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Q4JHE1

- OXLA_PSEAU

UniProt

Q4JHE1 - OXLA_PSEAU

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Protein

L-amino-acid oxidase

Gene
N/A
Organism
Pseudechis australis (Mulga snake) (King brown snake)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids, thus producing hydrogen peroxide that may contribute to the diverse toxic effects of this enzyme. Exhibits diverse biological activities, such as hemorrhage, hemolysis, edema, apoptosis of vascular endothelial cells or tumor cell lines, antiparasitic activities, as well as regulation of platelet aggregation. Effects of snake L-amino oxidases on platelets are controversial, since they either induce aggregation or inhibit agonist-induced aggregation. These different effects are probably due to different experimental conditions (By similarity). This protein has antibacterial activities.By similarity1 Publication

Catalytic activityi

An L-amino acid + H2O + O2 = a 2-oxo acid + NH3 + H2O2.

Cofactori

FAD.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei90 – 901FADBy similarity
Binding sitei109 – 1091SubstrateBy similarity
Binding sitei280 – 2801FAD; via amide nitrogen and carbonyl oxygenBy similarity
Binding sitei391 – 3911SubstrateBy similarity
Binding sitei476 – 4761FADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi62 – 632FADBy similarity
Nucleotide bindingi82 – 832FADBy similarity
Nucleotide bindingi106 – 1094FADBy similarity
Nucleotide bindingi483 – 4886FADBy similarity
Nucleotide bindingi483 – 4842SubstrateBy similarity

GO - Molecular functioni

  1. L-amino-acid oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. defense response to bacterium Source: UniProtKB-KW
  3. hemolysis in other organism Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Hemostasis impairing toxin, Oxidoreductase, Toxin

Keywords - Biological processi

Apoptosis, Cytolysis, Hemolysis

Keywords - Ligandi

FAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
L-amino-acid oxidase (EC:1.4.3.2)
Short name:
LAAO
Short name:
LAO
OrganismiPseudechis australis (Mulga snake) (King brown snake)
Taxonomic identifieri8670 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaElapidaeAcanthophiinaePseudechis

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818By similarityAdd
BLAST
Chaini19 – 517499L-amino-acid oxidasePRO_5000140380Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi29 ↔ 192By similarity
Glycosylationi191 – 1911N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi350 ↔ 431By similarity

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Homodimer; non-covalently linked.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ4JHE1.
SMRiQ4JHE1. Positions 23-505.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG005729.

Family and domain databases

InterProiIPR002937. Amino_oxidase.
IPR001613. Flavin_amine_oxidase.
[Graphical view]
PfamiPF01593. Amino_oxidase. 1 hit.
[Graphical view]
PRINTSiPR00757. AMINEOXDASEF.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4JHE1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNVFFMFSLL FLAALGSCAD DRRRPLEECF READYEEFLE IAKNGLQRTS
60 70 80 90 100
NPKRVVVVGA GMAGLSAAYV LAGAGHQVTL LEASERVGGR VNTYRNEKDG
110 120 130 140 150
WYVNLGPMRL PERHRIIREY IRKFGLELNE FIQENDNAWY FIKNIRKRVS
160 170 180 190 200
EVKKDPGVFK YPVKPSEEGK SASQLYRESL QKVIEELKRT NCSYILNKYD
210 220 230 240 250
TYSTKEYLIK EGNLSPGAVD MIGDLLNEDS SYYLSFIESL KSDDIFSYEK
260 270 280 290 300
RFDEIVGGFD QLPRSMYQAI AEKVHLNAQV IKIQQNAEDV RVTYQTPAKT
310 320 330 340 350
LSYVIADYVI VCSTSRAARR IHFEPPLPPK KAHALRSIHY RSSTKIFLTC
360 370 380 390 400
SQKFWEADGI HGGKSTTDLP SRFIYYPNHS FTSGIGVIVA YTLADDTDFF
410 420 430 440 450
QALDIETSAD IVINDLSLIH QLPKEQIQAL CYPSKIQKWS LDEYAMGAIT
460 470 480 490 500
SFTPYQFQDF FEIVAAPVGR IYFAGEYTAS VHGWLDSTIK SGLTAARDVN
510
LASQKPSRIQ LSNDNEL
Length:517
Mass (Da):58,744
Last modified:August 2, 2005 - v1
Checksum:i9E0ACCD728782BE5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ088992 mRNA. Translation: AAY89682.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ088992 mRNA. Translation: AAY89682.1 .

3D structure databases

ProteinModelPortali Q4JHE1.
SMRi Q4JHE1. Positions 23-505.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG005729.

Family and domain databases

InterProi IPR002937. Amino_oxidase.
IPR001613. Flavin_amine_oxidase.
[Graphical view ]
Pfami PF01593. Amino_oxidase. 1 hit.
[Graphical view ]
PRINTSi PR00757. AMINEOXDASEF.
ProtoNeti Search...

Publicationsi

  1. "Identification and analysis of venom gland-specific genes from the coastal taipan (Oxyuranus scutellatus) and related species."
    St Pierre L., Woods R., Earl S.T.H., Masci P.P., Lavin M.F.
    Cell. Mol. Life Sci. 62:2679-2693(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Venom gland.
  2. "Antibacterial effects of different snake venoms: purification and characterization of antibacterial proteins from Pseudechis australis (Australian king brown or mulga snake) venom."
    Stiles B.G., Sexton F.W., Weinstein S.A.
    Toxicon 29:1129-1141(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT.
    Tissue: Venom.

Entry informationi

Entry nameiOXLA_PSEAU
AccessioniPrimary (citable) accession number: Q4JHE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: August 2, 2005
Last modified: October 29, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3