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Protein
Submitted name:

Mcl-1 ubiquitin ligase

Gene

Huwe1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.SAAS annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

LigaseImported, TransferaseSAAS annotation

Keywords - Biological processi

Ubl conjugation pathwaySAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Mcl-1 ubiquitin ligaseImported
Gene namesi
Name:Huwe1Imported
Synonyms:MuleImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1926884. Huwe1.

PTM / Processingi

Proteomic databases

PaxDbiQ4JG03.
PeptideAtlasiQ4JG03.
PRIDEiQ4JG03.

Expressioni

Gene expression databases

GenevisibleiQ4JG03. MM.

Interactioni

Protein-protein interaction databases

IntActiQ4JG03. 1 interactor.
STRINGi10090.ENSMUSP00000026292.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1316 – 1355UBAInterPro annotationAdd BLAST40
Domaini1603 – 1680WWEInterPro annotationAdd BLAST78
Domaini4042 – 4378HECT (E6AP-type E3 ubiquitin-protein ligase)InterPro annotationAdd BLAST337

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1402 – 1423Sequence analysisAdd BLAST22
Coiled coili2682 – 2704Sequence analysisAdd BLAST23

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0939. Eukaryota.
COG5021. LUCA.
HOVERGENiHBG080254.
KOiK10592.

Family and domain databases

CDDicd00078. HECTc. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR025527. DUF4414.
IPR010309. E3_Ub_ligase_DUF908.
IPR010314. E3_Ub_ligase_DUF913.
IPR000569. HECT_dom.
IPR015940. UBA.
IPR009060. UBA-like.
IPR004170. WWE-dom.
[Graphical view]
PfamiPF14377. DUF4414. 1 hit.
PF06012. DUF908. 1 hit.
PF06025. DUF913. 1 hit.
PF00632. HECT. 1 hit.
PF00627. UBA. 1 hit.
PF02825. WWE. 1 hit.
[Graphical view]
SMARTiSM00119. HECTc. 1 hit.
SM00165. UBA. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF48371. SSF48371. 3 hits.
SSF56204. SSF56204. 1 hit.
PROSITEiPS50237. HECT. 1 hit.
PS50030. UBA. 1 hit.
PS50918. WWE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4JG03-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVDRTKLKK TPTEAPADCR ALIDKLKVCN DEQLLLELQQ IKTWNIGKCE
60 70 80 90 100
LYHWVDLLDR FDGILADAGQ TVENMSWMLV CDRPEKEQLK MLLLAVLNFT
110 120 130 140 150
ALLIEYSFSR HLYSSIEHLT TLLASSDMQV VLAVLNLLYV FSKRSNYITR
160 170 180 190 200
LGSDKRTPLL TRLQHLAESW GGKENGFGLA ECCRDLQMLK YPPSATTLHF
210 220 230 240 250
EFYADPGAEV KIEKRTTSNT LHYIHIEQLD KISESPSEIM ESLTKMYSIP
260 270 280 290 300
KDRQMLLFTH IRLAHGFSNH RKRLQAVQAR LHAISILVYS NALQESANSI
310 320 330 340 350
LYNGLIEELV DVLQITDKQL MEIKAASLRT LTSIVHLERT PKLSSIIDCT
360 370 380 390 400
GTASYHGFLP VLVRNCIQAM IDPSMDPYPH QFATALFSFL YHLASYDAGG
410 420 430 440 450
EALVSCGMME ALLKVIKFLG DEQDQITFVT RAVRVVDLIT NLDMAAFQSH
460 470 480 490 500
SGLSIFIYRL EHEVDLCRKE CPFVIKPKIQ RPSTTQEGEE METDMDGVQC
510 520 530 540 550
IPQRAALLKS MLNFLKKAIQ DPAFSDGIRH VMDGSLPTSL KHIISNAEYY
560 570 580 590 600
GPSLFLLATE VVTVFVFQEP SLLSSLQDNG LTDVMLHALL IKDVPATREV
610 620 630 640 650
LGSLPNVFSA LCLNARGLQS FVQCQPFERL FKVLLSPDYL PAMRRRRSSD
660 670 680 690 700
PLGDTASNLG SAVDELMRHQ PTLKTDATTA IIKLLEEICN LGRDPKYICQ
710 720 730 740 750
KPSIQKADGT ATAPPPRSNH AAEEASSEDE EEEEVQAMQS FNSAQQNETE
760 770 780 790 800
PNQQVVGTEE RIPIPLMDYI LNVMKFVESI LSNNTTDDHC QEFVNQKGLL
810 820 830 840 850
PLVTILGLPN LPIDFPTSAA CQAVAGVCKS ILTLSHEPKV LQEGLLQLDL
860 870 880 890 900
ILSSLEPLHR PIESPGGSVL LRELACAGNV ADATLSAQAT PLLHALTAAH
910 920 930 940 950
AYIMMFVHTC RVGQSEIRSI SVNQWGSQLG LSVLSKLSQL YCSLVWESTV
960 970 980 990 1000
LLSLCTPNSL PSGCEFGQAD MQKLVPKDEK AGTTQGGKRS DGEQDGTAGS
1010 1020 1030 1040 1050
MDASAQGLLE GIELDGDTLA PMETDEPSSS DSKGKSKITP AMAARIKQIK
1060 1070 1080 1090 1100
PLLSASSRLG RALAELFGLL VKLCVGSPVR QRRSHHAAST TTAPTPAARS
1110 1120 1130 1140 1150
TASALTKLLT KGLSWQPPPY TPTPRFRLTF FICSVGFTSP MLFDERKYPY
1160 1170 1180 1190 1200
HLMLQKFLCS GGHNALFETF NWALSMGGKV PVSEGLEHSD LPDGTGEFLD
1210 1220 1230 1240 1250
AWLMLVEKMV NPTTVLESPH SLPAKLPGGV QSFPQFSALR FLVVTQKAAF
1260 1270 1280 1290 1300
TCIKNLWNRK PLKVYGGRMA ESMLAILCHI LRGEPVIRER LSKEKEGSRG
1310 1320 1330 1340 1350
EEEAGQEEGG SRREPQVNQQ QLQQLMDMGF TREHAMEALL NTSTMEQATE
1360 1370 1380 1390 1400
YLLTHPPPII GGVVRDLSMS EEDQMMRAIA MSLGQDIPMD QRAESPEEVA
1410 1420 1430 1440 1450
CRKEEEERKA REKQEEEEAK CLEKFQDADP LEQDELHTFT DTMLPGCFHL
1460 1470 1480 1490 1500
LDELPDTVYR VCDLIMTAIK RNGADYRDMI LKQVVNQVWE AADVLIKAAL
1510 1520 1530 1540 1550
PLTTSDTKTV SEWISQMATL PQASNLATRI LLLTLLFEEL KLPCAWVVES
1560 1570 1580 1590 1600
SGILNVLIKL LEVVQPCLQA AKEQKEVQTP KWITPVLLLI DFYEKTAISS
1610 1620 1630 1640 1650
KRRAQMTKYL QSNSNNWRWF DDRSGRWCSY SASNNSTIDS AWKSGETSVR
1660 1670 1680 1690 1700
FTAGRRRYTV QFTTMVQVNE ETGNRRPVML TLLRVPRLSK NSKSSNGQEL
1710 1720 1730 1740 1750
EKTLEESKET DIKHKENKGN DIPLALEITN TEKEASLDET KIGEILIQGL
1760 1770 1780 1790 1800
TEDMVTVLIR ACVSMLGVPV DPDTLHATLR LCLRLTRDHK YAMMFAELKS
1810 1820 1830 1840 1850
TRMILNLTQS SGFNGFTPLV TLLLRHIIED PCTLRHTMEK VVRSAATSGA
1860 1870 1880 1890 1900
GSTTSGVVSG SLGSREINYI LRVLGPAACR NPDIFTEVAN CCIRIALPAP
1910 1920 1930 1940 1950
RGSGTASDDE FENLRIKGPN AVQLVKTTPL KPSSLPVIPD TIKEVIYDML
1960 1970 1980 1990 2000
NALAAYHAPE EADKSDPKPG GTTQEVGQLL QDMGDDVYQQ YRSLTRQSSD
2010 2020 2030 2040 2050
FDTQSGFSLN SQVFAADGAP AETSTTGTSQ GEGASTPEET REGKKDKEGD
2060 2070 2080 2090 2100
