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Protein
Submitted name:

Suppressor of cytokine signaling 1

Gene

SOCS1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.SAAS annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Enzyme and pathway databases

UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Submitted name:
Suppressor of cytokine signaling 1Imported
Submitted name:
cDNA FLJ45719 fis, clone FELNG2001953, highly similar to Suppressor of cytokine signaling 1Imported
Gene namesi
Name:SOCS1Imported
ORF Names:hCG_14617Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000185338.4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134863068

Expressioni

Gene expression databases

BgeeiENSG00000185338
ExpressionAtlasiQ4JHT5 baseline and differential

Structurei

3D structure databases

SMRiQ4JHT5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini79 – 174SH2InterPro annotationAdd BLAST96
Domaini161 – 210SOCS boxInterPro annotationAdd BLAST50

Keywords - Domaini

SH2 domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4566 Eukaryota
ENOG4111V4J LUCA
HOVERGENiHBG002457
KOiK04694
OMAiCGFYWGP
OrthoDBiEOG091G0TJW

Family and domain databases

CDDicd10382 SH2_SOCS1, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR028411 SOCS1
IPR035861 SOCS1_SH2
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
PANTHERiPTHR44621 PTHR44621, 1 hit
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PF07525 SOCS_box, 1 hit
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00253 SOCS, 1 hit
SM00969 SOCS_box, 1 hit
SUPFAMiSSF158235 SSF158235, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit
PS50225 SOCS, 1 hit

Sequencei

Sequence statusi: Complete.

Q4JHT5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAHNQVAAD NAVSTAAEPR RRPEPSSSSS SSPAAPARPR PCPAVPAPAP
60 70 80 90 100
GDTHFRTFRS HADYRRITRA SALLDACGFY WGPLSVHGAH ERLRAEPVGT
110 120 130 140 150
FLVRDSRQRN CFFALSVKMA SGPTSIRVHF QAGRFHLDGS RESFDCLFEL
160 170 180 190 200
LEHYVAAPRR MLGAPLRQRR VRPLQELCRQ RIVATVGREN LARIPLNPVL
210
RDYLSSFPFQ I
Length:211
Mass (Da):23,551
Last modified:August 2, 2005 - v1
Checksum:i7CC983533F78B127
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ086801 Genomic DNA Translation: AAY87931.1
AK127621 mRNA Translation: BAG54535.1
CH471112 Genomic DNA Translation: EAW85163.1
RefSeqiNP_003736.1, NM_003745.1
UniGeneiHs.50640

Genome annotation databases

GeneIDi8651
KEGGihsa:8651
UCSCiuc002dar.2 human

Similar proteinsi

Entry informationi

Entry nameiQ4JHT5_HUMAN
AccessioniPrimary (citable) accession number: Q4JHT5
Entry historyiIntegrated into UniProtKB/TrEMBL: August 2, 2005
Last sequence update: August 2, 2005
Last modified: April 25, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health