Suppressor of cytokine signaling 1 - Homo sapiens (Human)

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Unreviewed, UniProtKB/TrEMBL Q4JHT5 (Q4JHT5_HUMAN)

Last modified February 9, 2010. Version 46. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information

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Names and origin

Protein names

Submitted name:
Suppressor of cytokine signaling 1 EMBL AAY87931.1
Submitted name:
cDNA FLJ45719 fis, clone FELNG2001953, highly similar to Suppressor of cytokine signaling 1 EMBL BAG54535.1

Gene names

Name:	SOCS1 EMBL AAY87931.1
ORF Names:	hCG_14617 EMBL EAW85163.1

Organism

Homo sapiens (Human) EMBL AAY87931.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	211 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

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General annotation (Comments)

Pathway	Protein modification; protein ubiquitination. Spearmint SPM001496
Sequence similarities	Contains 1 SOCS box domain.

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Ontologies

Gene Ontology (GO)
Biological process	JAK-STAT cascade Inferred from electronic annotation. Source: Compara cytokine-mediated signaling pathway Inferred from electronic annotation. Source: Compara fat cell differentiation Inferred from electronic annotation. Source: Compara negative regulation of insulin receptor signaling pathway Inferred from electronic annotation. Source: Compara negative regulation of tyrosine phosphorylation of Stat3 protein Inferred from electronic annotation. Source: Compara organ regeneration Inferred from electronic annotation. Source: Compara response to cytokine stimulus Inferred from electronic annotation. Source: Compara response to drug Inferred from electronic annotation. Source: Compara response to estradiol stimulus Inferred from electronic annotation. Source: Compara response to lipopolysaccharide Inferred from electronic annotation. Source: Compara response to peptide hormone stimulus Inferred from electronic annotation. Source: Compara response to progesterone stimulus Inferred from electronic annotation. Source: Compara
Molecular function	kinase inhibitor activity Inferred from electronic annotation. Source: Compara protein binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Gene Ontology (GO)

Biological process

JAK-STAT cascade

Inferred from electronic annotation. Source: Compara

cytokine-mediated signaling pathway

Inferred from electronic annotation. Source: Compara

fat cell differentiation

Inferred from electronic annotation. Source: Compara

negative regulation of insulin receptor signaling pathway

Inferred from electronic annotation. Source: Compara

negative regulation of tyrosine phosphorylation of Stat3 protein

Inferred from electronic annotation. Source: Compara

organ regeneration

Inferred from electronic annotation. Source: Compara

response to cytokine stimulus

Inferred from electronic annotation. Source: Compara

response to drug

Inferred from electronic annotation. Source: Compara

response to estradiol stimulus

Inferred from electronic annotation. Source: Compara

response to lipopolysaccharide

Inferred from electronic annotation. Source: Compara

response to peptide hormone stimulus

Inferred from electronic annotation. Source: Compara

response to progesterone stimulus

Inferred from electronic annotation. Source: Compara

Molecular function

kinase inhibitor activity

Inferred from electronic annotation. Source: Compara

protein binding

Inferred from electronic annotation. Source: Compara

Complete GO annotation...

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Sequences

Sequence

Length

Mass (Da)

Tools

Q4JHT5-1 [UniParc].

Last modified August 2, 2005. Version 1.
Checksum: 7CC983533F78B127
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FASTA

211

23,551

        10         20         30         40         50         60 
MVAHNQVAAD NAVSTAAEPR RRPEPSSSSS SSPAAPARPR PCPAVPAPAP GDTHFRTFRS 

        70         80         90        100        110        120 
HADYRRITRA SALLDACGFY WGPLSVHGAH ERLRAEPVGT FLVRDSRQRN CFFALSVKMA 

       130        140        150        160        170        180 
SGPTSIRVHF QAGRFHLDGS RESFDCLFEL LEHYVAAPRR MLGAPLRQRR VRPLQELCRQ 

       190        200        210 
RIVATVGREN LARIPLNPVL RDYLSSFPFQ I

« Hide

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References

[1]	Klimecki W., Yu L. Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[2]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[3]	"NEDO human cDNA sequencing project." Kanehori K., Ishibashi T., Chiba Y., Fujimori K., Hiraoka S., Tanai H., Watanabe S., Ishida S., Ono Y., Hotuta T., Watanabe M., Sugiyama T., Irie R., Otsuki T., Sato H., Wakamatsu A., Ishii S., Yamamoto J. Isogai T. Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Lung EMBL BAG54535.1.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ086801 Genomic DNA. Translation: AAY87931.1. AK127621 mRNA. Translation: BAG54535.1. CH471112 Genomic DNA. Translation: EAW85163.1.
IPI	IPI00021491.
RefSeq	NP_003736.1.
UniGene	Hs.50640
3D structure databases
SMR	Q4JHT5. Positions 63-211.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4JHT5.
Proteomic databases
PRIDE	Q4JHT5.
Genome annotation databases
Ensembl	ENST00000332029; ENSP00000329418; ENSG00000185338; Homo sapiens. [Genome view]
GeneID	8651.
KEGG	hsa:8651.
Organism-specific databases
CTD	8651.
HGNC	HGNC:19383. SOCS1.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q4JHT5.
OMA	NCFFAIS.
PhylomeDB	Q4JHT5.
Gene expression databases
ArrayExpress	Q4JHT5.
Bgee	Q4JHT5.
Family and domain databases
InterPro	IPR000980. SH2. IPR001496. SOCS_C. [Graphical view]
Gene3D	G3DSA:3.30.505.10. SH2. 1 hit.
Pfam	PF00017. SH2. 1 hit. PF07525. SOCS_box. 1 hit. [Graphical view]
SMART	SM00252. SH2. 1 hit. SM00253. SOCS. 1 hit. [Graphical view]
PROSITE	PS50001. SH2. 1 hit. PS50225. SOCS. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	32445.

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Entry information

Entry name

Q4JHT5_HUMAN

Accession

Primary (citable) accession number: Q4JHT5

Entry history

Integrated into UniProtKB/TrEMBL:	August 2, 2005
Last sequence update:	August 2, 2005
Last modified:	February 9, 2010
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information