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Q4JQI4 (COX2_TETNG) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:mt-co2
Synonyms:coii, coxii, mtco2
Encoded onMitochondrion
OrganismTetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) [Reference proteome]
Taxonomic identifier99883 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiEuteleosteiNeoteleosteiAcanthomorphaAcanthopterygiiPercomorphaTetraodontiformesTetradontoideaTetraodontidaeTetraodon

Protein attributes

Sequence length230 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 230230Cytochrome c oxidase subunit 2
PRO_0000183702

Regions

Topological domain1 – 2626Mitochondrial intermembrane Potential
Transmembrane27 – 4822Helical; Probable
Topological domain49 – 6214Mitochondrial matrix Potential
Transmembrane63 – 8220Helical; Probable
Topological domain83 – 230148Mitochondrial intermembrane Potential

Sites

Metal binding1611Copper A Probable
Metal binding1961Copper A Probable
Metal binding2001Copper A Probable
Metal binding2041Copper A Probable

Sequences

Sequence LengthMass (Da)Tools
Q4JQI4 [UniParc].

Last modified August 2, 2005. Version 1.
Checksum: 774E06637300CC15

FASTA23026,051
        10         20         30         40         50         60 
MAHPSQLGFQ DAASPVMEEL LHFHDHALMI VFLISTLVLY IIAATASTKL TDKYILDSQE 

        70         80         90        100        110        120 
IEVIWTIMPA VILILIALPS LRILYLMDEI NDPHLTVKTM GHQWYWSYEY TDYDDLSFDS 

       130        140        150        160        170        180 
YMIPTQDLTP GQFRLLETDH RMVIPVDSPI RVLVSAEDVL HSWAVPSLGI KMDAVPGRLN 

       190        200        210        220        230 
QTAFIVSRPG VFYGQCSEIC GANHSFMPIV VEAVPLEHFE NWSSLMLEDA 

« Hide

References

[1]"The complete nucleotide sequence of the mitochondrial genome of Tetraodon nigroviridis."
Yue G.H., Lo L.C., Zhu Z.Y., Lin G., Feng F.
DNA Seq. 17:115-121(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ019313 Genomic DNA. Translation: AAY26161.1.
RefSeqYP_254664.1. NC_007176.1.

3D structure databases

ProteinModelPortalQ4JQI4.
SMRQ4JQI4. Positions 1-227.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSTNIT00000004109; ENSTNIP00000002153; ENSTNIG00000000112.
GeneID3453251.

Organism-specific databases

CTD4513.

Phylogenomic databases

eggNOGCOG1622.
GeneTreeENSGT00390000017410.
HOVERGENHBG012727.
OMAEDVLHSW.
OrthoDBEOG7TJ3JX.
TreeFamTF344269.

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsTIGR02866. CoxB. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_TETNG
AccessionPrimary (citable) accession number: Q4JQI4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: August 2, 2005
Last modified: April 16, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families