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Q4JC68 (XPD_SULAC) Reviewed, UniProtKB/Swiss-Prot

Last modified August 10, 2010. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
Customize displayNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Names and origin

Protein namesRecommended name:
ATP-dependent DNA helicase Saci_0192
EC=3.6.4.12
Gene names
Ordered Locus Names:Saci_0192
OrganismSulfolobus acidocaldarius [Complete proteome] [HAMAP]
Taxonomic identifier2285 [NCBI]
Taxonomic lineageArchaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus

Protein attributes

Sequence length551 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

General annotation (Comments)

Catalytic activity

ATP + H2O = ADP + phosphate.

Sequence similarities

Belongs to the helicase family. RAD3/XPD subfamily.

Contains 1 helicase ATP-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 551551ATP-dependent DNA helicase Saci_0192
PRO_0000352309

Regions

Domain1 – 228228Helicase ATP-binding
Nucleotide binding29 – 368ATP By similarity
Motif180 – 1834DEAH box

Sites

Metal binding881Iron-sulfur (4Fe-4S)
Metal binding1021Iron-sulfur (4Fe-4S)
Metal binding1051Iron-sulfur (4Fe-4S)
Metal binding1371Iron-sulfur (4Fe-4S)

Secondary structure

1 ......................................................................................... 551
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q4JC68-1 [UniParc].

Last modified August 2, 2005. Version 1.
Checksum: BEE17759C4E065DA

FASTA55164,011
        10         20         30         40         50         60 
MLKLRDWQEK LKDKVIEGLR NNFLVALNAP TGSGKTLFSL LVSLEVKPKV LFVVRTHNEF 

        70         80         90        100        110        120 
YPIYRDLTKI REKRNITFSF LVGKPSSCLY AEKGAESEDI PCKYCELKGS IVEVKTDDSP 

       130        140        150        160        170        180 
LSLVKKLKKD GLQDKFCPYY SLLNSLYKAD VIALTYPYFF IDRYREFIDI DLREYMIVID 

       190        200        210        220        230        240 
EAHNLDKVNE LEERSLSEIT IQMAIKQSKS EESRRILSKL LNQLREVVLP DEKYIKVENV 

       250        260        270        280        290        300 
PKLSKEELEI LADDYEDIRK DSLKQGKVNK IHIGSILRFF SLLSIGSFIP FSYSKRLVIK 

       310        320        330        340        350        360 
NPEISYYLNL LNDNELSIIL MSGTLPPREY MEKVWGIKRN MLYLDVEREI QKRVSGSYEC 

       370        380        390        400        410        420 
YIGVDVTSKY DMRSDNMWKR YADYLLKIYF QAKANVLVVF PSYEIMDRVM SRISLPKYVE 

       430        440        450        460        470        480 
SEDSSVEDLY SAISANNKVL IGSVGKGKLA EGIELRNNDR SLISDVVIVG IPYPPPDDYL 

       490        500        510        520        530        540 
KILAQRVSLK MNRENEEFLF KIPALVTIKQ AIGRAIRDVN DKCNVWLLDK RFESLYWKKN 

       550 
LKCLNANKMK L

« Hide

References

« Hide 'large scale' references
[1]"The genome of Sulfolobus acidocaldarius, a model organism of the Crenarchaeota."
Chen L., Bruegger K., Skovgaard M., Redder P., She Q., Torarinsson E., Greve B., Awayez M., Zibat A., Klenk H.-P., Garrett R.A.
J. Bacteriol. 187:4992-4999(2005) [PubMed: 15995215] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 33909 / DSM 639 / IFO 15157 / JCM 8929 / NCIB 11770.
[2]"XPD helicase structures and activities: insights into the cancer and aging phenotypes from XPD mutations."
Fan L., Fuss J.O., Cheng Q.J., Arvai A.S., Hammel M., Roberts V.A., Cooper P.K., Tainer J.A.
Cell 133:789-800(2008) [PubMed: 18510924] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS), IRON-SULFUR CLUSTER.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000077 Genomic DNA. Translation: AAY79611.1.
RefSeqYP_254904.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3CRVX-ray2.00A3-551[»]
3CRWX-ray4.0013-551[»]
ProteinModelPortalQ4JC68.
ModBaseSearch...

Genome annotation databases

GeneID3474005.
GenomeReviewsGene locus Saci_0192 in contig CP000077_GR.
KEGGsai:Saci_0192.
NMPDRfig|330779.3.peg.579.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG553405.
OMACPYEYAK.
ProtClustDBCLSK802665.

Enzyme and pathway databases

BioCycSACI330779:SACI_0192-MONOMER.

Family and domain databases

InterProIPR010614. DEAD_2.
IPR014013. Helic_SF1/SF2_ATP-bd_DinG/Rad3.
IPR006555. Helicase_ATP-dep_c2.
[Graphical view]
PfamPF06733. DEAD_2. 1 hit.
[Graphical view]
SMARTSM00491. HELICc2. 1 hit.
[Graphical view]
PROSITEPS51193. HELICASE_ATP_BIND_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameXPD_SULAC
AccessionPrimary (citable) accession number: Q4JC68
Entry history
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: August 2, 2005
Last modified: August 10, 2010
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents