ID   OXLA_NOTSC              Reviewed;         517 AA.
AC   Q4JHE2;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   16-JUN-2009, entry version 32.
DE   RecName: Full=L-amino-acid oxidase;
DE            Short=LAAO;
DE            Short=LAO;
DE            EC=1.4.3.2;
DE   Flags: Precursor;
OS   Notechis scutatus scutatus (Mainland tiger snake) (Common tiger
OS   snake).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Scleroglossa; Serpentes; Colubroidea;
OC   Elapidae; Acanthophiinae; Notechis.
OX   NCBI_TaxID=70142;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=16261251; DOI=10.1007/s00018-005-5384-9;
RA   St Pierre L., Woods R., Earl S.T.H., Masci P.P., Lavin M.F.;
RT   "Identification and analysis of venom gland-specific genes from the
RT   coastal taipan (Oxyuranus scutellatus) and related species.";
RL   Cell. Mol. Life Sci. 62:2679-2693(2005).
CC   -!- FUNCTION: Catalyzes an oxidative deamination of predominantly
CC       hydrophobic and aromatic L-amino acids. Inhibits platelet
CC       aggregation. Has an ability to induce apoptosis and hemorrhage.
CC       Has an antibacterial activity (By similarity).
CC   -!- CATALYTIC ACTIVITY: An L-amino acid + H(2)O + O(2) = a 2-oxo acid
CC       + NH(3) + H(2)O(2).
CC   -!- COFACTOR: FAD (By similarity).
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Secreted (By similarity).
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- PTM: Glycosylated (By similarity).
CC   -!- SIMILARITY: Belongs to the flavin monoamine oxidase family. FIG1
CC       subfamily.
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DR   EMBL; DQ088991; AAY89681.1; -; mRNA.
DR   SMR; Q4JHE2; 23-504.
DR   HOVERGEN; Q4JHE2; -.
DR   BRENDA; 1.4.3.2; 292759.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR   GO; GO:0001716; F:L-amino-acid oxidase activity; IEA:EC.
DR   GO; GO:0006915; P:apoptosis; IEA:UniProtKB-KW.
DR   GO; GO:0007596; P:blood coagulation; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR001613; Amineoxid_fl.
DR   InterPro; IPR002937; Amino_oxidase.
DR   Pfam; PF01593; Amino_oxidase; 1.
DR   PRINTS; PR00757; AMINEOXDASEF.
PE   2: Evidence at transcript level;
KW   Antibiotic; Antimicrobial; Apoptosis; Blood coagulation;
KW   Disulfide bond; FAD; Flavoprotein; Glycoprotein; Oxidoreductase;
KW   Secreted; Signal; Toxin.
FT   SIGNAL        1     18       By similarity.
FT   CHAIN        19    517       L-amino-acid oxidase.
FT                                /FTId=PRO_5000140379.
FT   NP_BIND     108    109       FAD (By similarity).
FT   NP_BIND     485    488       FAD (By similarity).
FT   BINDING      82     82       FAD (By similarity).
FT   BINDING      90     90       FAD (By similarity).
FT   BINDING     109    109       Substrate (By similarity).
FT   BINDING     280    280       FAD; via amide nitrogen and carbonyl
FT                                oxygen (By similarity).
FT   BINDING     391    391       Substrate (By similarity).
FT   BINDING     476    476       FAD (By similarity).
FT   CARBOHYD    191    191       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    380    380       N-linked (GlcNAc...) (Potential).
FT   DISULFID     29    192       By similarity.
FT   DISULFID    350    431       By similarity.
SQ   SEQUENCE   517 AA;  59058 MW;  E5A0DFF675FF34E1 CRC64;
     MNVFFMFSLL FLAALESCAD DRRRPLEECF QEADYEEFLE IARNGLNETS NPKHVVVVGA
     GMAGLSAAYV LAGAGHNVTL LEASERVGGR VNTYRNETEG WYVNLGPMRL PERHRIIREY
     IRKFGLKLNE FLQENENAWY FIRNIRKRVW EVKKDPGVFK YPVEPSEEGK SASQLYRESL
     EKVIEELKRT NCSYILNKYD TYSTKEYLIK EGNLSRGAVD MIGKLPNEDS SYYLSFIESL
     KSDDLFSYEK RFDEIVGGFD QLPISMYQAI AEMVHLNAQV IKIQHNAEEV RVAYQTPAKT
     LSYVTADYVI VCSTSRAARR IYFEPPLPPK KAHALRSIHY RSGTKIFLTC TRKFWEADGI
     HGGKSTTDLP SRFIYYPNHN FTSDVGVIVA YTLADDADFF QALDIKTSAD IVINDLSLIH
     QLPKEEIQAL CYPSMIKKWS LDKYAMGAIT SFTPYQFQDF IETVAAPVGR IYFAGEYTAR
     VHGWLDSTIK SGLTAARDVN RASQKPSRRQ LSNDNEL
//