RTSEEGKQKS KGSKPLMPTS TILRLLAELV RSYVGIATLI ANYSYTVGQS
2110 2120 2130 2140 2150
ELIKEDCSVL AFVLDHLLPH TQNAEDKDTP ALARLFLASL AAAGSGTDAQ
2160 2170 2180 2190 2200
VALVNEVKAA LGRALAMAES TEKHARLQAV MCIISTIMES CPSTSSFYSS
2210 2220 2230 2240 2250
ATAKTQHNGM NNIIRLFLKK GLVNDLARVP HSLDLSSPNM ANTVNAALKP
2260 2270 2280 2290 2300
LETLSRIVNQ PSSLFGSKSA SSKNKSEQDA QGASQDSSSH QQDPGEPGEA
2310 2320 2330 2340 2350
EVQEEDHDVT QTEVADGDIM DGEAETDSVV IAGQPEVLSS QEMQVENELE
2360 2370 2380 2390 2400
DLIDELLERD GGSGNSTIIV SRSGEDESQE DVLMDEAPSN LSQASTLQAN
2410 2420 2430 2440 2450
REDSMNILDP EDEEEHTQEE DSSGSNEDED DSQDEEEEEE EDEEDDQEDD
2460 2470 2480 2490 2500
EGEEGDEDDD DDGSEMELDE DYPDMNASPL VRFERFDRED DLIIEFDNMF
2510 2520 2530 2540 2550
SSATDIPPSP GNIPTTHPLM VRHADHSSLT LGSGSSTTRL TQGIGRSQRT
2560 2570 2580 2590 2600
LRQLTANTGH TIHVHYPGNR QPNPPLILQR LLGPSAAADI LQLSSSLPLQ
2610 2620 2630 2640 2650
SRGRARLLVG NDDVHIIARS DDELLDDFFH DQSTATSQAG TLSSIPTALT
2660 2670 2680 2690 2700
RWTEECKVLD AESMHDCVSV VKVPIVNHLE FLRDEELEER REKRRKQLAE
2710 2720 2730 2740 2750
EETKIIDKGK EDKENRDQSA QCTVTKTNDS TEQNVSDGTP MPDSYPTTPS
2760 2770 2780 2790 2800
STDAPTSESK ETLGTLQPSQ QQPALPPPPS LGEIPQELQS PAEEVANSTQ
2810 2820 2830 2840 2850
LLMPIELEEL GPTRPSGEAE TTQMELSPAP TITSLSPERA EDSDALTAVS
2860 2870 2880 2890 2900
SQLEGSPMDT SSLASCTLEE AVGDTPAAGS SEQPTAGSST PGDAPSVVAE
2910 2920 2930 2940 2950
VQGRPDVSRE SNQPPEDSSP PASSESSSTR DSAVAISGAD SRGILEEPLP
2960 2970 2980 2990 3000
STSSEEEDPL AGISLPEGVD PSFLAALPDD IRREVLQNQL GIRPPTRSAP
3010 3020 3030 3040 3050
SSNSSAPAVV GNPGVTEVSP EFLAALPPAI QEEVLAQQRA EQQRRELAQN
3060 3070 3080 3090 3100
ASSDTPMDPV TFIQTLPSDL RRSVLEDMED SVLAVMPPDI AAEAQALRRE
3110 3120 3130 3140 3150
QEARQRQLMH ERLFGHSSTS ALSAILRSPA FTSRLSGNRG VQYTRLAVQR
3160 3170 3180 3190 3200
GGTFQMGGSS SHNRPSGSNV DTLLRLRGRL LLDHEALSCL LVLLFVDEPK
3210 3220 3230 3240 3250
LNTSRLHRVL RNLCYHAQTR HWVIRSLLSI LQRSSESELC IETPKLSTSE
3260 3270 3280 3290 3300
ERGKKSSKSC ASSSHENRPL DLLHKMESKS SNQLSWLSVS MDAALGCRTN
3310 3320 3330 3340 3350
IFQIQRSGGR KHTEKHASSG STVHIHPQAA PVVCRHVLDT LIQLAKVFPS
3360 3370 3380 3390 3400
HFTQQRTKET NCESDRERGS KQACSPCSSQ SSSSGICTDF WDLLVKLDNM
3410 3420 3430 3440 3450
NVSRKGKNSV KSVPVSSGGE GETSPHSLEA SPLGQLMNML SHPVIRRSSL
3460 3470 3480 3490 3500
LTEKLLRLLS LISIALPENK VSEVQTNSSN SGSSTAATSN TSTTTTTTTT
3510 3520 3530 3540 3550
ATAPTPTPPA ATTPVTSAPA LVAATAISTI TVAASTTVTT PTTATTTVST
3560 3570 3580 3590 3600
STTKGSKSPA KVGEGGSGID FKMVSSGLTE NQLQLSVEVL TSHSCSEEGL
3610 3620 3630 3640 3650
EDAANVLLQL SRGDSGTRDT VLKLLLNGAR HLGYTLCKQI GTLLAELREY
3660 3670 3680 3690 3700
NLEQQRRAQC ETLSPDGLPE EQPQTTKLKG KMQSRFDMAE NVVIVASQKR
3710 3720 3730 3740 3750
PLGGRELQLP SMSMLTSKTS TQKFFLRVLQ VIIQLRDDTR RANKKAKQTG
3760 3770 3780 3790 3800
RLGSSGLGSA SSIQAAVRQL EAEADAIIQM VREGQRARRQ QQAATSESSN
3810 3820 3830 3840 3850
QSETSVRREE SPMDVDQPSP SAQDTQSIVI SDGTPQGEKE KEEKPPELPL
3860 3870 3880 3890 3900
LSEQLSLDEL WDMLGECLKE LEESHDQHAV LVLQPAVEAF FLVHATERES
3910 3920 3930 3940 3950
KPPVRDTRES QLAHIKDEPP PLSPAPLTPA TPSSLDPFFS REPSSMHISS
3960 3970 3980 3990 4000
SLPPDTQKFL RFAETHRTVL NQILRQSTTH LADGPFAVLV DYIRVLDFDV
4010 4020 4030 4040 4050
KRKYFRQELE RLDEGLRKED MAVHVRRDHV FEDSYRELHR KSPEEMKNRL
4060 4070 4080 4090 4100
YIVFEGEEGQ DAGGLLREWY MIISREMFNP MYALFRTSPG DRVTYTINPS
4110 4120 4130 4140 4150
SHCNPNHLSY FKFVGRIVAK AVYDNRLLEC YFTRSFYKHI LGKSVRYTDM
4160 4170 4180 4190 4200
ESEDYHFYQG LVYLLENDVS TLGYDLTFST EVQEFGVCEV RDLKPNGANI
4210 4220 4230 4240 4250
LVTEENKKEY VHLVCQMRMT GAIRKQLAAF LEGFYEIIPK RLISIFTEQE
4260 4270 4280 4290 4300
LELLISGLPT IDIDDLKSNT EYHKYQSNSI QIQWFWRALR SFDQADRAKF
4310 4320 4330 4340 4350
LQFVTGTSKV PLQGFAALEG MNGIQKFQIH RDDRSTDRLP SAHTCFNQLD
4360 4370
LPAYESFEKL RHMLLLAIQE CSEGFGLA
Length:4,378
Mass (Da):482,746
Last modified:August 2, 2005 - v1
Checksum:iA92094AF05B64B63
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ097265 mRNA. Translation: AAY98257.1.
RefSeqiNP_067498.4. NM_021523.4.
UniGeneiMm.27372.
Mm.488413.

