Reviewed, UniProtKB/Swiss-Prot Q4JBP0 (SYL1_SULAC)

Names and origin

Protein names

Recommended name:
    Leucyl-tRNA synthetase 1
    EC=6.1.1.4
Alternative name(s):
    Leucine--tRNA ligase 1
      Short name=LeuRS 1

Gene names

Name:	leuS1
Ordered Locus Names:	Saci_0373

Organism

Sulfolobus acidocaldarius [Complete proteome] [HAMAP]

Taxonomic identifier

2285 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus

Protein attributes

Sequence length	942 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP MF_00049
Subcellular location	Cytoplasm. HAMAP MF_00049
Sequence similarities	Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	leucyl-tRNA aminoacylation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP leucine-tRNA ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 942	942	Leucyl-tRNA synthetase 1 HAMAP MF_00049		PRO_0000152142
Regions
	Motif	39 – 49	11	"HIGH" region HAMAP MF_00049
	Motif	624 – 628	5	"KMSKS" region HAMAP MF_00049
Sites
	Binding site	627	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4JBP0-1 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: C62D780A5A6C432F	FASTA	942	108,215
	10 20 30 40 50 60 MDFLNEIASK WQKVWDSERV YEADVDRTKE KKFITVAFPY TNSPLHIGHG RTYITADIYA 70 80 90 100 110 120 RYLRMKGYNV LFPFAFQFTG TPILSIADAV KRGDEEIIST FTNVYQIPIG VISKFSDPSY 130 140 150 160 170 180 LSAYFKEDMR NTALTLGLSI DRRREFTTID PAFERFVQWQ YKRLQEIGYI KKEKAPVAYC 190 200 210 220 230 240 PVDEFPVGMH DTRGDIEPEI IDLDVIYFQG EKLLFLTATS RPETIFGAVA ILINPDSDYS 250 260 270 280 290 300 IVVDNKNGKR LVMSTEAFKK LSFQMSLTEE ERKKGGELIG LNVTNPVTLK KLTVLPSKYV 310 320 330 340 350 360 ESKQGTGVVM AVPAHEPLHY LALSELKESF EIVPVIKSED YGDFPAMEVL ETAQTTSAQE 370 380 390 400 410 420 LKDYIDTLYR IEFHKGSIRD EVVDLVPDYM KQFVGERIAG KSVREARSSV VELLRNLGVH 430 440 450 460 470 480 GNIYEIINGP VYCRCGAEVV VKVFDDQWFI DYSNSTWKSS VLKSLDKIEI LPQDAKREIS 490 500 510 520 530 540 KIIFNMKPRP FTRSRGLGVR LPWDDRQIID SLSDSTIYTV FYIVANKVKS YPTSILNERF 550 560 570 580 590 600 WDYVVLGRGD SSQLSRELGI PKEQLEELRM EVEYWYPVDS RHSGRDLVQN HIPYYLYHHV 610 620 630 640 650 660 GVLGEDKVPK RIVLNGFIRV GGKKMSKSFG NVYPLNKAIR EYGVDTVRLA LTSTSSLSDD 670 680 690 700 710 720 IEFSPNIAKS IGEQLKHIHD FIENLIKLQS VNEIRKVDLW ISSLISEYID LIDNCLSNLD 730 740 750 760 770 780 LRTAYKTIYY DIYEDLKDYL ELGNGKINSD IIKNVISVWI RLMAPFTPHL AEELWHKLDN 790 800 810 820 830 840 SLVVRQRFPS KGELQYDKRA LLEIEYLRYT IDLINSMKSK MSKEPETVII YVNEDNTQRD 850 860 870 880 890 900 LIRKAIESLK ERKSLPDFEK EVGDREMARL AYEIAGDLPD KIKNLAEIGI NESEILTSNA 910 920 930 940 QFLLNKLDVK EIYIYNSKDP STPDIKGKKS IALPYKPGII LT

References

[1]

"The genome of Sulfolobus acidocaldarius, a model organism of the Crenarchaeota." Chen L., Bruegger K., Skovgaard M., Redder P., She Q., Torarinsson E., Greve B., Awayez M., Zibat A., Klenk H.-P., Garrett R.A. J. Bacteriol. 187:4992-4999(2005) [PubMed: 15995215] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 33909 / DSM 639 / IFO 15157 / JCM 8929 / NCIB 11770.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000077 Genomic DNA. Translation: AAY79789.1.
RefSeq	YP_255082.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3473317.
GenomeReviews	Gene locus Saci_0373 in contig CP000077_GR.
KEGG	sai:Saci_0373.
NMPDR	fig|330779.3.peg.1304.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q4JBP0.
OMA	Q4JBP0. HGRTYIT.
Enzyme and pathway databases
BioCyc	SACI330779:SACI_0373-MON.
BRENDA	6.1.1.4. 434.
Family and domain databases
HAMAP	MF_00049. [Tree]
InterPro	IPR015413. aa-tRNA-synt_I. IPR001412. aa-tRNA-synth_I_CS. IPR014729. Rossmann-like_a/b/a_fold. IPR013155. V/L/I-tRNA-synth_anticodon-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
Pfam	PF08264. Anticodon_1. 1 hit. PF09334. tRNA-synt_1g. 2 hits. [Graphical view]
PROSITE	PS00178. AA_TRNA_LIGASE_I. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYL1_SULAC

Accession

Primary (citable) accession number: Q4JBP0

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2005
Last sequence update:	August 2, 2005
Last modified:	June 16, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)