Q4JDL3 (PTN20_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tyrosine-protein phosphatase non-receptor type 20
Short name=hPTPN20
EC=3.1.3.48

Gene names

Name:	PTPN20A
AND
Name:	PTPN20B

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	420 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Tyrosine-protein phosphatase targeted to sites of actin polymerization in response of varied extracellular stimuli. Has tyrosine phosphatase activity towards various tyrosyl phosphorylated substrates.
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. Ref.1
Subcellular location	Nucleus. Cytoplasm. Cytoplasm › cytoskeleton › centrosome. Note: Colocalizes with the microtubule-organizing center and intracellular membrane compartments. Ref.1
Tissue specificity	Present in many cell lines (at protein level). Widely expressed. Ref.1
Post-translational modification	Phosphorylated upon DNA damage, probably by ATM or ATR.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily. Contains 1 tyrosine-protein phosphatase domain.
Sequence caution	The sequence AAW28797.1 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton Microtubule Nucleus
Coding sequence diversity	Alternative splicing
Molecular function	Hydrolase Protein phosphatase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	peptidyl-tyrosine dephosphorylation Inferred from electronic annotation. Source: GOC
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell microtubule Inferred from electronic annotation. Source: UniProtKB-KW microtubule organizing center Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 15 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q4JDL3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q4JDL3-2)

Also known as: Variant 1;

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: MSSPRDFRAEP → MI

Isoform 3 (identifier: Q4JDL3-3)

Also known as: Variant 10;

The sequence of this isoform differs from the canonical sequence as follows:
     1-43: MSSPRDFRAEPVNDYEGNDSEAEDLNFRETLPSSSQENTPRSK → MGTTCLHLGTLEQSL

Isoform 4 (identifier: Q4JDL3-4)

Also known as: Variant 12;

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: Missing.

Isoform 5 (identifier: Q4JDL3-5)

Also known as: Variant 13;

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: Missing.
     165-306: Missing.

Isoform 6 (identifier: Q4JDL3-6)

Also known as: Variant 3;

The sequence of this isoform differs from the canonical sequence as follows:
     1-192: Missing.
     193-195: LPY → MID

Isoform 7 (identifier: Q4JDL3-7)

Also known as: Variant 7;

The sequence of this isoform differs from the canonical sequence as follows:
     195-226: YDSTRVPLGKSKDYINASYIRIVNCGEEYFYI → FQHHGYSGPNERTTFWHGSNEGAVSLLLRYCA
     227-420: Missing.

Isoform 8 (identifier: Q4JDL3-8)

Also known as: Variant 4;

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: MSSPRDFRAEP → MI
     195-226: YDSTRVPLGKSKDYINASYIRIVNCGEEYFYI → FQHHGYSGPNERTTFWHGSNEGAVSLLLRYCA
     227-420: Missing.

Isoform 9 (identifier: Q4JDL3-9)

Also known as: Variant 18;

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: Missing.
     165-185: ALELKNLPGEFNSGNQPSNRE → MIQHAFLLEKARTTSMLVILE
     186-420: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform 10 (identifier: Q4JDL3-10)

Also known as: Variant 8;

The sequence of this isoform differs from the canonical sequence as follows:
     165-378: Missing.

Isoform 11 (identifier: Q4JDL3-11)

Also known as: Variant 2;

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: MSSPRDFRAEP → MI
     165-306: Missing.

Isoform 12 (identifier: Q4JDL3-12)

Also known as: Variant 11;

The sequence of this isoform differs from the canonical sequence as follows:
     1-43: MSSPRDFRAEPVNDYEGNDSEAEDLNFRETLPSSSQENTPRSK → MGTTCLHLGTLEQSL
     195-226: YDSTRVPLGKSKDYINASYIRIVNCGEEYFYI → FQHHGYSGPNERTTFWHGSNEGAVSLLLRYCA
     227-420: Missing.

Isoform 13 (identifier: Q4JDL3-13)

Also known as: Variant 9;

The sequence of this isoform differs from the canonical sequence as follows:
     114-145: DTRKIVSEGELDQLAQIRPLIFNFHEQTAIKD → VQHHGYSGPNERTTFWHGSNEGAVSLLLRYCA
     146-420: Missing.

