Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q4JQV7 (RIR2_VZVO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonucleoside-diphosphate reductase small chain

Short name=R2
EC=1.17.4.1
Alternative name(s):
Ribonucleotide reductase small subunit
Gene names
ORF Names:ORF18
OrganismVaricella-zoster virus (strain Oka vaccine) (HHV-3) (Human herpesvirus 3) [Complete proteome]
Taxonomic identifier341980 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeVaricellovirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length306 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. The N-terminal region confers antiapoptotic activity in differentiated cells such as neurons and is important for viral reactivation to increase neural survivability By similarity.

Catalytic activity

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactor

Binds 2 iron ions per subunit By similarity.

Pathway

Genetic information processing; DNA replication.

Subunit structure

Heterotetramer composed of a homodimer of the large subunit ORF19 (R1) and a homodimer of the small subunit ORF18 (R2). Larger multisubunit protein complex are also active, composed of (R1)n(R2)n By similarity.

Subcellular location

Host membrane; Single-pass membrane protein Potential.

Sequence similarities

Belongs to the ribonucleoside diphosphate reductase small chain family.

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 306306Ribonucleoside-diphosphate reductase small chain
PRO_0000385164

Regions

Transmembrane153 – 17321Helical; Potential

Sites

Active site1031 By similarity
Metal binding661Iron 1 By similarity
Metal binding961Iron 1 By similarity
Metal binding961Iron 2 By similarity
Metal binding991Iron 1 By similarity
Metal binding1591Iron 2 By similarity
Metal binding1931Iron 2 By similarity
Metal binding1961Iron 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4JQV7 [UniParc].

Last modified March 24, 2009. Version 1.
Checksum: 76CD3F8BB8C1B094

FASTA30635,397
        10         20         30         40         50         60 
MDQKDCSHFF YRPECPDINN LRALSISNRW LESDFIIEDD YQYLDCLTED ELIFYRFIFT 

        70         80         90        100        110        120 
FLSAADDLVN VNLGSLTQLF SQKDIHHYYI EQECIEVVHA RVYSQIQLML FRGDESLRVQ 

       130        140        150        160        170        180 
YVNVTINNPS IQQKVQWLEE KVRDNPSVAE KYILMILIEG IFFVSSFAAI AYLRNNGLFV 

       190        200        210        220        230        240 
VTCQFNDLIS RDEAIHTSAS CCIYNNYVPE KPAITRIHQL FSEAVEIECA FLKSHAPKTR 

       250        260        270        280        290        300 
LVNVDAITQY VKFSADRLLS AINVPKLFNT PPPDSDFPLA FMIADKNTNF FERHSTSYAG 


TVINDL 

« Hide

References

« Hide 'large scale' references
[1]"Comparison of the complete DNA sequences of the Oka varicella vaccine and its parental virus."
Gomi Y., Sunamachi H., Mori Y., Nagaike K., Takahashi M., Yamanishi K.
J. Virol. 76:11447-11459(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Isolate Human/Japan/P-Oka/1970 and Oka varicella vaccine Biken (V-Oka-Biken).
[2]"Complete DNA sequences of two oka strain varicella-zoster virus genomes."
Tillieux S.L., Halsey W.S., Thomas E.S., Voycik J.J., Sathe G.M., Vassilev V.
J. Virol. 82:11023-11044(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Oka varicella vaccine VarilRix (V-Oka-GSK) and Oka varicella vaccine Varivax (V-Oka-Merk).
[3]"Tinkering with a viral ribonucleotide reductase."
Lembo D., Brune W.
Trends Biochem. Sci. 34:25-32(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB097932 Genomic DNA. No translation available.
AB097933 Genomic DNA. No translation available.
DQ008354 Genomic DNA. Translation: AAY57634.1.
DQ008355 Genomic DNA. Translation: AAY57705.1.
RefSeqNP_040141.1. NC_001348.1.

3D structure databases

ProteinModelPortalQ4JQV7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ4JQV7. 22 interactions.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1487715.

Phylogenomic databases

ProtClustDBCLSP2509600.

Enzyme and pathway databases

UniPathwayUPA00326.

Family and domain databases

Gene3D1.10.620.20. 1 hit.
InterProIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERPTHR23409. PTHR23409. 1 hit.
PfamPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMSSF47240. SSF47240. 1 hit.
PROSITEPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRIR2_VZVO
AccessionPrimary (citable) accession number: Q4JQV7
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: March 24, 2009
Last modified: February 19, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways