Q4JHD9 (Q4JHD9_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
11B-hydroxysteroid dehydrogenase type 1 EMBL AAY98349.1

Submitted name:
Hydroxysteroid 11-beta dehydrogenase 1 EMBL AAI32365.1

Gene names

Name:

Hsd11b1 EMBL AAI38781.1 MGI 103562

Organism

Mus musculus (Mouse) EMBL AAY98349.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	292 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Gene Ontology (GO)
Biological process	lung development Inferred from mutant phenotype. Source: MGI
Molecular function	11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity Inferred from direct assay. Source: MGI nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q4JHD9 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: ADE42B11D82DD6CD	FASTA	292	32,364
	10 20 30 40 50 60 MAVMKNYLLP ILVLFLAYYY YSTNEEFRPE MLQGKKVIVT GASKGIGREM AYHLSKMGAH 70 80 90 100 110 120 VVLTARSEEG LQKVVSRCLE LGAASAHYIA GTMEDMTFAE QFIVKAGKLM GGLDMLILNH 130 140 150 160 170 180 ITQTSLSLFH DDIHSVRRVM EVNFLSYVVM STAALPMLKQ SNGSIAVISS LAGKMTQPMI 190 200 210 220 230 240 APYSASKFAL DGFFSTIRTE LYITKVNVSI TLCVLGLIDT ETAMKEISGI INAQASPKEE 250 260 270 280 290 CALEIIKGTA LRKSEVYYDK SPLTPILLGN PGRKIMEFFS LRYYNKDMFV SN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Antisense Transcription in the Mammalian Transcriptome." RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium Science 309:1564-1566(2005) [PubMed: 16141073] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE28932.1. Tissue: Liver EMBL BAE28932.1.
[2]	"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer." Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y. Genome Res. 10:1757-1771(2000) [PubMed: 11076861] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE28932.1. Tissue: Liver EMBL BAE28932.1.
[3]	"Differential modulation of 3T3-L1 adipogenesis mediated by 11beta-hydroxysteroid dehydrogenase-1 levels." Kim J., Temple K.A., Jones S.A., Meredith K.N., Basko J.L., Brady M.J. J. Biol. Chem. 282:11038-11046(2007) [PubMed: 17311922] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL AAY98349.1.
[4]	"Functional annotation of a full-length mouse cDNA collection." The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium Nature 409:685-690(2001) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE28932.1. Tissue: Liver EMBL BAE28932.1.
[5]	"High-efficiency full-length cDNA cloning." Carninci P., Hayashizaki Y. Methods Enzymol. 303:19-44(1999) [PubMed: 10349636] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE28932.1. Tissue: Liver EMBL BAE28932.1.
[6]	"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes." Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y. Genome Res. 10:1617-1630(2000) [PubMed: 11042159] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE28932.1. Tissue: Liver EMBL BAE28932.1.
[7]	"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs." The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team Nature 420:563-573(2002) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE28932.1. Tissue: Liver EMBL BAE28932.1.
[8]	"The Transcriptional Landscape of the Mammalian Genome." The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) Science 309:1559-1563(2005) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE28932.1. Tissue: Liver EMBL BAE28932.1.
[9]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung EMBL AAI32365.1.
[10]	Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H. , Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y. Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE28932.1. Tissue: Liver EMBL BAE28932.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC132364 mRNA. Translation: AAI32365.1. BC138780 mRNA. Translation: AAI38781.1. BC145415 mRNA. Translation: AAI45416.1. DQ089001 mRNA. Translation: AAY98349.1. AK149518 mRNA. Translation: BAE28932.1.
IPI	IPI00115599.
RefSeq	NP_001038216.1. NM_001044751.1. NP_032314.2. NM_008288.2.
UniGene	Mm.28328.
3D structure databases
ProteinModelPortal	Q4JHD9.
SMR	Q4JHD9. Positions 25-289.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4JHD9.
Proteomic databases
PRIDE	Q4JHD9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	15483.
KEGG	mmu:15483.
UCSC	uc007eeg.1. mouse.
Organism-specific databases
CTD	3290.
MGI	MGI:103562. Hsd11b1.
Phylogenomic databases
GeneTree	ENSGT00540000069900.
HOVERGEN	HBG005481.
InParanoid	Q4JHD9.
OMA	SSIRKEY.
PhylomeDB	Q4JHD9.
Gene expression databases
ArrayExpress	Q4JHD9.
Bgee	Q4JHD9.
Genevestigator	Q4JHD9.
Family and domain databases
InterPro	IPR002198. DH_sc/Rdtase_SDR. IPR002347. Glc/ribitol_DH. IPR016040. NAD(P)-bd_dom. IPR020904. Sc_DH/Rdtase_CS. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00071.
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PRINTS	PR00081. GDHRDH.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	288336.
SOURCE	Search...

Entry information

Entry name

Q4JHD9_MOUSE

Accession

Primary (citable) accession number: Q4JHD9

Entry history

Integrated into UniProtKB/TrEMBL:	August 2, 2005
Last sequence update:	August 2, 2005
Last modified:	December 14, 2011
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)