Isoform 14 (identifier: Q4JDL3-14)

Also known as: Variant 14;

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: Missing.
     195-226: YDSTRVPLGKSKDYINASYIRIVNCGEEYFYI → FQHHGYSGPNERTTFWHGSNEGAVSLLLRYCA
     227-420: Missing.

Isoform 15 (identifier: Q4JDL3-15)

Also known as: Variant 5;

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: MSSPRDFRAEP → MI
     114-145: DTRKIVSEGELDQLAQIRPLIFNFHEQTAIKD → VQHHGYSGPNERTTFWHGSNEGAVSLLLRYCA
     146-420: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 420	420	Tyrosine-protein phosphatase non-receptor type 20		PRO_0000295755
Regions
	Domain	159 – 412	254	Tyrosine-protein phosphatase
	Region	353 – 359	7	Substrate binding By similarity
Sites
	Active site	353	1	Phosphocysteine intermediate By similarity
	Binding site	323	1	Substrate By similarity
	Binding site	397	1	Substrate By similarity
Natural variations
	Alternative sequence	1 – 192	192	Missing in isoform 6.		VSP_027063
	Alternative sequence	1 – 81	81	Missing in isoform 4, isoform 5, isoform 9 and isoform 14.		VSP_027064
	Alternative sequence	1 – 43	43	MSSPR…TPRSK → MGTTCLHLGTLEQSL in isoform 3 and isoform 12.		VSP_027065
	Alternative sequence	1 – 11	11	MSSPRDFRAEP → MI in isoform 2, isoform 8, isoform 11 and isoform 15.		VSP_027066
	Alternative sequence	114 – 145	32	DTRKI…TAIKD → VQHHGYSGPNERTTFWHGSN EGAVSLLLRYCA in isoform 13 and isoform 15.		VSP_027067
	Alternative sequence	146 – 420	275	Missing in isoform 13 and isoform 15.		VSP_027068
	Alternative sequence	165 – 378	214	Missing in isoform 10.		VSP_027069
	Alternative sequence	165 – 306	142	Missing in isoform 5 and isoform 11.		VSP_027070
	Alternative sequence	165 – 185	21	ALELK…PSNRE → MIQHAFLLEKARTTSMLVIL E in isoform 9.		VSP_038003
	Alternative sequence	186 – 420	235	Missing in isoform 9.		VSP_038004
	Alternative sequence	193 – 195	3	LPY → MID in isoform 6.		VSP_027071
	Alternative sequence	195 – 226	32	YDSTR…EYFYI → FQHHGYSGPNERTTFWHGSN EGAVSLLLRYCA in isoform 7, isoform 8, isoform 12 and isoform 14.		VSP_027072
	Alternative sequence	227 – 420	194	Missing in isoform 7, isoform 8, isoform 12 and isoform 14.		VSP_027073

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: F3A1C8041ACB710E	FASTA	420	48,423
	10 20 30 40 50 60 MSSPRDFRAE PVNDYEGNDS EAEDLNFRET LPSSSQENTP RSKVFENKVN SEKVKLSLRN 70 80 90 100 110 120 FPHNDYEDVF EEPSESGSDP SMWTARGPFR RDRWSSEDEE AAGPSQALSP LLSDTRKIVS 130 140 150 160 170 180 EGELDQLAQI RPLIFNFHEQ TAIKDCLKIL EEKTAAYDIM QEFMALELKN LPGEFNSGNQ 190 200 210 220 230 240 PSNREKNRYR DILPYDSTRV PLGKSKDYIN ASYIRIVNCG EEYFYIATQG PLLSTIDDFW 250 260 270 280 290 300 QMVLENNSNV IAMITREIEG GIIKCYHYWP ISLKKPLELK HFRVFLENYQ ILQYFIIRMF 310 320 330 340 350 360 QVVEKSTGTS HSVKQLQFTK WPDHGTPASA DSFIKYIRYA RKSHLTGPMV VHCSAGIGRT 370 380 390 400 410 420 GVFLCVDVVF CAIVKNCSFN IMDIVAQMRE QRSGMVQTKE QYHFCYDIVL EVLRKLLTLD
	Isoform 2 (Variant 1) [UniParc]. Checksum: 84315BC1463CF896	FASTA	411	47,393
	10 20 30 40 50 60 MIVNDYEGND SEAEDLNFRE TLPSSSQENT PRSKVFENKV NSEKVKLSLR NFPHNDYEDV 70 80 90 100 110 120 FEEPSESGSD PSMWTARGPF RRDRWSSEDE EAAGPSQALS PLLSDTRKIV SEGELDQLAQ 130 140 150 160 170 180 IRPLIFNFHE QTAIKDCLKI LEEKTAAYDI MQEFMALELK NLPGEFNSGN QPSNREKNRY 190 200 210 220 230 240 RDILPYDSTR VPLGKSKDYI NASYIRIVNC GEEYFYIATQ GPLLSTIDDF WQMVLENNSN 250 260 270 280 290 300 VIAMITREIE GGIIKCYHYW PISLKKPLEL KHFRVFLENY QILQYFIIRM FQVVEKSTGT 310 320 330 340 350 360 SHSVKQLQFT KWPDHGTPAS ADSFIKYIRY ARKSHLTGPM VVHCSAGIGR TGVFLCVDVV 370 380 390 400 410 FCAIVKNCSF NIMDIVAQMR EQRSGMVQTK EQYHFCYDIV LEVLRKLLTL D
	Isoform 3 (Variant 10) [UniParc]. Checksum: 0117231EAC24C57B	FASTA	392	45,123
	10 20 30 40 50 60 MGTTCLHLGT LEQSLVFENK VNSEKVKLSL RNFPHNDYED VFEEPSESGS DPSMWTARGP 70 80 90 100 110 120 FRRDRWSSED EEAAGPSQAL SPLLSDTRKI VSEGELDQLA QIRPLIFNFH EQTAIKDCLK 130 140 150 160 170 180 ILEEKTAAYD IMQEFMALEL KNLPGEFNSG NQPSNREKNR YRDILPYDST RVPLGKSKDY 190 200 210 220 230 240 INASYIRIVN CGEEYFYIAT QGPLLSTIDD FWQMVLENNS NVIAMITREI EGGIIKCYHY 250 260 270 280 290 300 WPISLKKPLE LKHFRVFLEN YQILQYFIIR MFQVVEKSTG TSHSVKQLQF TKWPDHGTPA 310 320 330 340 350 360 SADSFIKYIR YARKSHLTGP MVVHCSAGIG RTGVFLCVDV VFCAIVKNCS FNIMDIVAQM 370 380 390 REQRSGMVQT KEQYHFCYDI VLEVLRKLLT LD
	Isoform 4 (Variant 12) [UniParc]. Checksum: 33F1B10881A748C5	FASTA	339	39,184
	10 20 30 40 50 60 MWTARGPFRR DRWSSEDEEA AGPSQALSPL LSDTRKIVSE GELDQLAQIR PLIFNFHEQT 70 80 90 100 110 120 AIKDCLKILE EKTAAYDIMQ EFMALELKNL PGEFNSGNQP SNREKNRYRD ILPYDSTRVP 130 140 150 160 170 180 LGKSKDYINA SYIRIVNCGE EYFYIATQGP LLSTIDDFWQ MVLENNSNVI AMITREIEGG 190 200 210 220 230 240 IIKCYHYWPI SLKKPLELKH FRVFLENYQI LQYFIIRMFQ VVEKSTGTSH SVKQLQFTKW 250 260 270 280 290 300 PDHGTPASAD SFIKYIRYAR KSHLTGPMVV HCSAGIGRTG VFLCVDVVFC AIVKNCSFNI 310 320 330 MDIVAQMREQ RSGMVQTKEQ YHFCYDIVLE VLRKLLTLD
	Isoform 5 (Variant 13) [UniParc]. Checksum: 75CC97D2E52F5EE4	FASTA	197	22,439
