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Protein

Triosephosphate isomerase

Gene

tpiA

Organism
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).UniRule annotation

Catalytic activityi

D-glyceraldehyde 3-phosphate = glycerone phosphate.UniRule annotation

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Pathwayi: glycolysis

This protein is involved in step 1 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Triosephosphate isomerase (tpiA)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei93ElectrophileUniRule annotation1
Active sitei141Proton acceptorUniRule annotation1
Binding sitei146Substrate; via carbonyl oxygenUniRule annotation1
Binding sitei180Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis, Pentose shunt

Enzyme and pathway databases

UniPathwayiUPA00109; UER00189.
UPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Triosephosphate isomeraseUniRule annotation (EC:5.3.1.1UniRule annotation)
Short name:
TIMUniRule annotation
Short name:
TPIUniRule annotation
Alternative name(s):
Triose-phosphate isomeraseUniRule annotation
Gene namesi
Name:tpiAUniRule annotation
Ordered Locus Names:Saci_0117
OrganismiSulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Taxonomic identifieri330779 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001018 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000903451 – 230Triosephosphate isomeraseAdd BLAST230

Proteomic databases

PRIDEiQ4JCD8.

Interactioni

Subunit structurei

Homotetramer; dimer of dimers.UniRule annotation

Protein-protein interaction databases

STRINGi330779.Saci_0117.

Structurei

3D structure databases

ProteinModelPortaliQ4JCD8.
SMRiQ4JCD8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni9 – 11Substrate bindingUniRule annotation3
Regioni201 – 202Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the triosephosphate isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01087. Archaea.
COG0149. LUCA.
HOGENOMiHOG000223030.
KOiK01803.
OMAiIPVYAQH.
OrthoDBiPOG093Z0G5K.

Family and domain databases

CDDicd00311. TIM. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00147_A. TIM_A. 1 hit.
InterProiView protein in InterPro
IPR013785. Aldolase_TIM.
IPR033983. Thiazole_synthase_ThiG.
IPR035990. TIM_sf.
IPR000652. Triosephosphate_isomerase.
IPR022891. Triosephosphate_isomerase_arc.
PANTHERiPTHR21139. PTHR21139. 1 hit.
PfamiView protein in Pfam
PF05690. ThiG. 1 hit.
PF00121. TIM. 1 hit.
SUPFAMiSSF51351. SSF51351. 1 hit.
TIGRFAMsiTIGR00419. tim. 1 hit.
PROSITEiView protein in PROSITE
PS51440. TIM_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4JCD8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPPVILINY KAYENSYGKK SIEITKKIEK VSKEYGTEII VSVPATMIHR
60 70 80 90 100
ISEESELTVF AQHVDSGEQG ARTGAILPEM IKDAGARGSL LNHSERRIRL
110 120 130 140 150
DEMAESLERI RVLNLESVVC VDRYELVLPV ALLRPNAVLI EPPELIGTGI
160 170 180 190 200
PVSKAKPEAI TKAVEEIKKT KDVYLLAGAG ITTGEDVFKA IELGADGIGA
210 220 230
ASAVMKAKEP EKVVEDFVKN AIKAMEKRGE
Length:230
Mass (Da):25,122
Last modified:August 2, 2005 - v1
Checksum:i1D59A11139AE9BEC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000077 Genomic DNA. Translation: AAY79541.1.
RefSeqiWP_011277042.1. NC_007181.1.

Genome annotation databases

EnsemblBacteriaiAAY79541; AAY79541; Saci_0117.
GeneIDi3474370.
KEGGisai:Saci_0117.
PATRICifig|330779.12.peg.109.

Similar proteinsi

Entry informationi

Entry nameiTPIS_SULAC
AccessioniPrimary (citable) accession number: Q4JCD8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: August 2, 2005
Last modified: October 25, 2017
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families