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Q4JHE2

- OXLA_NOTSC

UniProt

Q4JHE2 - OXLA_NOTSC

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Protein

L-amino-acid oxidase

Gene
N/A
Organism
Notechis scutatus scutatus (Mainland tiger snake) (Common tiger snake)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids, thus producing hydrogen peroxide that may contribute to the diverse toxic effects of this enzyme. Exhibits diverse biological activities, such as hemorrhage, hemolysis, edema, apoptosis of vascular endothelial cells or tumor cell lines, antibacterial and antiparasitic activities, as well as regulation of platelet aggregation. Effects of snake L-amino oxidases on platelets are controversial, since they either induce aggregation or inhibit agonist-induced aggregation. These different effects are probably due to different experimental conditions (By similarity).By similarity

Catalytic activityi

An L-amino acid + H2O + O2 = a 2-oxo acid + NH3 + H2O2.

Cofactori

FAD.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei90 – 901FADBy similarity
Binding sitei109 – 1091SubstrateBy similarity
Binding sitei280 – 2801FAD; via amide nitrogen and carbonyl oxygenBy similarity
Binding sitei391 – 3911SubstrateBy similarity
Binding sitei476 – 4761FADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi62 – 632FADBy similarity
Nucleotide bindingi82 – 832FADBy similarity
Nucleotide bindingi106 – 1094FADBy similarity
Nucleotide bindingi483 – 4886FADBy similarity
Nucleotide bindingi483 – 4842SubstrateBy similarity

GO - Molecular functioni

  1. L-amino-acid oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. defense response to bacterium Source: UniProtKB-KW
  3. hemolysis in other organism Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Hemostasis impairing toxin, Oxidoreductase, Toxin

Keywords - Biological processi

Apoptosis, Cytolysis, Hemolysis

Keywords - Ligandi

FAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
L-amino-acid oxidase (EC:1.4.3.2)
Short name:
LAAO
Short name:
LAO
OrganismiNotechis scutatus scutatus (Mainland tiger snake) (Common tiger snake)
Taxonomic identifieri70142 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaElapidaeAcanthophiinaeNotechis

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818By similarityAdd
BLAST
Chaini19 – 517499L-amino-acid oxidasePRO_5000140379Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi29 ↔ 192By similarity
Glycosylationi191 – 1911N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi350 ↔ 431By similarity
Glycosylationi380 – 3801N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Homodimer; non-covalently linked.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ4JHE2.
SMRiQ4JHE2. Positions 23-505.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG005729.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002937. Amino_oxidase.
IPR001613. Flavin_amine_oxidase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01593. Amino_oxidase. 1 hit.
[Graphical view]
PRINTSiPR00757. AMINEOXDASEF.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4JHE2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNVFFMFSLL FLAALESCAD DRRRPLEECF QEADYEEFLE IARNGLNETS
60 70 80 90 100
NPKHVVVVGA GMAGLSAAYV LAGAGHNVTL LEASERVGGR VNTYRNETEG
110 120 130 140 150
WYVNLGPMRL PERHRIIREY IRKFGLKLNE FLQENENAWY FIRNIRKRVW
160 170 180 190 200
EVKKDPGVFK YPVEPSEEGK SASQLYRESL EKVIEELKRT NCSYILNKYD
210 220 230 240 250
TYSTKEYLIK EGNLSRGAVD MIGKLPNEDS SYYLSFIESL KSDDLFSYEK
260 270 280 290 300
RFDEIVGGFD QLPISMYQAI AEMVHLNAQV IKIQHNAEEV RVAYQTPAKT
310 320 330 340 350
LSYVTADYVI VCSTSRAARR IYFEPPLPPK KAHALRSIHY RSGTKIFLTC
360 370 380 390 400
TRKFWEADGI HGGKSTTDLP SRFIYYPNHN FTSDVGVIVA YTLADDADFF
410 420 430 440 450
QALDIKTSAD IVINDLSLIH QLPKEEIQAL CYPSMIKKWS LDKYAMGAIT
460 470 480 490 500
SFTPYQFQDF IETVAAPVGR IYFAGEYTAR VHGWLDSTIK SGLTAARDVN
510
RASQKPSRRQ LSNDNEL
Length:517
Mass (Da):59,058
Last modified:August 2, 2005 - v1
Checksum:iE5A0DFF675FF34E1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ088991 mRNA. Translation: AAY89681.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ088991 mRNA. Translation: AAY89681.1 .

3D structure databases

ProteinModelPortali Q4JHE2.
SMRi Q4JHE2. Positions 23-505.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG005729.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR002937. Amino_oxidase.
IPR001613. Flavin_amine_oxidase.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF01593. Amino_oxidase. 1 hit.
[Graphical view ]
PRINTSi PR00757. AMINEOXDASEF.
ProtoNeti Search...

Publicationsi

  1. "Identification and analysis of venom gland-specific genes from the coastal taipan (Oxyuranus scutellatus) and related species."
    St Pierre L., Woods R., Earl S.T.H., Masci P.P., Lavin M.F.
    Cell. Mol. Life Sci. 62:2679-2693(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Venom gland.

Entry informationi

Entry nameiOXLA_NOTSC
AccessioniPrimary (citable) accession number: Q4JHE2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: August 2, 2005
Last modified: October 29, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3