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Protein
Submitted name:

Suppressor of cytokine signaling 1

Gene

SOCS1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.SAAS annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Submitted name:
Suppressor of cytokine signaling 1Imported
Submitted name:
cDNA FLJ45719 fis, clone FELNG2001953, highly similar to Suppressor of cytokine signaling 1Imported
Gene namesi
Name:SOCS1Imported
ORF Names:hCG_14617Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000185338.4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134863068.

Expressioni

Gene expression databases

BgeeiENSG00000185338.
ExpressionAtlasiQ4JHT5. baseline and differential.

Structurei

3D structure databases

SMRiQ4JHT5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini79 – 174SH2InterPro annotationAdd BLAST96
Domaini161 – 210SOCS boxInterPro annotationAdd BLAST50

Keywords - Domaini

SH2 domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4566. Eukaryota.
ENOG4111V4J. LUCA.
HOVERGENiHBG002457.
KOiK04694.
OMAiCGFYWGP.
OrthoDBiEOG091G0TJW.

Family and domain databases

CDDicd10382. SH2_SOCS1. 1 hit.
Gene3Di3.30.505.10. 1 hit.
InterProiView protein in InterPro
IPR000980. SH2.
IPR028411. SOCS1.
IPR035861. SOCS1_SH2.
IPR001496. SOCS_box.
PANTHERiPTHR24369:SF109. PTHR24369:SF109. 1 hit.
PfamiView protein in Pfam
PF00017. SH2. 1 hit.
PF07525. SOCS_box. 1 hit.
SMARTiView protein in SMART
SM00252. SH2. 1 hit.
SM00253. SOCS. 1 hit.
SM00969. SOCS_box. 1 hit.
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiView protein in PROSITE
PS50001. SH2. 1 hit.
PS50225. SOCS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4JHT5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAHNQVAAD NAVSTAAEPR RRPEPSSSSS SSPAAPARPR PCPAVPAPAP
60 70 80 90 100
GDTHFRTFRS HADYRRITRA SALLDACGFY WGPLSVHGAH ERLRAEPVGT
110 120 130 140 150
FLVRDSRQRN CFFALSVKMA SGPTSIRVHF QAGRFHLDGS RESFDCLFEL
160 170 180 190 200
LEHYVAAPRR MLGAPLRQRR VRPLQELCRQ RIVATVGREN LARIPLNPVL
210
RDYLSSFPFQ I
Length:211
Mass (Da):23,551
Last modified:August 2, 2005 - v1
Checksum:i7CC983533F78B127
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ086801 Genomic DNA. Translation: AAY87931.1.
AK127621 mRNA. Translation: BAG54535.1.
CH471112 Genomic DNA. Translation: EAW85163.1.
RefSeqiNP_003736.1. NM_003745.1.
UniGeneiHs.50640.

Genome annotation databases

GeneIDi8651.
KEGGihsa:8651.
UCSCiuc002dar.2. human.

Similar proteinsi

Entry informationi

Entry nameiQ4JHT5_HUMAN
AccessioniPrimary (citable) accession number: Q4JHT5
Entry historyiIntegrated into UniProtKB/TrEMBL: August 2, 2005
Last sequence update: August 2, 2005
Last modified: September 27, 2017
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.