Q4JCA7 (PGMI_SULAC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Bifunctional phosphoglucose/phosphomannose isomerase

Alternative name(s):
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9
Mannose-6-phosphate isomerase
EC=5.3.1.8
Phosphoglucose isomerase
Short name=PGI
Phosphomannose isomerase
Short name=PMI

Gene names

Ordered Locus Names:

Saci_0151

Organism

Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) [Complete proteome] [HAMAP]

Taxonomic identifier

330779 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus › Sulfolobus acidocaldarius

Protein attributes

Sequence length	306 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the isomerization of both glucose 6-phosphate and epimeric mannose 6-phosphate at a similar catalytic efficiency By similarity.
Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. D-mannose 6-phosphate = D-fructose 6-phosphate.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the PGI/PMI family. Contains 1 SIS domain.

Ontologies

Keywords
Molecular function	Isomerase
Technical term	Complete proteome Multifunctional enzyme
Gene Ontology (GO)
Biological_process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	carbohydrate binding Inferred from electronic annotation. Source: InterPro glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC mannose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 306	306	Bifunctional phosphoglucose/phosphomannose isomerase		PRO_0000227795
Regions
	Domain	19 – 153	135	SIS
Sites
	Active site	200	1	Proton acceptor By similarity
	Active site	216	1	Proton donor By similarity
	Active site	296	1	Proton acceptor Probable

Sequences

	Sequence		Length	Mass (Da)
	Q4JCA7 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: 771F0D94933A67A4	FASTA	306	34,158
	10 20 30 40 50 60 MSNVYERWKE FYEDAISRDI PGVKTAEKIA YFGIGGSGIP GEVLKLLDLP VEYKLFRSYK 70 80 90 100 110 120 VNVDSKTTVV AVSYSGNTAE TLAGVKRAQE LGVKEIIVIT SGGKLKEIAE SKGYPLLSLP 130 140 150 160 170 180 QGYQTRFIFP YIFTYLVRIL NQSTGSNYRV QDLVDGIQDN FTMLSEVSTR IANRITGKVP 190 200 210 220 230 240 IFYASDLLPI AERFKQEVNE NAKYPAFFSQ LPEANHNEIE LYSSQQGNQF IPIVIPSDKI 250 260 270 280 290 300 DEATASLINA ELIYPPYKSI LKNISGMFLI AGLASVKLAS QLNIKAEELR IIPKIRERTH NLLMGG

References

[1]

"The genome of Sulfolobus acidocaldarius, a model organism of the Crenarchaeota." Chen L., Bruegger K., Skovgaard M., Redder P., She Q., Torarinsson E., Greve B., Awayez M., Zibat A., Klenk H.-P., Garrett R.A. J. Bacteriol. 187:4992-4999(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000077 Genomic DNA. Translation: AAY79572.1.
RefSeq	YP_254865.1. NC_007181.1.
3D structure databases
ProteinModelPortal	Q4JCA7.
ModBase	Search...
Protein-protein interaction databases
STRING	330779.Saci_0151.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAY79572; AAY79572; Saci_0151.
GeneID	3474403.
KEGG	sai:Saci_0151.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0166.
HOGENOM	HOG000270998.
KO	K15916.
OMA	NAKYPAF.
ProtClustDB	PRK08674.
Enzyme and pathway databases
BioCyc	SACI330779:GH9J-150-MONOMER.
Family and domain databases
InterPro	IPR011857. Glu6P/Mann6P_isomerase. IPR019490. Glu6P/Mann6P_isomerase_C. IPR001347. SIS. [Graphical view]
Pfam	PF10432. bact-PGI_C. 1 hit. PF01380. SIS. 1 hit. [Graphical view]
TIGRFAMs	TIGR02128. G6PI_arch. 1 hit.
PROSITE	PS51464. SIS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGMI_SULAC

Accession

Primary (citable) accession number: Q4JCA7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	August 2, 2005
Last modified:	May 29, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program