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Reviewed, UniProtKB/Swiss-Prot Q4JCA7 (PGMI_SULAC)

Last modified February 9, 2010. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Bifunctional phosphoglucose/phosphomannose isomerase
Alternative name(s):
    Glucose-6-phosphate isomerase
      Short name=GPI
    EC=5.3.1.9
    Phosphoglucose isomerase
      Short name=PGI
    Mannose-6-phosphate isomerase
    EC=5.3.1.8
    Phosphomannose isomerase
      Short name=PMI
Gene names
Ordered Locus Names: Saci_0151
OrganismSulfolobus acidocaldarius [Complete proteome] [HAMAP]
Taxonomic identifier2285 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus

Protein attributes

Sequence length306 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Catalyzes the isomerization of both glucose 6-phosphate and epimeric mannose 6-phosphate at a similar catalytic efficiency By similarity.

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate.

D-mannose 6-phosphate = D-fructose 6-phosphate.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the PGI/PMI family.

Contains 1 SIS domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 306306Bifunctional phosphoglucose/phosphomannose isomerase
PRO_0000227795

Regions

Domain19 – 153135SIS

Sites

Active site2001Proton acceptor By similarity
Active site2161Proton donor By similarity
Active site2961Proton acceptor Probable

Sequences

Sequence LengthMass (Da)Tools
Q4JCA7-1 [UniParc].

Last modified August 2, 2005. Version 1.
Checksum: 771F0D94933A67A4

FASTA30634,158
        10         20         30         40         50         60 
MSNVYERWKE FYEDAISRDI PGVKTAEKIA YFGIGGSGIP GEVLKLLDLP VEYKLFRSYK 

        70         80         90        100        110        120 
VNVDSKTTVV AVSYSGNTAE TLAGVKRAQE LGVKEIIVIT SGGKLKEIAE SKGYPLLSLP 

       130        140        150        160        170        180 
QGYQTRFIFP YIFTYLVRIL NQSTGSNYRV QDLVDGIQDN FTMLSEVSTR IANRITGKVP 

       190        200        210        220        230        240 
IFYASDLLPI AERFKQEVNE NAKYPAFFSQ LPEANHNEIE LYSSQQGNQF IPIVIPSDKI 

       250        260        270        280        290        300 
DEATASLINA ELIYPPYKSI LKNISGMFLI AGLASVKLAS QLNIKAEELR IIPKIRERTH 


NLLMGG 

« Hide

References

[1]"The genome of Sulfolobus acidocaldarius, a model organism of the Crenarchaeota."
Chen L., Bruegger K., Skovgaard M., Redder P., She Q., Torarinsson E., Greve B., Awayez M., Zibat A., Klenk H.-P., Garrett R.A.
J. Bacteriol. 187:4992-4999(2005) [PubMed: 15995215] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 33909 / DSM 639 / IFO 15157 / JCM 8929 / NCIB 11770.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000077 Genomic DNA. Translation: AAY79572.1.
RefSeqYP_254865.1.

3D structure databases

SMRQ4JCA7. Positions 1-299.
ModBaseSearch...

Genome annotation databases

GeneID3474403.
GenomeReviewsGene locus Saci_0151 in contig CP000077_GR.
KEGGsai:Saci_0151.
NMPDRfig|330779.3.peg.254.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG553399.
OMAHNEIELY.

Enzyme and pathway databases

BioCycSACI330779:SACI_0151-MONOMER.
BRENDA5.3.1.8. 434.
5.3.1.9. 434.

Family and domain databases

InterProIPR011857. Glu6P/Mann6P_isomerase.
IPR019490. Glu6P/Mann6P_isomerase_C.
IPR001347. SIS.
[Graphical view]
PfamPF10432. bact-PGI_C. 1 hit.
PF01380. SIS. 1 hit.
[Graphical view]
TIGRFAMsTIGR02128. G6PI_arch. 1 hit.
PROSITEPS51464. SIS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGMI_SULAC
AccessionPrimary (citable) accession number: Q4JCA7
Entry history
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: August 2, 2005
Last modified: February 9, 2010
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents