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Protein

Leucine--tRNA ligase 1

Gene

leuS1

Organism
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei627ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase 1UniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetase 1UniRule annotation
Short name:
LeuRS 1UniRule annotation
Gene namesi
Name:leuS1UniRule annotation
Ordered Locus Names:Saci_0373
OrganismiSulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Taxonomic identifieri330779 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001018 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001521421 – 942Leucine--tRNA ligase 1Add BLAST942

Interactioni

Protein-protein interaction databases

STRINGi330779.Saci_0373

Structurei

3D structure databases

ProteinModelPortaliQ4JBP0
SMRiQ4JBP0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi39 – 49"HIGH" regionAdd BLAST11
Motifi624 – 628"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00809 Archaea
COG0495 LUCA
HOGENOMiHOG000216620
KOiK01869
OMAiIVKDRRY
OrthoDBiPOG093Z006D

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_A Leu_tRNA_synth_A, 1 hit
InterProiView protein in InterPro
IPR002300 aa-tRNA-synth_Ia
IPR020791 Leu-tRNA-lgase_arc
IPR004493 Leu-tRNA-synth_Ia_arc/euk
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR11946:SF51 PTHR11946:SF51, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 2 hits
TIGRFAMsiTIGR00395 leuS_arch, 1 hit

Sequencei

Sequence statusi: Complete.

Q4JBP0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFLNEIASK WQKVWDSERV YEADVDRTKE KKFITVAFPY TNSPLHIGHG
60 70 80 90 100
RTYITADIYA RYLRMKGYNV LFPFAFQFTG TPILSIADAV KRGDEEIIST
110 120 130 140 150
FTNVYQIPIG VISKFSDPSY LSAYFKEDMR NTALTLGLSI DRRREFTTID
160 170 180 190 200
PAFERFVQWQ YKRLQEIGYI KKEKAPVAYC PVDEFPVGMH DTRGDIEPEI
210 220 230 240 250
IDLDVIYFQG EKLLFLTATS RPETIFGAVA ILINPDSDYS IVVDNKNGKR
260 270 280 290 300
LVMSTEAFKK LSFQMSLTEE ERKKGGELIG LNVTNPVTLK KLTVLPSKYV
310 320 330 340 350
ESKQGTGVVM AVPAHEPLHY LALSELKESF EIVPVIKSED YGDFPAMEVL
360 370 380 390 400
ETAQTTSAQE LKDYIDTLYR IEFHKGSIRD EVVDLVPDYM KQFVGERIAG
410 420 430 440 450
KSVREARSSV VELLRNLGVH GNIYEIINGP VYCRCGAEVV VKVFDDQWFI
460 470 480 490 500
DYSNSTWKSS VLKSLDKIEI LPQDAKREIS KIIFNMKPRP FTRSRGLGVR
510 520 530 540 550
LPWDDRQIID SLSDSTIYTV FYIVANKVKS YPTSILNERF WDYVVLGRGD
560 570 580 590 600
SSQLSRELGI PKEQLEELRM EVEYWYPVDS RHSGRDLVQN HIPYYLYHHV
610 620 630 640 650
GVLGEDKVPK RIVLNGFIRV GGKKMSKSFG NVYPLNKAIR EYGVDTVRLA
660 670 680 690 700
LTSTSSLSDD IEFSPNIAKS IGEQLKHIHD FIENLIKLQS VNEIRKVDLW
710 720 730 740 750
ISSLISEYID LIDNCLSNLD LRTAYKTIYY DIYEDLKDYL ELGNGKINSD
760 770 780 790 800
IIKNVISVWI RLMAPFTPHL AEELWHKLDN SLVVRQRFPS KGELQYDKRA
810 820 830 840 850
LLEIEYLRYT IDLINSMKSK MSKEPETVII YVNEDNTQRD LIRKAIESLK
860 870 880 890 900
ERKSLPDFEK EVGDREMARL AYEIAGDLPD KIKNLAEIGI NESEILTSNA
910 920 930 940
QFLLNKLDVK EIYIYNSKDP STPDIKGKKS IALPYKPGII LT
Length:942
Mass (Da):108,215
Last modified:August 2, 2005 - v1
Checksum:iC62D780A5A6C432F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000077 Genomic DNA Translation: AAY79789.1
RefSeqiWP_011277291.1, NC_007181.1

Genome annotation databases

EnsemblBacteriaiAAY79789; AAY79789; Saci_0373
GeneIDi3473317
KEGGisai:Saci_0373
PATRICifig|330779.12.peg.371

Similar proteinsi

Entry informationi

Entry nameiSYL1_SULAC
AccessioniPrimary (citable) accession number: Q4JBP0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: August 2, 2005
Last modified: March 28, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health