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Q4JQW7

- DUT_VZVO

UniProt

Q4JQW7 - DUT_VZVO

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Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

ORF8

Organism
Varicella-zoster virus (strain Oka vaccine) (HHV-3) (Human herpesvirus 3)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into viral DNA.By similarity

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.

Cofactori

Magnesium.By similarity

GO - Molecular functioni

  1. dUTP diphosphatase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. dUTP metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
Short name:
dUTPase
Alternative name(s):
dUTP pyrophosphatase
Gene namesi
ORF Names:ORF8
OrganismiVaricella-zoster virus (strain Oka vaccine) (HHV-3) (Human herpesvirus 3)
Taxonomic identifieri341980 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeVaricellovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000002603: Genome, UP000008504: Genome, UP000008505: Genome, UP000008506: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 396396Deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_0000385168Add
BLAST

Interactioni

Protein-protein interaction databases

IntActiQ4JQW7. 8 interactions.
MINTiMINT-2828598.

Family & Domainsi

Sequence similaritiesi

Belongs to the dUTPase family.Curated

Family and domain databases

Gene3Di2.70.40.10. 1 hit.
InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 3 hits.

Sequencei

Sequence statusi: Complete.

Q4JQW7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNEAVIDPIL ETAVNTGDMF CSQTIPNRCL KDTILIEVQP ECADTLQCVL
60 70 80 90 100
DDKVSRHQPL LLRNHKKLEL PSEKSVTRGG FYMQQLELLV KSAPPNEYAL
110 120 130 140 150
LLIQCKDTAL ADEDNFFVAN GVIDAGYRGV ISALLYYRPG VTVILPGHLT
160 170 180 190 200
IYLFPVKLRQ SRLLPKNVLK HLDPIFKSIQ VQPLSNSPSN YEKPVISEFA
210 220 230 240 250
DISTVQQGQP LHRDSAEYHI DVPLTYKHII NPKRQEDAGY DICVPYNLYL
260 270 280 290 300
KRNEFIKIVL PIIRDWDLQH PSINAYIFGR SSKSRSGIIV CPTAWPAGEH
310 320 330 340 350
CKFYVYNLTG DDIRIKTGDR LAQVLLIDHN TQIHLKHNVL SNIAFPYAIR
360 370 380 390
GKCGIPGVQW YFTKTLDLIA TPSERGTRGF GSTDKETNDV DFLLKH
Length:396
Mass (Da):44,809
Last modified:August 2, 2005 - v1
Checksum:iFD8E18ECACFC91F3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB097932 Genomic DNA. No translation available.
AB097933 Genomic DNA. No translation available.
DQ008354 Genomic DNA. Translation: AAY57626.1.
DQ008355 Genomic DNA. Translation: AAY57697.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB097932 Genomic DNA. No translation available.
AB097933 Genomic DNA. No translation available.
DQ008354 Genomic DNA. Translation: AAY57626.1 .
DQ008355 Genomic DNA. Translation: AAY57697.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q4JQW7. 8 interactions.
MINTi MINT-2828598.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.70.40.10. 1 hit.
InterProi IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
[Graphical view ]
Pfami PF00692. dUTPase. 1 hit.
[Graphical view ]
SUPFAMi SSF51283. SSF51283. 3 hits.
ProtoNeti Search...

Publicationsi

  1. "Comparison of the complete DNA sequences of the Oka varicella vaccine and its parental virus."
    Gomi Y., Sunamachi H., Mori Y., Nagaike K., Takahashi M., Yamanishi K.
    J. Virol. 76:11447-11459(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Isolate Human/Japan/P-Oka/1970 and Oka varicella vaccine Biken (V-Oka-Biken).
  2. "Complete DNA sequences of two oka strain varicella-zoster virus genomes."
    Tillieux S.L., Halsey W.S., Thomas E.S., Voycik J.J., Sathe G.M., Vassilev V.
    J. Virol. 82:11023-11044(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Oka varicella vaccine VarilRix (V-Oka-GSK) and Oka varicella vaccine Varivax (V-Oka-Merk).

Entry informationi

Entry nameiDUT_VZVO
AccessioniPrimary (citable) accession number: Q4JQW7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: August 2, 2005
Last modified: October 1, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3