Reviewed, UniProtKB/Swiss-Prot Q4JK73 (DHB11_MACFA)

Names and origin

Protein names

Recommended name:
    Estradiol 17-beta-dehydrogenase 11
    EC=1.1.1.62
Alternative name(s):
    17-beta-hydroxysteroid dehydrogenase 11
      Short name=17-beta-HSD 11
      Short name=17betaHSD11
      Short name=17bHSD11
    17-beta-HSD XI
      Short name=17betaHSDXI
    Dehydrogenase/reductase SDR family member 8

Gene names

Name:	HSD17B11
Synonyms:	DHRS8

Organism

Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey)

Taxonomic identifier

9541 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length	300 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione By similarity.
Catalytic activity	Estradiol-17-beta + NAD(P)(+) = estrone + NAD(P)H.
Subcellular location	SecretedPotential.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.

Ontologies

Keywords
Biological process	Lipid synthesis Steroid biosynthesis
Cellular component	Secreted
Domain	Signal
Ligand	NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW steroid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro estradiol 17-beta-dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Chain	19 – 300	282	Estradiol 17-beta-dehydrogenase 11		PRO_0000042582
Regions
	Nucleotide binding	40 – 67	28	NADP By similarity
Sites
	Active site	185	1	Proton acceptor By similarity
	Binding site	172	1	Substrate By similarity
	Binding site	189	1	NADP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4JK73-1 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: 25B38CCF2A8A5D8D	FASTA	300	32,920
	10 20 30 40 50 60 MKILLDLLLL LPLLIVCCLE SFVKLFIPKR RKSVAGEIVL ITGAGHGIGR LTAYEFAKLK 70 80 90 100 110 120 SKLVLWDINK HGLEETAAKC KGLGAKVYTF VVDCSNREDI YSSAKKVKAE IGDVSILVNN 130 140 150 160 170 180 AGVVYTSDLF ATQDAQIEKT FEVNILAHFW TTKAFLPAMM KNNHGHVVTV ASAAGHISVP 190 200 210 220 230 240 FLLAYCSSKF SAVGFHKALT DELAALQITG VKTTCLCPNF VNTGFIKNPS TSLGPALEPE 250 260 270 280 290 300 EVVNRLMNGI LTEQKMIFSP SSIAFLTILE RILPERFLAV LKRKINIKFD AVIGYKMKAQ

References

[1]	Liu H., Labrie F., Luu-The V. Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	DQ078724 mRNA. Translation: AAY84570.1.
3D structure databases
SMR	Q4JK73. Positions 30-273.
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q4JK73.
Family and domain databases
InterPro	IPR002198. DHase_sc/Rdtase_SDR. IPR002347. Glc/ribitol_DHase. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR19410. ADH_short_C2. 1 hit.
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PRINTS	PR00081. GDHRDH. PR00080. SDRFAMILY.
PROSITE	PS00061. ADH_SHORT. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DHB11_MACFA

Accession

Primary (citable) accession number: Q4JK73

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2005
Last sequence update:	August 2, 2005
Last modified:	November 25, 2008
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)