SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q4JHE1

- OXLA_PSEAU

UniProt

Q4JHE1 - OXLA_PSEAU

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

L-amino-acid oxidase

Gene
N/A
Organism
Pseudechis australis (Mulga snake) (King brown snake)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids, thus producing hydrogen peroxide that may contribute to the diverse toxic effects of this enzyme. Exhibits diverse biological activities, such as hemorrhage, hemolysis, edema, apoptosis of vascular endothelial cells or tumor cell lines, antiparasitic activities, as well as regulation of platelet aggregation. Effects of snake L-amino oxidases on platelets are controversial, since they either induce aggregation or inhibit agonist-induced aggregation. These different effects are probably due to different experimental conditions By similarity. This protein has antibacterial activities.1 Publication

Catalytic activityi

An L-amino acid + H2O + O2 = a 2-oxo acid + NH3 + H2O2.

Cofactori

FAD By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei90 – 901FAD By similarity
Binding sitei109 – 1091Substrate By similarity
Binding sitei280 – 2801FAD; via amide nitrogen and carbonyl oxygen By similarity
Binding sitei391 – 3911Substrate By similarity
Binding sitei476 – 4761FAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi62 – 632FAD By similarity
Nucleotide bindingi82 – 832FAD By similarity
Nucleotide bindingi106 – 1094FAD By similarity
Nucleotide bindingi483 – 4886FAD By similarity
Nucleotide bindingi483 – 4842Substrate By similarity

GO - Molecular functioni

  1. L-amino-acid oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. defense response to bacterium Source: UniProtKB-KW
  3. hemolysis in other organism Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Hemostasis impairing toxin, Oxidoreductase, Toxin

Keywords - Biological processi

Apoptosis, Cytolysis, Hemolysis

Keywords - Ligandi

FAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
L-amino-acid oxidase (EC:1.4.3.2)
Short name:
LAAO
Short name:
LAO
OrganismiPseudechis australis (Mulga snake) (King brown snake)
Taxonomic identifieri8670 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaElapidaeAcanthophiinaePseudechis

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 By similarityAdd
BLAST
Chaini19 – 517499L-amino-acid oxidasePRO_5000140380Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi29 ↔ 192 By similarity
Glycosylationi191 – 1911N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi350 ↔ 431 By similarity

Post-translational modificationi

N-glycosylated By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Homodimer; non-covalently linked.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ4JHE1.
SMRiQ4JHE1. Positions 23-505.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG005729.

Family and domain databases

InterProiIPR002937. Amino_oxidase.
IPR001613. Flavin_amine_oxidase.
[Graphical view]
PfamiPF01593. Amino_oxidase. 1 hit.
[Graphical view]
PRINTSiPR00757. AMINEOXDASEF.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4JHE1-1 [UniParc]FASTAAdd to Basket

« Hide

MNVFFMFSLL FLAALGSCAD DRRRPLEECF READYEEFLE IAKNGLQRTS    50
NPKRVVVVGA GMAGLSAAYV LAGAGHQVTL LEASERVGGR VNTYRNEKDG 100
WYVNLGPMRL PERHRIIREY IRKFGLELNE FIQENDNAWY FIKNIRKRVS 150
EVKKDPGVFK YPVKPSEEGK SASQLYRESL QKVIEELKRT NCSYILNKYD 200
TYSTKEYLIK EGNLSPGAVD MIGDLLNEDS SYYLSFIESL KSDDIFSYEK 250
RFDEIVGGFD QLPRSMYQAI AEKVHLNAQV IKIQQNAEDV RVTYQTPAKT 300
LSYVIADYVI VCSTSRAARR IHFEPPLPPK KAHALRSIHY RSSTKIFLTC 350
SQKFWEADGI HGGKSTTDLP SRFIYYPNHS FTSGIGVIVA YTLADDTDFF 400
QALDIETSAD IVINDLSLIH QLPKEQIQAL CYPSKIQKWS LDEYAMGAIT 450
SFTPYQFQDF FEIVAAPVGR IYFAGEYTAS VHGWLDSTIK SGLTAARDVN 500
LASQKPSRIQ LSNDNEL 517
Length:517
Mass (Da):58,744
Last modified:August 2, 2005 - v1
Checksum:i9E0ACCD728782BE5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ088992 mRNA. Translation: AAY89682.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ088992 mRNA. Translation: AAY89682.1 .

3D structure databases

ProteinModelPortali Q4JHE1.
SMRi Q4JHE1. Positions 23-505.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG005729.

Family and domain databases

InterProi IPR002937. Amino_oxidase.
IPR001613. Flavin_amine_oxidase.
[Graphical view ]
Pfami PF01593. Amino_oxidase. 1 hit.
[Graphical view ]
PRINTSi PR00757. AMINEOXDASEF.
ProtoNeti Search...

Publicationsi

  1. "Identification and analysis of venom gland-specific genes from the coastal taipan (Oxyuranus scutellatus) and related species."
    St Pierre L., Woods R., Earl S.T.H., Masci P.P., Lavin M.F.
    Cell. Mol. Life Sci. 62:2679-2693(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Venom gland.
  2. "Antibacterial effects of different snake venoms: purification and characterization of antibacterial proteins from Pseudechis australis (Australian king brown or mulga snake) venom."
    Stiles B.G., Sexton F.W., Weinstein S.A.
    Toxicon 29:1129-1141(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT.
    Tissue: Venom.

Entry informationi

Entry nameiOXLA_PSEAU
AccessioniPrimary (citable) accession number: Q4JHE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: August 2, 2005
Last modified: February 19, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi