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Q4JQW2 (TYSY_VZVO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidylate synthase

Short name=TS
Short name=TSase
EC=2.1.1.45
Gene names
ORF Names:ORF13
OrganismVaricella-zoster virus (strain Oka vaccine) (HHV-3) (Human herpesvirus 3) [Complete proteome]
Taxonomic identifier341980 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeVaricellovirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length301 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reductive methylation of deoxyuridylate to thymidylate By similarity. HAMAP-Rule MF_00008

Catalytic activity

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP. HAMAP-Rule MF_00008

Pathway

Pyrimidine metabolism; dTTP biosynthesis. HAMAP-Rule MF_00008

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00008

Sequence similarities

Belongs to the thymidylate synthase family.

Ontologies

Keywords
   Biological processNucleotide biosynthesis
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processdTMP biosynthetic process

Inferred from electronic annotation. Source: InterPro

dTTP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionthymidylate synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 301301Thymidylate synthase HAMAP-Rule MF_00008
PRO_0000385165

Sites

Active site1831 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4JQW2 [UniParc].

Last modified March 24, 2009. Version 1.
Checksum: 8B84C36E79F95861

FASTA30134,533
        10         20         30         40         50         60 
MGDLSCWTKV PGFTLTGELQ YLKQVDDILR YGVRKRDRTG IGTLSLFGMQ ARYNLRNEFP 

        70         80         90        100        110        120 
LLTTKRVFWR AVVEELLWFI RGSTDSKELA AKDIHIWDIY GSSKFLNRNG FHKRHTGDLG 

       130        140        150        160        170        180 
PIYGFQWRHF GAEYKDCQSN YLQQGIDQLQ TVIDTIKTNP ESRRMIISSW NPKDIPLMVL 

       190        200        210        220        230        240 
PPCHTLCQFY VANGELSCQV YQRSGDMGLG VPFNIAGYAL LTYIVAHVTG LKTGDLIHTM 

       250        260        270        280        290        300 
GDAHIYLNHI DALKVQLARS PKPFPCLKII RNVTDINDFK WDDFQLDGYN PHPPLKMEMA 


L 

« Hide

References

[1]"Comparison of the complete DNA sequences of the Oka varicella vaccine and its parental virus."
Gomi Y., Sunamachi H., Mori Y., Nagaike K., Takahashi M., Yamanishi K.
J. Virol. 76:11447-11459(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Isolate Human/Japan/P-Oka/1970 and Oka varicella vaccine Biken (V-Oka-Biken).
[2]"Complete DNA sequences of two oka strain varicella-zoster virus genomes."
Tillieux S.L., Halsey W.S., Thomas E.S., Voycik J.J., Sathe G.M., Vassilev V.
J. Virol. 82:11023-11044(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Oka varicella vaccine VarilRix (V-Oka-GSK) and Oka varicella vaccine Varivax (V-Oka-Merk).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB097932 Genomic DNA. No translation available.
AB097933 Genomic DNA. No translation available.
DQ008354 Genomic DNA. Translation: AAY57630.1.
DQ008355 Genomic DNA. Translation: AAY57701.1.
RefSeqNP_040136.1. NC_001348.1.

3D structure databases

ProteinModelPortalQ4JQW2.
SMRQ4JQW2. Positions 17-301.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ4JQW2. 2 interactions.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1487659.

Enzyme and pathway databases

UniPathwayUPA00575.

Family and domain databases

Gene3D3.30.572.10. 1 hit.
HAMAPMF_00008. Thymidy_synth_bact.
InterProIPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view]
PfamPF00303. Thymidylat_synt. 1 hit.
[Graphical view]
PRINTSPR00108. THYMDSNTHASE.
SUPFAMSSF55831. SSF55831. 1 hit.
TIGRFAMsTIGR03284. thym_sym. 1 hit.
PROSITEPS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTYSY_VZVO
AccessionPrimary (citable) accession number: Q4JQW2
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: March 24, 2009
Last modified: May 14, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways