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Q4JQI4

- COX2_TETNG

UniProt

Q4JQI4 - COX2_TETNG

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Protein

Cytochrome c oxidase subunit 2

Gene

mt-co2

Organism
Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi161 – 1611Copper ACurated
Metal bindingi196 – 1961Copper ACurated
Metal bindingi200 – 2001Copper ACurated
Metal bindingi204 – 2041Copper ACurated

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:mt-co2
Synonyms:coii, coxii, mtco2
Encoded oniMitochondrion
OrganismiTetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)
Taxonomic identifieri99883 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaTetraodontiformesTetradontoideaTetraodontidaeTetraodon
ProteomesiUP000007303: Mitochondrion

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Transmembranei27 – 4822HelicalCuratedAdd
BLAST
Topological domaini49 – 6214Mitochondrial matrixSequence AnalysisAdd
BLAST
Transmembranei63 – 8220HelicalCuratedAdd
BLAST
Topological domaini83 – 230148Mitochondrial intermembraneSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
  3. respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 230230Cytochrome c oxidase subunit 2PRO_0000183702Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ4JQI4.
SMRiQ4JQI4. Positions 1-227.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1622.
GeneTreeiENSGT00390000017410.
HOVERGENiHBG012727.
InParanoidiQ4JQI4.
OMAiDHALMIV.
OrthoDBiEOG7TJ3JX.
TreeFamiTF344269.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4JQI4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAHPSQLGFQ DAASPVMEEL LHFHDHALMI VFLISTLVLY IIAATASTKL
60 70 80 90 100
TDKYILDSQE IEVIWTIMPA VILILIALPS LRILYLMDEI NDPHLTVKTM
110 120 130 140 150
GHQWYWSYEY TDYDDLSFDS YMIPTQDLTP GQFRLLETDH RMVIPVDSPI
160 170 180 190 200
RVLVSAEDVL HSWAVPSLGI KMDAVPGRLN QTAFIVSRPG VFYGQCSEIC
210 220 230
GANHSFMPIV VEAVPLEHFE NWSSLMLEDA
Length:230
Mass (Da):26,051
Last modified:August 2, 2005 - v1
Checksum:i774E06637300CC15
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ019313 Genomic DNA. Translation: AAY26161.1.
RefSeqiYP_254664.1. NC_007176.1.

Genome annotation databases

EnsembliENSTNIT00000004109; ENSTNIP00000002153; ENSTNIG00000000112.
GeneIDi3453251.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ019313 Genomic DNA. Translation: AAY26161.1 .
RefSeqi YP_254664.1. NC_007176.1.

3D structure databases

ProteinModelPortali Q4JQI4.
SMRi Q4JQI4. Positions 1-227.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSTNIT00000004109 ; ENSTNIP00000002153 ; ENSTNIG00000000112 .
GeneIDi 3453251.

Organism-specific databases

CTDi 4513.

Phylogenomic databases

eggNOGi COG1622.
GeneTreei ENSGT00390000017410.
HOVERGENi HBG012727.
InParanoidi Q4JQI4.
OMAi DHALMIV.
OrthoDBi EOG7TJ3JX.
TreeFami TF344269.

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsi TIGR02866. CoxB. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete nucleotide sequence of the mitochondrial genome of Tetraodon nigroviridis."
    Yue G.H., Lo L.C., Zhu Z.Y., Lin G., Feng F.
    DNA Seq. 17:115-121(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiCOX2_TETNG
AccessioniPrimary (citable) accession number: Q4JQI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: August 2, 2005
Last modified: November 26, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3