Unreviewed, UniProtKB/TrEMBL Q4JHT5 (Q4JHT5_HUMAN)

Names and origin

Protein names

Submitted name:
    Suppressor of cytokine signaling 1 EMBL AAY87931.1
Submitted name:
    cDNA FLJ45719 fis, clone FELNG2001953, highly similar to Suppressor of cytokine signaling 1 EMBL BAG54535.1

Gene names

Name:	SOCS1 EMBL AAY87931.1
ORF Names:	hCG_14617 EMBL EAW85163.1

Organism

Homo sapiens (Human) EMBL AAY87931.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	211 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Pathway	Protein modification; protein ubiquitination. Spearmint SPM001496
Sequence similarities	Contains 1 SOCS box domain.

Ontologies

Gene Ontology (GO)
Biological process	JAK-STAT cascade Inferred from electronic annotation. Source: Compara cytokine-mediated signaling pathway Inferred from electronic annotation. Source: Compara fat cell differentiation Inferred from electronic annotation. Source: Compara negative regulation of insulin receptor signaling pathway Inferred from electronic annotation. Source: Compara negative regulation of tyrosine phosphorylation of Stat3 protein Inferred from electronic annotation. Source: Compara organ regeneration Inferred from electronic annotation. Source: Compara response to cytokine stimulus Inferred from electronic annotation. Source: Compara response to drug Inferred from electronic annotation. Source: Compara response to estradiol stimulus Inferred from electronic annotation. Source: Compara response to lipopolysaccharide Inferred from electronic annotation. Source: Compara response to peptide hormone stimulus Inferred from electronic annotation. Source: Compara response to progesterone stimulus Inferred from electronic annotation. Source: Compara
Molecular function	kinase inhibitor activity Inferred from electronic annotation. Source: Compara protein binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q4JHT5-1 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: 7CC983533F78B127	FASTA	211	23,551
	10 20 30 40 50 60 MVAHNQVAAD NAVSTAAEPR RRPEPSSSSS SSPAAPARPR PCPAVPAPAP GDTHFRTFRS 70 80 90 100 110 120 HADYRRITRA SALLDACGFY WGPLSVHGAH ERLRAEPVGT FLVRDSRQRN CFFALSVKMA 130 140 150 160 170 180 SGPTSIRVHF QAGRFHLDGS RESFDCLFEL LEHYVAAPRR MLGAPLRQRR VRPLQELCRQ 190 200 210 RIVATVGREN LARIPLNPVL RDYLSSFPFQ I

References

[1]	Klimecki W., Yu L. Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[2]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[3]	"NEDO human cDNA sequencing project." Kanehori K., Ishibashi T., Chiba Y., Fujimori K., Hiraoka S., Tanai H., Watanabe S., Ishida S., Ono Y., Hotuta T., Watanabe M., Sugiyama T., Irie R., Otsuki T., Sato H., Wakamatsu A., Ishii S., Yamamoto J. , Isono Y., Kawai-Hio Y., Saito K., Nishikawa T., Kimura K., Matsuo K., Nakamura Y., Sekine M., Kikuchi H., Kanda K., Wagatsuma M., Takahashi-Fujii A., Oshima A., Sugiyama A., Kawakami B., Suzuki Y., Sugano S., Nagahari K., Masuho Y., Nagai K., Isogai T. Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Lung EMBL BAG54535.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ086801 Genomic DNA. Translation: AAY87931.1. AK127621 mRNA. Translation: BAG54535.1. CH471112 Genomic DNA. Translation: EAW85163.1.
IPI	IPI00021491.
RefSeq	NP_003736.1.
UniGene	Hs.50640
3D structure databases
SMR	Q4JHT5. Positions 63-211.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4JHT5.
Proteomic databases
PRIDE	Q4JHT5.
Genome annotation databases
Ensembl	ENST00000332029; ENSP00000329418; ENSG00000185338; Homo sapiens. [Genome view]
GeneID	8651.
KEGG	hsa:8651.
Organism-specific databases
CTD	8651.
HGNC	HGNC:19383. SOCS1.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q4JHT5.
OMA	NCFFAIS.
PhylomeDB	Q4JHT5.
Gene expression databases
ArrayExpress	Q4JHT5.
Bgee	Q4JHT5.
Family and domain databases
InterPro	IPR000980. SH2. IPR001496. SOCS_C. [Graphical view]
Gene3D	G3DSA:3.30.505.10. SH2. 1 hit.
Pfam	PF00017. SH2. 1 hit. PF07525. SOCS_box. 1 hit. [Graphical view]
SMART	SM00252. SH2. 1 hit. SM00253. SOCS. 1 hit. [Graphical view]
PROSITE	PS50001. SH2. 1 hit. PS50225. SOCS. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	32445.

Entry information

Entry name

Q4JHT5_HUMAN

Accession

Primary (citable) accession number: Q4JHT5

Entry history

Integrated into UniProtKB/TrEMBL:	August 2, 2005
Last sequence update:	August 2, 2005
Last modified:	February 9, 2010
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.