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Q4JCA7

- PGMI_SULAC

UniProt

Q4JCA7 - PGMI_SULAC

Protein

Bifunctional phosphoglucose/phosphomannose isomerase

Gene

Saci_0151

Organism
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (02 Aug 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the isomerization of both glucose 6-phosphate and epimeric mannose 6-phosphate at a similar catalytic efficiency.By similarity

    Catalytic activityi

    D-glucose 6-phosphate = D-fructose 6-phosphate.
    D-mannose 6-phosphate = D-fructose 6-phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei200 – 2001Proton acceptorBy similarity
    Active sitei216 – 2161Proton donorBy similarity
    Active sitei296 – 2961Proton acceptorCurated

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. glucose-6-phosphate isomerase activity Source: UniProtKB-EC
    3. mannose-6-phosphate isomerase activity Source: UniProtKB-EC

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro

    Keywords - Molecular functioni

    Isomerase

    Enzyme and pathway databases

    BioCyciSACI330779:GH9J-150-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional phosphoglucose/phosphomannose isomerase
    Alternative name(s):
    Glucose-6-phosphate isomerase (EC:5.3.1.9)
    Short name:
    GPI
    Mannose-6-phosphate isomerase (EC:5.3.1.8)
    Phosphoglucose isomerase
    Short name:
    PGI
    Phosphomannose isomerase
    Short name:
    PMI
    Gene namesi
    Ordered Locus Names:Saci_0151
    OrganismiSulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
    Taxonomic identifieri330779 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
    ProteomesiUP000001018: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 306306Bifunctional phosphoglucose/phosphomannose isomerasePRO_0000227795Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi330779.Saci_0151.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4JCA7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini19 – 153135SISPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PGI/PMI family.Curated
    Contains 1 SIS domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0166.
    HOGENOMiHOG000270998.
    KOiK15916.
    OMAiILATHTP.

    Family and domain databases

    InterProiIPR011857. Glu6P/Mann6P_isomerase.
    IPR019490. Glu6P/Mann6P_isomerase_C.
    IPR001347. SIS.
    [Graphical view]
    PfamiPF10432. bact-PGI_C. 1 hit.
    PF01380. SIS. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR02128. G6PI_arch. 1 hit.
    PROSITEiPS51464. SIS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4JCA7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNVYERWKE FYEDAISRDI PGVKTAEKIA YFGIGGSGIP GEVLKLLDLP    50
    VEYKLFRSYK VNVDSKTTVV AVSYSGNTAE TLAGVKRAQE LGVKEIIVIT 100
    SGGKLKEIAE SKGYPLLSLP QGYQTRFIFP YIFTYLVRIL NQSTGSNYRV 150
    QDLVDGIQDN FTMLSEVSTR IANRITGKVP IFYASDLLPI AERFKQEVNE 200
    NAKYPAFFSQ LPEANHNEIE LYSSQQGNQF IPIVIPSDKI DEATASLINA 250
    ELIYPPYKSI LKNISGMFLI AGLASVKLAS QLNIKAEELR IIPKIRERTH 300
    NLLMGG 306
    Length:306
    Mass (Da):34,158
    Last modified:August 2, 2005 - v1
    Checksum:i771F0D94933A67A4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000077 Genomic DNA. Translation: AAY79572.1.
    RefSeqiYP_254865.1. NC_007181.1.

    Genome annotation databases

    EnsemblBacteriaiAAY79572; AAY79572; Saci_0151.
    GeneIDi3474403.
    KEGGisai:Saci_0151.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000077 Genomic DNA. Translation: AAY79572.1 .
    RefSeqi YP_254865.1. NC_007181.1.

    3D structure databases

    ProteinModelPortali Q4JCA7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 330779.Saci_0151.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAY79572 ; AAY79572 ; Saci_0151 .
    GeneIDi 3474403.
    KEGGi sai:Saci_0151.

    Phylogenomic databases

    eggNOGi COG0166.
    HOGENOMi HOG000270998.
    KOi K15916.
    OMAi ILATHTP.

    Enzyme and pathway databases

    BioCyci SACI330779:GH9J-150-MONOMER.

    Family and domain databases

    InterProi IPR011857. Glu6P/Mann6P_isomerase.
    IPR019490. Glu6P/Mann6P_isomerase_C.
    IPR001347. SIS.
    [Graphical view ]
    Pfami PF10432. bact-PGI_C. 1 hit.
    PF01380. SIS. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR02128. G6PI_arch. 1 hit.
    PROSITEi PS51464. SIS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of Sulfolobus acidocaldarius, a model organism of the Crenarchaeota."
      Chen L., Bruegger K., Skovgaard M., Redder P., She Q., Torarinsson E., Greve B., Awayez M., Zibat A., Klenk H.-P., Garrett R.A.
      J. Bacteriol. 187:4992-4999(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770.

    Entry informationi

    Entry nameiPGMI_SULAC
    AccessioniPrimary (citable) accession number: Q4JCA7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 21, 2006
    Last sequence update: August 2, 2005
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3