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Q4JQW7 (DUT_VZVO) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase

Short name=dUTPase
EC=3.6.1.23
Alternative name(s):
dUTP pyrophosphatase
Gene names
ORF Names:ORF8
OrganismVaricella-zoster virus (strain Oka vaccine) (HHV-3) (Human herpesvirus 3) [Complete proteome]
Taxonomic identifier341980 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeVaricellovirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length396 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into viral DNA By similarity.

Catalytic activity

dUTP + H2O = dUMP + diphosphate.

Cofactor

Magnesium By similarity.

Sequence similarities

Belongs to the dUTPase family.

Ontologies

Keywords
   Biological processNucleotide metabolism
   LigandMagnesium
Metal-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processdUTP metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functiondUTP diphosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 396396Deoxyuridine 5'-triphosphate nucleotidohydrolase
PRO_0000385168

Sequences

Sequence LengthMass (Da)Tools
Q4JQW7 [UniParc].

Last modified August 2, 2005. Version 1.
Checksum: FD8E18ECACFC91F3

FASTA39644,809
        10         20         30         40         50         60 
MNEAVIDPIL ETAVNTGDMF CSQTIPNRCL KDTILIEVQP ECADTLQCVL DDKVSRHQPL 

        70         80         90        100        110        120 
LLRNHKKLEL PSEKSVTRGG FYMQQLELLV KSAPPNEYAL LLIQCKDTAL ADEDNFFVAN 

       130        140        150        160        170        180 
GVIDAGYRGV ISALLYYRPG VTVILPGHLT IYLFPVKLRQ SRLLPKNVLK HLDPIFKSIQ 

       190        200        210        220        230        240 
VQPLSNSPSN YEKPVISEFA DISTVQQGQP LHRDSAEYHI DVPLTYKHII NPKRQEDAGY 

       250        260        270        280        290        300 
DICVPYNLYL KRNEFIKIVL PIIRDWDLQH PSINAYIFGR SSKSRSGIIV CPTAWPAGEH 

       310        320        330        340        350        360 
CKFYVYNLTG DDIRIKTGDR LAQVLLIDHN TQIHLKHNVL SNIAFPYAIR GKCGIPGVQW 

       370        380        390 
YFTKTLDLIA TPSERGTRGF GSTDKETNDV DFLLKH 

« Hide

References

[1]"Comparison of the complete DNA sequences of the Oka varicella vaccine and its parental virus."
Gomi Y., Sunamachi H., Mori Y., Nagaike K., Takahashi M., Yamanishi K.
J. Virol. 76:11447-11459(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Isolate Human/Japan/P-Oka/1970 and Oka varicella vaccine Biken (V-Oka-Biken).
[2]"Complete DNA sequences of two oka strain varicella-zoster virus genomes."
Tillieux S.L., Halsey W.S., Thomas E.S., Voycik J.J., Sathe G.M., Vassilev V.
J. Virol. 82:11023-11044(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Oka varicella vaccine VarilRix (V-Oka-GSK) and Oka varicella vaccine Varivax (V-Oka-Merk).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB097932 Genomic DNA. No translation available.
AB097933 Genomic DNA. No translation available.
DQ008354 Genomic DNA. Translation: AAY57626.1.
DQ008355 Genomic DNA. Translation: AAY57697.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ4JQW7. 8 interactions.
MINTMINT-2828598.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR008180. dUTP_pyroPase.
[Graphical view]
PfamPF00692. dUTPase. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDUT_VZVO
AccessionPrimary (citable) accession number: Q4JQW7
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: August 2, 2005
Last modified: November 13, 2013
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families