	10 20 30 40 50 60 MWTARGPFRR DRWSSEDEEA AGPSQALSPL LSDTRKIVSE GELDQLAQIR PLIFNFHEQT 70 80 90 100 110 120 AIKDCLKILE EKTAAYDIMQ EFMTGTSHSV KQLQFTKWPD HGTPASADSF IKYIRYARKS 130 140 150 160 170 180 HLTGPMVVHC SAGIGRTGVF LCVDVVFCAI VKNCSFNIMD IVAQMREQRS GMVQTKEQYH 190 FCYDIVLEVL RKLLTLD
	Isoform 6 (Variant 3) [UniParc]. Checksum: 7A416A64EF1E9D8C	FASTA	228	26,374
	10 20 30 40 50 60 MIDDSTRVPL GKSKDYINAS YIRIVNCGEE YFYIATQGPL LSTIDDFWQM VLENNSNVIA 70 80 90 100 110 120 MITREIEGGI IKCYHYWPIS LKKPLELKHF RVFLENYQIL QYFIIRMFQV VEKSTGTSHS 130 140 150 160 170 180 VKQLQFTKWP DHGTPASADS FIKYIRYARK SHLTGPMVVH CSAGIGRTGV FLCVDVVFCA 190 200 210 220 IVKNCSFNIM DIVAQMREQR SGMVQTKEQY HFCYDIVLEV LRKLLTLD
	Isoform 7 (Variant 7) [UniParc]. Checksum: 7E024F34E1952E10	FASTA	226	25,881
	10 20 30 40 50 60 MSSPRDFRAE PVNDYEGNDS EAEDLNFRET LPSSSQENTP RSKVFENKVN SEKVKLSLRN 70 80 90 100 110 120 FPHNDYEDVF EEPSESGSDP SMWTARGPFR RDRWSSEDEE AAGPSQALSP LLSDTRKIVS 130 140 150 160 170 180 EGELDQLAQI RPLIFNFHEQ TAIKDCLKIL EEKTAAYDIM QEFMALELKN LPGEFNSGNQ 190 200 210 220 PSNREKNRYR DILPFQHHGY SGPNERTTFW HGSNEGAVSL LLRYCA
	Isoform 8 (Variant 4) [UniParc]. Checksum: C4F0BC493F07E554	FASTA	217	24,851
	10 20 30 40 50 60 MIVNDYEGND SEAEDLNFRE TLPSSSQENT PRSKVFENKV NSEKVKLSLR NFPHNDYEDV 70 80 90 100 110 120 FEEPSESGSD PSMWTARGPF RRDRWSSEDE EAAGPSQALS PLLSDTRKIV SEGELDQLAQ 130 140 150 160 170 180 IRPLIFNFHE QTAIKDCLKI LEEKTAAYDI MQEFMALELK NLPGEFNSGN QPSNREKNRY 190 200 210 RDILPFQHHG YSGPNERTTF WHGSNEGAVS LLLRYCA
	Isoform 9 (Variant 18) [UniParc]. Checksum: DD927F235474DDB6	FASTA	104	11,999
	10 20 30 40 50 60 MWTARGPFRR DRWSSEDEEA AGPSQALSPL LSDTRKIVSE GELDQLAQIR PLIFNFHEQT 70 80 90 100 AIKDCLKILE EKTAAYDIMQ EFMMIQHAFL LEKARTTSML VILE
	Isoform 10 (Variant 8) [UniParc]. Checksum: 3AE7C577FAE313F6	FASTA	206	23,869
	10 20 30 40 50 60 MSSPRDFRAE PVNDYEGNDS EAEDLNFRET LPSSSQENTP RSKVFENKVN SEKVKLSLRN 70 80 90 100 110 120 FPHNDYEDVF EEPSESGSDP SMWTARGPFR RDRWSSEDEE AAGPSQALSP LLSDTRKIVS 130 140 150 160 170 180 EGELDQLAQI RPLIFNFHEQ TAIKDCLKIL EEKTAAYDIM QEFMFNIMDI VAQMREQRSG 190 200 MVQTKEQYHF CYDIVLEVLR KLLTLD
	Isoform 11 (Variant 2) [UniParc]. Checksum: 26C149800AABD0C2	FASTA	269	30,648
	10 20 30 40 50 60 MIVNDYEGND SEAEDLNFRE TLPSSSQENT PRSKVFENKV NSEKVKLSLR NFPHNDYEDV 70 80 90 100 110 120 FEEPSESGSD PSMWTARGPF RRDRWSSEDE EAAGPSQALS PLLSDTRKIV SEGELDQLAQ 130 140 150 160 170 180 IRPLIFNFHE QTAIKDCLKI LEEKTAAYDI MQEFMTGTSH SVKQLQFTKW PDHGTPASAD 190 200 210 220 230 240 SFIKYIRYAR KSHLTGPMVV HCSAGIGRTG VFLCVDVVFC AIVKNCSFNI MDIVAQMREQ 250 260 RSGMVQTKEQ YHFCYDIVLE VLRKLLTLD
	Isoform 12 (Variant 11) [UniParc]. Checksum: 3955399CCEBDEF4E	FASTA	198	22,581
	10 20 30 40 50 60 MGTTCLHLGT LEQSLVFENK VNSEKVKLSL RNFPHNDYED VFEEPSESGS DPSMWTARGP 70 80 90 100 110 120 FRRDRWSSED EEAAGPSQAL SPLLSDTRKI VSEGELDQLA QIRPLIFNFH EQTAIKDCLK 130 140 150 160 170 180 ILEEKTAAYD IMQEFMALEL KNLPGEFNSG NQPSNREKNR YRDILPFQHH GYSGPNERTT 190 FWHGSNEGAV SLLLRYCA
