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Protein

7-cyano-7-deazaguanine synthase

Gene

queC

Organism
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ0).By similarity

Catalytic activityi

7-carboxy-7-carbaguanine + NH3 + ATP = 7-cyano-7-carbaguanine + ADP + phosphate + H2O.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Pathwayi: 7-cyano-7-deazaguanine biosynthesis

This protein is involved in the pathway 7-cyano-7-deazaguanine biosynthesis, which is part of Purine metabolism.
View all proteins of this organism that are known to be involved in the pathway 7-cyano-7-deazaguanine biosynthesis and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2For GATase activityBy similarity1
Metal bindingi428ZincBy similarity1
Metal bindingi436ZincBy similarity1
Metal bindingi439ZincBy similarity1
Metal bindingi442ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi246 – 256ATPBy similarityAdd BLAST11

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00391.

Names & Taxonomyi

Protein namesi
Recommended name:
7-cyano-7-deazaguanine synthase (EC:6.3.4.20)
Alternative name(s):
7-cyano-7-carbaguanine synthase
Archaeosine biosynthesis protein QueC
PreQ(0) synthase
Gene namesi
Name:queC
Ordered Locus Names:Saci_0280
OrganismiSulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Taxonomic identifieri330779 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001018 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002469892 – 4627-cyano-7-deazaguanine synthaseAdd BLAST461

Interactioni

Protein-protein interaction databases

STRINGi330779.Saci_0280.

Structurei

3D structure databases

ProteinModelPortaliQ4JBY3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 225Glutamine amidotransferase type-2Add BLAST224

Sequence similaritiesi

Belongs to the QueC family.Curated

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

eggNOGiarCOG00039. Archaea.
COG0449. LUCA.
COG0603. LUCA.
HOGENOMiHOG000270539.
KOiK06920.
OMAiNEMEFVR.

Family and domain databases

CDDicd01995. ExsB. 1 hit.
Gene3Di3.40.50.620. 1 hit.
3.60.20.10. 1 hit.
HAMAPiMF_01633. QueC. 1 hit.
InterProiIPR017932. GATase_2_dom.
IPR029055. Ntn_hydrolases_N.
IPR018317. QueC.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF13537. GATase_7. 1 hit.
PF06508. QueC. 1 hit.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR00364. TIGR00364. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4JBY3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCSVTGVLIL NPHNYKEIEK KLAKILIRAE DRGRDSFGIV VIQKDGSTKS
60 70 80 90 100
SKHVGKPSLQ EEKLYGILDE NSKVVIANNR AEPTTEYVRR KTENDIQPFE
110 120 130 140 150
GERFVVTHNG IIANDMELEK KYKVSKLSRI DSSVLPPVLD RSWNGNLDSL
160 170 180 190 200
SEILNSIRGS FALVIGDKKN PDRIFIAQNF KPVYMMYDRD LGAVFFTSLD
210 220 230 240 250
DYFDATELDN VTKLDPYSVV MVDDKLEIRK VPLLKEKNKK RILVVASGGL
260 270 280 290 300
DSTVAATYLV RQGHEVTLLH FNYHHKAEEK EREAVRKISE YLNVPFVEID
310 320 330 340 350
TDLFKIVGHS TLIKGSSGEI VKDRKGEEGA EFAHEWVPAR NLIFFSVALA
360 370 380 390 400
MAEAYGFDAI ASGINLEEAG AYPDNEMEFV RMFSRLVPYA VGPNKKVEVL
410 420 430 440 450
MPVGNLVKHE IVKLGVQIDA PLHLTWSCYE GGNKHCGKCG PCYMRKVAFE
460
VNGLKDPVEY EA
Length:462
Mass (Da):51,977
Last modified:August 2, 2005 - v1
Checksum:i82D7F8FA62F7F00C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000077 Genomic DNA. Translation: AAY79696.1.
RefSeqiWP_011277198.1. NC_007181.1.

Genome annotation databases

EnsemblBacteriaiAAY79696; AAY79696; Saci_0280.
GeneIDi3473885.
KEGGisai:Saci_0280.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000077 Genomic DNA. Translation: AAY79696.1.
RefSeqiWP_011277198.1. NC_007181.1.

3D structure databases

ProteinModelPortaliQ4JBY3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi330779.Saci_0280.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAY79696; AAY79696; Saci_0280.
GeneIDi3473885.
KEGGisai:Saci_0280.

Phylogenomic databases

eggNOGiarCOG00039. Archaea.
COG0449. LUCA.
COG0603. LUCA.
HOGENOMiHOG000270539.
KOiK06920.
OMAiNEMEFVR.

Enzyme and pathway databases

UniPathwayiUPA00391.

Family and domain databases

CDDicd01995. ExsB. 1 hit.
Gene3Di3.40.50.620. 1 hit.
3.60.20.10. 1 hit.
HAMAPiMF_01633. QueC. 1 hit.
InterProiIPR017932. GATase_2_dom.
IPR029055. Ntn_hydrolases_N.
IPR018317. QueC.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF13537. GATase_7. 1 hit.
PF06508. QueC. 1 hit.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR00364. TIGR00364. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQUEC_SULAC
AccessioniPrimary (citable) accession number: Q4JBY3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: August 2, 2005
Last modified: November 2, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.