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Q4JBP0

- SYL1_SULAC

UniProt

Q4JBP0 - SYL1_SULAC

Protein

Leucine--tRNA ligase 1

Gene

leuS1

Organism
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (02 Aug 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei627 – 6271ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSACI330779:GH9J-371-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligase 1UniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetase 1UniRule annotation
    Short name:
    LeuRS 1UniRule annotation
    Gene namesi
    Name:leuS1UniRule annotation
    Ordered Locus Names:Saci_0373
    OrganismiSulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
    Taxonomic identifieri330779 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
    ProteomesiUP000001018: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 942942Leucine--tRNA ligase 1PRO_0000152142Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi330779.Saci_0373.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4JBP0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi39 – 4911"HIGH" regionAdd
    BLAST
    Motifi624 – 6285"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000216620.
    KOiK01869.
    OMAiQFTGTPI.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_A. Leu_tRNA_synth_A.
    InterProiIPR002300. aa-tRNA-synth_Ia.
    IPR020791. Leu-tRNA-lgase_arc.
    IPR004493. Leu-tRNA-synth_Ia_arc/euk.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 2 hits.
    TIGRFAMsiTIGR00395. leuS_arch. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q4JBP0-1 [UniParc]FASTAAdd to Basket

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    MDFLNEIASK WQKVWDSERV YEADVDRTKE KKFITVAFPY TNSPLHIGHG    50
    RTYITADIYA RYLRMKGYNV LFPFAFQFTG TPILSIADAV KRGDEEIIST 100
    FTNVYQIPIG VISKFSDPSY LSAYFKEDMR NTALTLGLSI DRRREFTTID 150
    PAFERFVQWQ YKRLQEIGYI KKEKAPVAYC PVDEFPVGMH DTRGDIEPEI 200
    IDLDVIYFQG EKLLFLTATS RPETIFGAVA ILINPDSDYS IVVDNKNGKR 250
    LVMSTEAFKK LSFQMSLTEE ERKKGGELIG LNVTNPVTLK KLTVLPSKYV 300
    ESKQGTGVVM AVPAHEPLHY LALSELKESF EIVPVIKSED YGDFPAMEVL 350
    ETAQTTSAQE LKDYIDTLYR IEFHKGSIRD EVVDLVPDYM KQFVGERIAG 400
    KSVREARSSV VELLRNLGVH GNIYEIINGP VYCRCGAEVV VKVFDDQWFI 450
    DYSNSTWKSS VLKSLDKIEI LPQDAKREIS KIIFNMKPRP FTRSRGLGVR 500
    LPWDDRQIID SLSDSTIYTV FYIVANKVKS YPTSILNERF WDYVVLGRGD 550
    SSQLSRELGI PKEQLEELRM EVEYWYPVDS RHSGRDLVQN HIPYYLYHHV 600
    GVLGEDKVPK RIVLNGFIRV GGKKMSKSFG NVYPLNKAIR EYGVDTVRLA 650
    LTSTSSLSDD IEFSPNIAKS IGEQLKHIHD FIENLIKLQS VNEIRKVDLW 700
    ISSLISEYID LIDNCLSNLD LRTAYKTIYY DIYEDLKDYL ELGNGKINSD 750
    IIKNVISVWI RLMAPFTPHL AEELWHKLDN SLVVRQRFPS KGELQYDKRA 800
    LLEIEYLRYT IDLINSMKSK MSKEPETVII YVNEDNTQRD LIRKAIESLK 850
    ERKSLPDFEK EVGDREMARL AYEIAGDLPD KIKNLAEIGI NESEILTSNA 900
    QFLLNKLDVK EIYIYNSKDP STPDIKGKKS IALPYKPGII LT 942
    Length:942
    Mass (Da):108,215
    Last modified:August 2, 2005 - v1
    Checksum:iC62D780A5A6C432F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000077 Genomic DNA. Translation: AAY79789.1.
    RefSeqiYP_255082.1. NC_007181.1.

    Genome annotation databases

    EnsemblBacteriaiAAY79789; AAY79789; Saci_0373.
    GeneIDi3473317.
    KEGGisai:Saci_0373.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000077 Genomic DNA. Translation: AAY79789.1 .
    RefSeqi YP_255082.1. NC_007181.1.

    3D structure databases

    ProteinModelPortali Q4JBP0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 330779.Saci_0373.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAY79789 ; AAY79789 ; Saci_0373 .
    GeneIDi 3473317.
    KEGGi sai:Saci_0373.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000216620.
    KOi K01869.
    OMAi QFTGTPI.

    Enzyme and pathway databases

    BioCyci SACI330779:GH9J-371-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_A. Leu_tRNA_synth_A.
    InterProi IPR002300. aa-tRNA-synth_Ia.
    IPR020791. Leu-tRNA-lgase_arc.
    IPR004493. Leu-tRNA-synth_Ia_arc/euk.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 2 hits.
    TIGRFAMsi TIGR00395. leuS_arch. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome of Sulfolobus acidocaldarius, a model organism of the Crenarchaeota."
      Chen L., Bruegger K., Skovgaard M., Redder P., She Q., Torarinsson E., Greve B., Awayez M., Zibat A., Klenk H.-P., Garrett R.A.
      J. Bacteriol. 187:4992-4999(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770.

    Entry informationi

    Entry nameiSYL1_SULAC
    AccessioniPrimary (citable) accession number: Q4JBP0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2005
    Last sequence update: August 2, 2005
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3