	Isoform 13 (Variant 9) [UniParc]. Checksum: CE6E89C11FA531C9	FASTA	145	16,414
	10 20 30 40 50 60 MSSPRDFRAE PVNDYEGNDS EAEDLNFRET LPSSSQENTP RSKVFENKVN SEKVKLSLRN 70 80 90 100 110 120 FPHNDYEDVF EEPSESGSDP SMWTARGPFR RDRWSSEDEE AAGPSQALSP LLSVQHHGYS 130 140 GPNERTTFWH GSNEGAVSLL LRYCA
	Isoform 14 (Variant 14) [UniParc]. Checksum: D800415BBA550F7D	FASTA	145	16,643
	10 20 30 40 50 60 MWTARGPFRR DRWSSEDEEA AGPSQALSPL LSDTRKIVSE GELDQLAQIR PLIFNFHEQT 70 80 90 100 110 120 AIKDCLKILE EKTAAYDIMQ EFMALELKNL PGEFNSGNQP SNREKNRYRD ILPFQHHGYS 130 140 GPNERTTFWH GSNEGAVSLL LRYCA
	Isoform 15 (Variant 5) [UniParc]. Checksum: A29B5EC8F4DE0E89	FASTA	136	15,384
	10 20 30 40 50 60 MIVNDYEGND SEAEDLNFRE TLPSSSQENT PRSKVFENKV NSEKVKLSLR NFPHNDYEDV 70 80 90 100 110 120 FEEPSESGSD PSMWTARGPF RRDRWSSEDE EAAGPSQALS PLLSVQHHGY SGPNERTTFW 130 HGSNEGAVSL LLRYCA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Protein tyrosine phosphatase hPTPN20a is targeted to sites of actin polymerization." Fodero-Tavoletti M.T., Hardy M.P., Cornell B., Katsis F., Sadek C.M., Mitchell C.A., Kemp B.E., Tiganis T. Biochem. J. 389:343-354(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4; 5; 6; 7; 8; 9; 10; 11; 12; 13; 14 AND 15), ENZYME ACTIVITY, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[2]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7). Tissue: Heart and Lung.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY704141 mRNA. Translation: AAW28780.1. AY704142 mRNA. Translation: AAW28781.1. AY704143 mRNA. Translation: AAW28782.1. AY704144 mRNA. Translation: AAW28783.1. AY704145 mRNA. Translation: AAW28784.1. AY704146 mRNA. Translation: AAW28785.1. AY704147 mRNA. Translation: AAW28786.1. AY704148 mRNA. Translation: AAW28787.1. AY704149 mRNA. Translation: AAW28788.1. AY704150 mRNA. Translation: AAW28789.1. AY704151 mRNA. Translation: AAW28790.1. AY704152 mRNA. Translation: AAW28791.1. AY704153 mRNA. Translation: AAW28792.1. AY704154 mRNA. Translation: AAW28793.1. AY704158 mRNA. Translation: AAW28797.1. Sequence problems. AY753191 mRNA. Translation: AAW88572.1. AL450334, AL672108 Genomic DNA. Translation: CAI15685.1. AL358791, BX005072 Genomic DNA. Translation: CAI14088.1. AL358791, BX005072 Genomic DNA. Translation: CAI14090.1. AL672108, AL450334 Genomic DNA. Translation: CAI12200.1. BX005072, AL358791 Genomic DNA. Translation: CAI23640.1. BX005072, AL358791 Genomic DNA. Translation: CAI23642.1. BC093750 mRNA. Translation: AAH93750.1. BC113473 mRNA. Translation: AAI13474.1. BC143394 mRNA. Translation: AAI43395.1. BC171725 mRNA. Translation: AAI71725.1.
IPI	IPI00181741. IPI00294644. IPI00619950. IPI00619972. IPI00643067. IPI00735238. IPI00735509. IPI00737076. IPI00740604. IPI00741003. IPI00854625. IPI00854661. IPI00854704. IPI00854771. IPI00854794.
