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Q4JQV7

- RIR2_VZVO

UniProt

Q4JQV7 - RIR2_VZVO

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Protein

Ribonucleoside-diphosphate reductase small chain

Gene
ORF18
Organism
Varicella-zoster virus (strain Oka vaccine) (HHV-3) (Human herpesvirus 3)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. The N-terminal region confers antiapoptotic activity in differentiated cells such as neurons and is important for viral reactivation to increase neural survivability By similarity.

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactori

Binds 2 iron ions per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi66 – 661Iron 1 By similarity
Metal bindingi96 – 961Iron 1 By similarity
Metal bindingi96 – 961Iron 2 By similarity
Metal bindingi99 – 991Iron 1 By similarity
Active sitei103 – 1031 By similarity
Metal bindingi159 – 1591Iron 2 By similarity
Metal bindingi193 – 1931Iron 2 By similarity
Metal bindingi196 – 1961Iron 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein binding Source: IntAct
  3. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

GO - Biological processi

  1. deoxyribonucleoside diphosphate metabolic process Source: InterPro
  2. DNA replication Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase small chain (EC:1.17.4.1)
Short name:
R2
Alternative name(s):
Ribonucleotide reductase small subunit
Gene namesi
ORF Names:ORF18
OrganismiVaricella-zoster virus (strain Oka vaccine) (HHV-3) (Human herpesvirus 3)
Taxonomic identifieri341980 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeVaricellovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000002603: Genome, UP000008504: Genome, UP000008505: Genome, UP000008506: Genome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei153 – 17321Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. host cell membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 306306Ribonucleoside-diphosphate reductase small chainPRO_0000385164Add
BLAST

Interactioni

Subunit structurei

Heterotetramer composed of a homodimer of the large subunit ORF19 (R1) and a homodimer of the small subunit ORF18 (R2). Larger multisubunit protein complex are also active, composed of (R1)n(R2)n By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
ORF23Q4JQV23EBI-2532450,EBI-2532547
ORF26Q4JQU93EBI-2532450,EBI-2532467

Protein-protein interaction databases

IntActiQ4JQV7. 22 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ4JQV7.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4JQV7-1 [UniParc]FASTAAdd to Basket

« Hide

MDQKDCSHFF YRPECPDINN LRALSISNRW LESDFIIEDD YQYLDCLTED    50
ELIFYRFIFT FLSAADDLVN VNLGSLTQLF SQKDIHHYYI EQECIEVVHA 100
RVYSQIQLML FRGDESLRVQ YVNVTINNPS IQQKVQWLEE KVRDNPSVAE 150
KYILMILIEG IFFVSSFAAI AYLRNNGLFV VTCQFNDLIS RDEAIHTSAS 200
CCIYNNYVPE KPAITRIHQL FSEAVEIECA FLKSHAPKTR LVNVDAITQY 250
VKFSADRLLS AINVPKLFNT PPPDSDFPLA FMIADKNTNF FERHSTSYAG 300
TVINDL 306
Length:306
Mass (Da):35,397
Last modified:March 24, 2009 - v1
Checksum:i76CD3F8BB8C1B094
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB097932 Genomic DNA. No translation available.
AB097933 Genomic DNA. No translation available.
DQ008354 Genomic DNA. Translation: AAY57634.1.
DQ008355 Genomic DNA. Translation: AAY57705.1.
RefSeqiNP_040141.1. NC_001348.1.

Genome annotation databases

GeneIDi1487715.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB097932 Genomic DNA. No translation available.
AB097933 Genomic DNA. No translation available.
DQ008354 Genomic DNA. Translation: AAY57634.1 .
DQ008355 Genomic DNA. Translation: AAY57705.1 .
RefSeqi NP_040141.1. NC_001348.1.

3D structure databases

ProteinModelPortali Q4JQV7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q4JQV7. 22 interactions.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1487715.

Enzyme and pathway databases

UniPathwayi UPA00326 .

Family and domain databases

Gene3Di 1.10.620.20. 1 hit.
InterProi IPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view ]
PANTHERi PTHR23409. PTHR23409. 1 hit.
Pfami PF00268. Ribonuc_red_sm. 1 hit.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS00368. RIBORED_SMALL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Comparison of the complete DNA sequences of the Oka varicella vaccine and its parental virus."
    Gomi Y., Sunamachi H., Mori Y., Nagaike K., Takahashi M., Yamanishi K.
    J. Virol. 76:11447-11459(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Isolate Human/Japan/P-Oka/1970 and Oka varicella vaccine Biken (V-Oka-Biken).
  2. "Complete DNA sequences of two oka strain varicella-zoster virus genomes."
    Tillieux S.L., Halsey W.S., Thomas E.S., Voycik J.J., Sathe G.M., Vassilev V.
    J. Virol. 82:11023-11044(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Oka varicella vaccine VarilRix (V-Oka-GSK) and Oka varicella vaccine Varivax (V-Oka-Merk).
  3. "Tinkering with a viral ribonucleotide reductase."
    Lembo D., Brune W.
    Trends Biochem. Sci. 34:25-32(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiRIR2_VZVO
AccessioniPrimary (citable) accession number: Q4JQV7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: March 24, 2009
Last modified: June 11, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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