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Q4JCA7

- PGMI_SULAC

UniProt

Q4JCA7 - PGMI_SULAC

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Protein
Bifunctional phosphoglucose/phosphomannose isomerase
Gene
Saci_0151
Organism
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the isomerization of both glucose 6-phosphate and epimeric mannose 6-phosphate at a similar catalytic efficiency By similarity.

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.
D-mannose 6-phosphate = D-fructose 6-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei200 – 2001Proton acceptor By similarity
Active sitei216 – 2161Proton donor By similarity
Active sitei296 – 2961Proton acceptor Inferred

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glucose-6-phosphate isomerase activity Source: UniProtKB-EC
  3. mannose-6-phosphate isomerase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

BioCyciSACI330779:GH9J-150-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional phosphoglucose/phosphomannose isomerase
Alternative name(s):
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Mannose-6-phosphate isomerase (EC:5.3.1.8)
Phosphoglucose isomerase
Short name:
PGI
Phosphomannose isomerase
Short name:
PMI
Gene namesi
Ordered Locus Names:Saci_0151
OrganismiSulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Taxonomic identifieri330779 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000001018: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 306306Bifunctional phosphoglucose/phosphomannose isomerase
PRO_0000227795Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi330779.Saci_0151.

Structurei

3D structure databases

ProteinModelPortaliQ4JCA7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 153135SIS
Add
BLAST

Sequence similaritiesi

Belongs to the PGI/PMI family.
Contains 1 SIS domain.

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000270998.
KOiK15916.
OMAiILATHTP.

Family and domain databases

InterProiIPR011857. Glu6P/Mann6P_isomerase.
IPR019490. Glu6P/Mann6P_isomerase_C.
IPR001347. SIS.
[Graphical view]
PfamiPF10432. bact-PGI_C. 1 hit.
PF01380. SIS. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02128. G6PI_arch. 1 hit.
PROSITEiPS51464. SIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4JCA7-1 [UniParc]FASTAAdd to Basket

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MSNVYERWKE FYEDAISRDI PGVKTAEKIA YFGIGGSGIP GEVLKLLDLP    50
VEYKLFRSYK VNVDSKTTVV AVSYSGNTAE TLAGVKRAQE LGVKEIIVIT 100
SGGKLKEIAE SKGYPLLSLP QGYQTRFIFP YIFTYLVRIL NQSTGSNYRV 150
QDLVDGIQDN FTMLSEVSTR IANRITGKVP IFYASDLLPI AERFKQEVNE 200
NAKYPAFFSQ LPEANHNEIE LYSSQQGNQF IPIVIPSDKI DEATASLINA 250
ELIYPPYKSI LKNISGMFLI AGLASVKLAS QLNIKAEELR IIPKIRERTH 300
NLLMGG 306
Length:306
Mass (Da):34,158
Last modified:August 2, 2005 - v1
Checksum:i771F0D94933A67A4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000077 Genomic DNA. Translation: AAY79572.1.
RefSeqiYP_254865.1. NC_007181.1.

Genome annotation databases

EnsemblBacteriaiAAY79572; AAY79572; Saci_0151.
GeneIDi3474403.
KEGGisai:Saci_0151.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000077 Genomic DNA. Translation: AAY79572.1 .
RefSeqi YP_254865.1. NC_007181.1.

3D structure databases

ProteinModelPortali Q4JCA7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 330779.Saci_0151.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY79572 ; AAY79572 ; Saci_0151 .
GeneIDi 3474403.
KEGGi sai:Saci_0151.

Phylogenomic databases

eggNOGi COG0166.
HOGENOMi HOG000270998.
KOi K15916.
OMAi ILATHTP.

Enzyme and pathway databases

BioCyci SACI330779:GH9J-150-MONOMER.

Family and domain databases

InterProi IPR011857. Glu6P/Mann6P_isomerase.
IPR019490. Glu6P/Mann6P_isomerase_C.
IPR001347. SIS.
[Graphical view ]
Pfami PF10432. bact-PGI_C. 1 hit.
PF01380. SIS. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02128. G6PI_arch. 1 hit.
PROSITEi PS51464. SIS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of Sulfolobus acidocaldarius, a model organism of the Crenarchaeota."
    Chen L., Bruegger K., Skovgaard M., Redder P., She Q., Torarinsson E., Greve B., Awayez M., Zibat A., Klenk H.-P., Garrett R.A.
    J. Bacteriol. 187:4992-4999(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770.

Entry informationi

Entry nameiPGMI_SULAC
AccessioniPrimary (citable) accession number: Q4JCA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: August 2, 2005
Last modified: May 14, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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