RefSeq	NP_001035816.1. NM_001042357.3. NP_001035817.1. NM_001042358.3. NP_001035818.1. NM_001042359.2. NP_001035819.1. NM_001042360.2. NP_001035820.1. NM_001042361.3. NP_001035821.1. NM_001042362.2. NP_001035822.1. NM_001042363.3. NP_001035823.1. NM_001042364.3. NP_001035846.1. NM_001042387.1. NP_001035848.1. NM_001042389.1. NP_001035849.1. NM_001042390.1. NP_001035850.1. NM_001042391.1. NP_001035851.1. NM_001042392.1. NP_001035852.1. NM_001042393.1. NP_001035853.1. NM_001042394.1. NP_001035854.1. NM_001042395.1. NP_001035855.1. NM_001042396.1. NP_056420.3. NM_015605.7.
UniGene	Hs.440733. Hs.499552.
3D structure databases
HSSP	HSSP built from PDB template 2G59 based on UniProtKB Q16827.
ProteinModelPortal	Q4JDL3.
ModBase	Search...
PTM databases
PhosphoSite	Q4JDL3.
Proteomic databases
PaxDb	Q4JDL3.
PRIDE	Q4JDL3.
Protocols and materials databases
DNASU	26095.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000331650; ENSP00000331832; ENSG00000183675. ENST00000374218; ENSP00000363335; ENSG00000204179. ENST00000374233; ENSP00000363350; ENSG00000183675. ENST00000374240; ENSP00000363357; ENSG00000183675. ENST00000374339; ENSP00000363459; ENSG00000204179. ENST00000374346; ENSP00000363466; ENSG00000204179. ENST00000395660; ENSP00000379020; ENSG00000183675. ENST00000395661; ENSP00000379021; ENSG00000183675. ENST00000395662; ENSP00000379022; ENSG00000183675. ENST00000395668; ENSP00000379027; ENSG00000183675. ENST00000395674; ENSP00000379033; ENSG00000183675. ENST00000395721; ENSP00000379071; ENSG00000204179. ENST00000395722; ENSP00000379072; ENSG00000204179. ENST00000395725; ENSP00000379075; ENSG00000204179. ENST00000395727; ENSP00000379077; ENSG00000204179. ENST00000437863; ENSP00000403444; ENSG00000204179. ENST00000502254; ENSP00000421404; ENSG00000204179. ENST00000502266; ENSP00000424728; ENSG00000183675. ENST00000502705; ENSP00000420995; ENSG00000204179. ENST00000503851; ENSP00000427676; ENSG00000204179. ENST00000505814; ENSP00000426355; ENSG00000204179. ENST00000506080; ENSP00000421921; ENSG00000204179. ENST00000507417; ENSP00000425723; ENSG00000183675. ENST00000508602; ENSP00000424491; ENSG00000204179. ENST00000509230; ENSP00000421604; ENSG00000183675. ENST00000509599; ENSP00000425012; ENSG00000204179. ENST00000509631; ENSP00000424344; ENSG00000183675. ENST00000509753; ENSP00000425285; ENSG00000183675. ENST00000509774; ENSP00000425362; ENSG00000204179. ENST00000509900; ENSP00000423819; ENSG00000204179. ENST00000510335; ENSP00000421453; ENSG00000204179. ENST00000510840; ENSP00000423545; ENSG00000183675. ENST00000511387; ENSP00000426298; ENSG00000183675. ENST00000511769; ENSP00000424283; ENSG00000204179. ENST00000512321; ENSP00000427588; ENSG00000183675. ENST00000512924; ENSP00000421999; ENSG00000183675. ENST00000513156; ENSP00000425912; ENSG00000204179. ENST00000513266; ENSP00000422839; ENSG00000204179. ENST00000513933; ENSP00000427171; ENSG00000183675. ENST00000514491; ENSP00000424942; ENSG00000183675. ENST00000514592; ENSP00000423839; ENSG00000183675. ENST00000515532; ENSP00000422953; ENSG00000183675. ENST00000577492; ENSP00000463630; ENSG00000264832. ENST00000578057; ENSP00000462327; ENSG00000264832. ENST00000578533; ENSP00000462801; ENSG00000264832. ENST00000578769; ENSP00000461946; ENSG00000264832. ENST00000579331; ENSP00000462511; ENSG00000264832. ENST00000580111; ENSP00000462277; ENSG00000264832. ENST00000580860; ENSP00000462373; ENSG00000264832. ENST00000581259; ENSP00000462053; ENSG00000264832. ENST00000581350; ENSP00000462400; ENSG00000264832. ENST00000581507; ENSP00000464379; ENSG00000264832. ENST00000582045; ENSP00000463987; ENSG00000264832. ENST00000582312; ENSP00000462983; ENSG00000264832. ENST00000582347; ENSP00000464514; ENSG00000264832. ENST00000583073; ENSP00000463133; ENSG00000264832. ENST00000583297; ENSP00000462849; ENSG00000264832. ENST00000583680; ENSP00000463932; ENSG00000264832. ENST00000583723; ENSP00000464692; ENSG00000264832. ENST00000583736; ENSP00000461975; ENSG00000264832. ENST00000584081; ENSP00000464175; ENSG00000264832. ENST00000584823; ENSP00000463290; ENSG00000264832. ENST00000584849; ENSP00000463765; ENSG00000264832.
GeneID	26095. 653129.
KEGG	hsa:26095. hsa:653129.
UCSC	uc001jcz.1. human. uc001jdb.1. human. uc001jdc.1. human. uc001jdd.1. human. uc001jde.1. human. uc001jdf.1. human. uc001jdh.1. human. uc001jdi.1. human. uc001jdj.1. human. uc001jdm.1. human. uc001jdn.1. human. uc001jdo.1. human. uc009xmx.1. human.
Organism-specific databases
CTD	26095. 653129.
GeneCards	GC10M046550. GC10M048738.
HGNC	HGNC:23422. PTPN20A. HGNC:23423. PTPN20B.
MIM	610630. gene. 610631. gene.
neXtProt	NX_Q4JDL3.
PharmGKB	PA134904835.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5599.
HOVERGEN	HBG095763.
InParanoid	Q4JDL3.
OMA	SFNIMDI.
Gene expression databases
ArrayExpress	Q4JDL3.
Bgee	Q4JDL3.
CleanEx	HS_PTPN20A.
Genevestigator	Q4JDL3.
Family and domain databases
InterPro	IPR000387. Tyr/Dual-sp_Pase. IPR016130. Tyr_Pase_AS. IPR000242. Tyr_Pase_rcpt/non-rcpt. [Graphical view]
Pfam	PF00102. Y_phosphatase. 1 hit. [Graphical view]
PRINTS	PR00700. PRTYPHPHTASE.
SMART	SM00194. PTPc. 1 hit. [Graphical view]
PROSITE	PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50055. TYR_PHOSPHATASE_PTP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	48049.
SOURCE	Search...

Entry information

Entry name

PTN20_HUMAN

Accession

Primary (citable) accession number: Q4JDL3
Secondary accession number(s): A6NNH8 , B7ZKV3, Q4JDG6, Q4JDK1, Q4JDK5, Q4JDK6, Q4JDK8, Q4JDK9, Q4JDL0, Q4JDL1, Q4JDL4, Q4JDL5, Q4JDL6, Q4JDL7, Q4JDL8, Q5RJ33, Q5T1G3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 24, 2007
Last sequence update:	August 2, 2005
Last modified:	May 1, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.