Q4JQW7

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	August 2, 2005
Last modified:	March 21, 2012
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program