Genome annotation databases

GeneIDi59026.
KEGGimmu:59026.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ097265 mRNA. Translation: AAY98257.1.
RefSeqiNP_067498.4. NM_021523.4.
UniGeneiMm.27372.
Mm.488413.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ4JG03. 1 interactor.
STRINGi10090.ENSMUSP00000026292.

Proteomic databases

PaxDbiQ4JG03.
PeptideAtlasiQ4JG03.
PRIDEiQ4JG03.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi59026.
KEGGimmu:59026.

Organism-specific databases

CTDi10075.
MGIiMGI:1926884. Huwe1.

Phylogenomic databases

eggNOGiKOG0939. Eukaryota.
COG5021. LUCA.
HOVERGENiHBG080254.
KOiK10592.

Miscellaneous databases

ChiTaRSiHuwe1. mouse.
SOURCEiSearch...

Gene expression databases

GenevisibleiQ4JG03. MM.

Family and domain databases

CDDicd00078. HECTc. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR025527. DUF4414.
IPR010309. E3_Ub_ligase_DUF908.
IPR010314. E3_Ub_ligase_DUF913.
IPR000569. HECT_dom.
IPR015940. UBA.
IPR009060. UBA-like.
IPR004170. WWE-dom.
[Graphical view]
PfamiPF14377. DUF4414. 1 hit.
PF06012. DUF908. 1 hit.
PF06025. DUF913. 1 hit.
PF00632. HECT. 1 hit.
PF00627. UBA. 1 hit.
PF02825. WWE. 1 hit.
[Graphical view]
SMARTiSM00119. HECTc. 1 hit.
SM00165. UBA. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF48371. SSF48371. 3 hits.
SSF56204. SSF56204. 1 hit.
PROSITEiPS50237. HECT. 1 hit.
PS50030. UBA. 1 hit.
PS50918. WWE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ4JG03_MOUSE
AccessioniPrimary (citable) accession number: Q4JG03
Entry historyi
Integrated into UniProtKB/TrEMBL: August 2, 2005
Last sequence update: August 2, 2005
Last modified: November 30, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.