Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:Saci_0450
OrganismiSulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Taxonomic identifieri330779 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001018 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001367321 – 381Tryptophan--tRNA ligaseAdd BLAST381

Interactioni

Protein-protein interaction databases

STRINGi330779.Saci_0450

Structurei

3D structure databases

ProteinModelPortaliQ4JBG7
SMRiQ4JBG7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi82 – 90"HIGH" region9
Motifi254 – 258"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01887 Archaea
COG0180 LUCA
HOGENOMiHOG000224742
KOiK01867
OMAiADILHPQ
OrthoDBiPOG093Z034D

Family and domain databases

CDDicd00806 TrpRS_core, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00140_A Trp_tRNA_synth_A, 1 hit
InterProiView protein in InterPro
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002306 Trp-tRNA-ligase
IPR020653 Tryptophan-tRNA-ligase_arc
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 1 hit
PRINTSiPR01039 TRNASYNTHTRP
TIGRFAMsiTIGR00233 trpS, 1 hit

Sequencei

Sequence statusi: Complete.

Q4JBG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQDFTVTPW EVKGKVDYDK LIVQFGTQKM TSELKERAKR AINDELHVML
60 70 80 90 100
RRDVFFSHRD FDLILNDYEK GNGFFLYTGR APSLGMHIGH LIPFIFTKWL
110 120 130 140 150
QEKFKVNVYI EITDDEKFLR NVDYTLDQTK EWSYENILDI IAVGFDPNKT
160 170 180 190 200
FIFQDTEYIK NMYPLSVKIA KKLTFNEVRA TFGLDTSSNI GIIFYPALQI
210 220 230 240 250
VPTMFEKRRC LIPAGIDQDP YWRLQRDIAE SLGYFKAAQI HSKFLPPLTG
260 270 280 290 300
PEGKMSSSQP ETAIYLTDDP KTVERKIMKY AFSGGQATVE LHRKYGGNPD
310 320 330 340 350
IDVAFQWLYM FFEPDDQRIR KIEEDYRSGA MLTGELKQIL VDKLNAFLEE
360 370 380
HREKREKAKD LVNVFKFDGD LARDMWKRIH V
Length:381
Mass (Da):44,604
Last modified:August 2, 2005 - v1
Checksum:iAB6DCEFB7638A3D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000077 Genomic DNA Translation: AAY79862.1
RefSeqiWP_011277364.1, NC_007181.1

Genome annotation databases

EnsemblBacteriaiAAY79862; AAY79862; Saci_0450
GeneIDi3474542
KEGGisai:Saci_0450
PATRICifig|330779.12.peg.448

Similar proteinsi

Entry informationi

Entry nameiSYW_SULAC
AccessioniPrimary (citable) accession number: Q4JBG7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: August 2, 2005
Last modified: March 28, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health