Q4JLT0 (Q4JLT0_DANRE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Protein Wnt RuleBase RU003503

Gene names

Name:	wnt7a ZFIN ZDB-GENE-051129-1
Synonyms:	wnt7aa Ensembl ENSDARP00000065888

Organism

Danio rerio (Zebrafish) (Brachydanio rerio) EMBL AAY85182.1

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	349 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Ligand for members of the frizzled family of seven transmembrane receptors By similarity. RuleBase RU003500
Subcellular location	Secreted › extracellular space › extracellular matrix By similarity RuleBase RU003500.
Sequence similarities	Belongs to the Wnt family. RuleBase RU003500

Ontologies

Keywords
Biological process	Wnt signaling pathway SAAS SAAS005817 RuleBase RU003500
Cellular component	Extracellular matrix SAAS SAAS005817 Secreted
Molecular function	Developmental protein SAAS SAAS005817 RuleBase RU003500
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	Wnt receptor signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW activation of JUN kinase activity Inferred from Biological aspect of Ancestor. Source: RefGenome anterior/posterior pattern specification Inferred from Biological aspect of Ancestor. Source: RefGenome axis specification Inferred from Biological aspect of Ancestor. Source: RefGenome central nervous system vasculogenesis Inferred from Biological aspect of Ancestor. Source: RefGenome cerebellar granule cell differentiation Inferred from Biological aspect of Ancestor. Source: RefGenome dorsal/ventral pattern formation Inferred from Biological aspect of Ancestor. Source: RefGenome embryonic forelimb morphogenesis Inferred from Biological aspect of Ancestor. Source: RefGenome positive regulation of JNK cascade Inferred from Biological aspect of Ancestor. Source: RefGenome positive regulation of canonical Wnt receptor signaling pathway Inferred from Biological aspect of Ancestor. Source: RefGenome positive regulation of synapse assembly Inferred from Biological aspect of Ancestor. Source: RefGenome regulation of axon diameter Inferred from Biological aspect of Ancestor. Source: RefGenome satellite cell activation Inferred from Biological aspect of Ancestor. Source: RefGenome satellite cell maintenance involved in skeletal muscle regeneration Inferred from Biological aspect of Ancestor. Source: RefGenome skeletal system development Inferred from Biological aspect of Ancestor. Source: RefGenome uterus development Inferred from Biological aspect of Ancestor. Source: RefGenome
Cellular component	extracellular space Inferred from Biological aspect of Ancestor. Source: RefGenome plasma membrane Inferred from Biological aspect of Ancestor. Source: RefGenome proteinaceous extracellular matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	frizzled binding Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q4JLT0 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: A62EBCA0F2495F11	FASTA	349	39,291
	10 20 30 40 50 60 MSRKTRRWIF HIFLCLGIIY LKIGGFSSVV ALGASIICNK IPGLAPRQRT ICQSRPDAII 70 80 90 100 110 120 VIGEGAQMGI NECQFQFKNG RWNCSALGER TVFGKELKVG SKEAAFTYAI IAAGVAHAIT 130 140 150 160 170 180 AACTQGTLSG CGCDKEKQGF YNQEEGWKWG GCSADIRYGL SFSKVFLDAR EIKQNARTLM 190 200 210 220 230 240 NLHNNEVGRK ILEKNMRLEC KCHGVSGSCT TKTCWTTLPK FRQLGYILKE RYNHAVHVEP 250 260 270 280 290 300 VRASRNKRPA FLKVKKPYSY RKPMDTDLVY IEKSPNYCEA DPVTGSMGTQ GRICNKTAQH 310 320 330 340 TNGCDLMCCG RGYNTHQYSR VWQCNCKFLW CCYVKCNTCS ERTEVYTCK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"HSPG synthesis by zebrafish Ext2 and Extl3 is required for Fgf10 signalling during limb development." Norton W.H.J., Ledin J., Grandel H., Neumann C.J. Development 132:4963-4973(2005) [PubMed: 16221725] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pooled EMBL AAI63690.1.
[3]	"The genomic sequence of Danio rerio." The Danio rerio Sequencing Project at the Sanger Institute Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tuebingen Ensembl ENSDARP00000065888.
[4]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: Tuebingen Ensembl ENSDARP00000065888.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR548622 Genomic DNA. No translation available. BC163690 mRNA. Translation: AAI63690.1. BC163691 mRNA. Translation: AAI63691.1. DQ074644 mRNA. Translation: AAY85182.1.
IPI	IPI00628153.
RefSeq	NP_001020711.1. NM_001025540.1.
UniGene	Dr.40153.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q4JLT0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSDART00000065889; ENSDARP00000065888; ENSDARG00000044827.
GeneID	565714.
KEGG	dre:565714.
NMPDR	fig|7955.3.peg.2768.
Organism-specific databases
CTD	565714.
ZFIN	ZDB-GENE-051129-1. wnt7aa.
Phylogenomic databases
eggNOG	fiNOG04120.
GeneTree	ENSGT00600000084153.
HOGENOM	HBG446188.
HOVERGEN	HBG001595.
InParanoid	Q4JLT0.
OrthoDB	EOG4GXFMZ.
Gene expression databases
Bgee	Q4JLT0.
Family and domain databases
InterPro	IPR005817. Wnt. IPR013300. Wnt7. IPR018161. Wnt_grthfactor_CS. [Graphical view]
KO	K00572.
PANTHER	PTHR12027. Wnt. 1 hit.
Pfam	PF00110. wnt. 1 hit. [Graphical view]
PRINTS	PR01891. WNT7PROTEIN. PR01349. WNTPROTEIN.
SMART	SM00097. WNT1. 1 hit. [Graphical view]
PROSITE	PS00246. WNT1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q4JLT0_DANRE

Accession

Primary (citable) accession number: Q4JLT0

Entry history

Integrated into UniProtKB/TrEMBL:	August 2, 2005
Last sequence update:	August 2, 2005
Last modified:	January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)