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Q4JBG7

- SYW_SULAC

UniProt

Q4JBG7 - SYW_SULAC

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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. tryptophan-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. tryptophanyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSACI330779:GH9J-447-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:Saci_0450
OrganismiSulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Taxonomic identifieri330779 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000001018: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 381381Tryptophan--tRNA ligasePRO_0000136732Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi330779.Saci_0450.

Structurei

3D structure databases

ProteinModelPortaliQ4JBG7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi82 – 909"HIGH" region
Motifi254 – 2585"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0180.
HOGENOMiHOG000224742.
KOiK01867.
OMAiEFVVTPW.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00140_A. Trp_tRNA_synth_A.
InterProiIPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR020653. Tryptophan-tRNA-ligase_arc.
[Graphical view]
PANTHERiPTHR10055. PTHR10055. 1 hit.
PfamiPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSiPR01039. TRNASYNTHTRP.
TIGRFAMsiTIGR00233. trpS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4JBG7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAQDFTVTPW EVKGKVDYDK LIVQFGTQKM TSELKERAKR AINDELHVML
60 70 80 90 100
RRDVFFSHRD FDLILNDYEK GNGFFLYTGR APSLGMHIGH LIPFIFTKWL
110 120 130 140 150
QEKFKVNVYI EITDDEKFLR NVDYTLDQTK EWSYENILDI IAVGFDPNKT
160 170 180 190 200
FIFQDTEYIK NMYPLSVKIA KKLTFNEVRA TFGLDTSSNI GIIFYPALQI
210 220 230 240 250
VPTMFEKRRC LIPAGIDQDP YWRLQRDIAE SLGYFKAAQI HSKFLPPLTG
260 270 280 290 300
PEGKMSSSQP ETAIYLTDDP KTVERKIMKY AFSGGQATVE LHRKYGGNPD
310 320 330 340 350
IDVAFQWLYM FFEPDDQRIR KIEEDYRSGA MLTGELKQIL VDKLNAFLEE
360 370 380
HREKREKAKD LVNVFKFDGD LARDMWKRIH V
Length:381
Mass (Da):44,604
Last modified:August 2, 2005 - v1
Checksum:iAB6DCEFB7638A3D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000077 Genomic DNA. Translation: AAY79862.1.
RefSeqiYP_255155.1. NC_007181.1.

Genome annotation databases

EnsemblBacteriaiAAY79862; AAY79862; Saci_0450.
GeneIDi3474542.
KEGGisai:Saci_0450.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000077 Genomic DNA. Translation: AAY79862.1 .
RefSeqi YP_255155.1. NC_007181.1.

3D structure databases

ProteinModelPortali Q4JBG7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 330779.Saci_0450.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY79862 ; AAY79862 ; Saci_0450 .
GeneIDi 3474542.
KEGGi sai:Saci_0450.

Phylogenomic databases

eggNOGi COG0180.
HOGENOMi HOG000224742.
KOi K01867.
OMAi EFVVTPW.

Enzyme and pathway databases

BioCyci SACI330779:GH9J-447-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00140_A. Trp_tRNA_synth_A.
InterProi IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR020653. Tryptophan-tRNA-ligase_arc.
[Graphical view ]
PANTHERi PTHR10055. PTHR10055. 1 hit.
Pfami PF00579. tRNA-synt_1b. 1 hit.
[Graphical view ]
PRINTSi PR01039. TRNASYNTHTRP.
TIGRFAMsi TIGR00233. trpS. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome of Sulfolobus acidocaldarius, a model organism of the Crenarchaeota."
    Chen L., Bruegger K., Skovgaard M., Redder P., She Q., Torarinsson E., Greve B., Awayez M., Zibat A., Klenk H.-P., Garrett R.A.
    J. Bacteriol. 187:4992-4999(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770.

Entry informationi

Entry nameiSYW_SULAC
AccessioniPrimary (citable) accession number: Q4JBG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: August 2, 2005
Last modified: October 29, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3