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Q4JQW2

- TYSY_VZVO

UniProt

Q4JQW2 - TYSY_VZVO

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Protein

Thymidylate synthase

Gene
ORF13
Organism
Varicella-zoster virus (strain Oka vaccine) (HHV-3) (Human herpesvirus 3)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reductive methylation of deoxyuridylate to thymidylate By similarity.UniRule annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei183 – 1831 By similarity

GO - Molecular functioni

  1. thymidylate synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. dTMP biosynthetic process Source: InterPro
  2. dTTP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00575.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate synthase (EC:2.1.1.45)
Short name:
TS
Short name:
TSase
Gene namesi
ORF Names:ORF13
OrganismiVaricella-zoster virus (strain Oka vaccine) (HHV-3) (Human herpesvirus 3)
Taxonomic identifieri341980 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeVaricellovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000002603: Genome, UP000008504: Genome, UP000008505: Genome, UP000008506: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 301301Thymidylate synthaseUniRule annotationPRO_0000385165Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

IntActiQ4JQW2. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ4JQW2.
SMRiQ4JQW2. Positions 17-301.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.30.572.10. 1 hit.
HAMAPiMF_00008. Thymidy_synth_bact.
InterProiIPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view]
PfamiPF00303. Thymidylat_synt. 1 hit.
[Graphical view]
PRINTSiPR00108. THYMDSNTHASE.
SUPFAMiSSF55831. SSF55831. 1 hit.
TIGRFAMsiTIGR03284. thym_sym. 1 hit.
PROSITEiPS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4JQW2-1 [UniParc]FASTAAdd to Basket

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MGDLSCWTKV PGFTLTGELQ YLKQVDDILR YGVRKRDRTG IGTLSLFGMQ    50
ARYNLRNEFP LLTTKRVFWR AVVEELLWFI RGSTDSKELA AKDIHIWDIY 100
GSSKFLNRNG FHKRHTGDLG PIYGFQWRHF GAEYKDCQSN YLQQGIDQLQ 150
TVIDTIKTNP ESRRMIISSW NPKDIPLMVL PPCHTLCQFY VANGELSCQV 200
YQRSGDMGLG VPFNIAGYAL LTYIVAHVTG LKTGDLIHTM GDAHIYLNHI 250
DALKVQLARS PKPFPCLKII RNVTDINDFK WDDFQLDGYN PHPPLKMEMA 300
L 301
Length:301
Mass (Da):34,533
Last modified:March 24, 2009 - v1
Checksum:i8B84C36E79F95861
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB097932 Genomic DNA. No translation available.
AB097933 Genomic DNA. No translation available.
DQ008354 Genomic DNA. Translation: AAY57630.1.
DQ008355 Genomic DNA. Translation: AAY57701.1.
RefSeqiNP_040136.1. NC_001348.1.

Genome annotation databases

GeneIDi1487659.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB097932 Genomic DNA. No translation available.
AB097933 Genomic DNA. No translation available.
DQ008354 Genomic DNA. Translation: AAY57630.1 .
DQ008355 Genomic DNA. Translation: AAY57701.1 .
RefSeqi NP_040136.1. NC_001348.1.

3D structure databases

ProteinModelPortali Q4JQW2.
SMRi Q4JQW2. Positions 17-301.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q4JQW2. 2 interactions.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1487659.

Enzyme and pathway databases

UniPathwayi UPA00575 .

Family and domain databases

Gene3Di 3.30.572.10. 1 hit.
HAMAPi MF_00008. Thymidy_synth_bact.
InterProi IPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view ]
Pfami PF00303. Thymidylat_synt. 1 hit.
[Graphical view ]
PRINTSi PR00108. THYMDSNTHASE.
SUPFAMi SSF55831. SSF55831. 1 hit.
TIGRFAMsi TIGR03284. thym_sym. 1 hit.
PROSITEi PS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparison of the complete DNA sequences of the Oka varicella vaccine and its parental virus."
    Gomi Y., Sunamachi H., Mori Y., Nagaike K., Takahashi M., Yamanishi K.
    J. Virol. 76:11447-11459(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Isolate Human/Japan/P-Oka/1970 and Oka varicella vaccine Biken (V-Oka-Biken).
  2. "Complete DNA sequences of two oka strain varicella-zoster virus genomes."
    Tillieux S.L., Halsey W.S., Thomas E.S., Voycik J.J., Sathe G.M., Vassilev V.
    J. Virol. 82:11023-11044(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Oka varicella vaccine VarilRix (V-Oka-GSK) and Oka varicella vaccine Varivax (V-Oka-Merk).

Entry informationi

Entry nameiTYSY_VZVO
AccessioniPrimary (citable) accession number: Q4JQW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: March 24, 2009
Last modified: May 14, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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