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Q4JBG7 (SYW_SULAC) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Tryptophan--tRNA ligase
EC=6.1.1.2
Alternative name(s):
Tryptophanyl-tRNA synthetase
Short name=TrpRS
Gene names
Name:trpS
Ordered Locus Names:Saci_0450
OrganismSulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) [Complete proteome] [HAMAP]
Taxonomic identifier330779 [NCBI]
Taxonomic lineageArchaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus ›

Protein attributes

Sequence length381 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp). HAMAP-Rule MF_00140

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00140.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processtryptophanyl-tRNA aminoacylation

Inferred from electronic annotation. Source: HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: HAMAP

tryptophan-tRNA ligase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 381381Tryptophan--tRNA ligase HAMAP-Rule MF_00140
PRO_0000136732

Regions

Motif82 – 909"HIGH" region HAMAP-Rule MF_00140
Motif254 – 2585"KMSKS" region HAMAP-Rule MF_00140

Sequences

Sequence LengthMass (Da)Tools
Q4JBG7 [UniParc].

Last modified August 2, 2005. Version 1.
Checksum: AB6DCEFB7638A3D0

FASTA38144,604
        10         20         30         40         50         60 
MAQDFTVTPW EVKGKVDYDK LIVQFGTQKM TSELKERAKR AINDELHVML RRDVFFSHRD 

        70         80         90        100        110        120 
FDLILNDYEK GNGFFLYTGR APSLGMHIGH LIPFIFTKWL QEKFKVNVYI EITDDEKFLR 

       130        140        150        160        170        180 
NVDYTLDQTK EWSYENILDI IAVGFDPNKT FIFQDTEYIK NMYPLSVKIA KKLTFNEVRA 

       190        200        210        220        230        240 
TFGLDTSSNI GIIFYPALQI VPTMFEKRRC LIPAGIDQDP YWRLQRDIAE SLGYFKAAQI 

       250        260        270        280        290        300 
HSKFLPPLTG PEGKMSSSQP ETAIYLTDDP KTVERKIMKY AFSGGQATVE LHRKYGGNPD 

       310        320        330        340        350        360 
IDVAFQWLYM FFEPDDQRIR KIEEDYRSGA MLTGELKQIL VDKLNAFLEE HREKREKAKD 

       370        380 
LVNVFKFDGD LARDMWKRIH V

« Hide

References

[1]"The genome of Sulfolobus acidocaldarius, a model organism of the Crenarchaeota."
Chen L., Bruegger K., Skovgaard M., Redder P., She Q., Torarinsson E., Greve B., Awayez M., Zibat A., Klenk H.-P., Garrett R.A.
J. Bacteriol. 187:4992-4999(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000077 Genomic DNA. Translation: AAY79862.1.
RefSeqYP_255155.1. NC_007181.1.

3D structure databases

ProteinModelPortalQ4JBG7.
ModBaseSearch...

Protein-protein interaction databases

STRING330779.Saci_0450.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAY79862; AAY79862; Saci_0450.
GeneID3474542.
KEGGsai:Saci_0450.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0180.
HOGENOMHOG000224742.
KOK01867.
OMAKTGGRET.
ProtClustDBPRK12285.

Enzyme and pathway databases

BioCycSACI330779:GH9J-447-MONOMER.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_00140_A. Trp_tRNA_synth_A.
InterProIPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR020653. Tryptophan-tRNA-ligase_arc.
[Graphical view]
PANTHERPTHR10055. PTHR10055. 1 hit.
PfamPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSPR01039. TRNASYNTHTRP.
TIGRFAMsTIGR00233. trpS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYW_SULAC
AccessionPrimary (citable) accession number: Q4JBG7
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: August 2, 2005
Last modified: May 29, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries

SIMILARITY comments

Index of protein domains and families

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