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Protein

Putative methylthioribose-1-phosphate isomerase

Gene

Saci_0539

Organism
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).UniRule annotation

Catalytic activityi

S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei106 – 1061SubstrateUniRule annotation
Sitei178 – 1781Transition state stabilizerUniRule annotation
Binding sitei218 – 2181SubstrateUniRule annotation
Active sitei259 – 2591Proton donorUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Methionine biosynthesis

Enzyme and pathway databases

BioCyciSACI330779:GH9J-532-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative methylthioribose-1-phosphate isomeraseUniRule annotation (EC:5.3.1.23UniRule annotation)
Short name:
M1PiUniRule annotation
Short name:
MTR-1-P isomeraseUniRule annotation
Alternative name(s):
MTNA-like proteinUniRule annotation
Short name:
aMTNAUniRule annotation
S-methyl-5-thioribose-1-phosphate isomeraseUniRule annotation
Gene namesi
Ordered Locus Names:Saci_0539
OrganismiSulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Taxonomic identifieri330779 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001018 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 367367Putative methylthioribose-1-phosphate isomerasePRO_0000401969Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi330779.Saci_0539.

Structurei

3D structure databases

ProteinModelPortaliQ4JB92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni65 – 673Substrate bindingUniRule annotation
Regioni269 – 2702Substrate bindingUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG01123. Archaea.
COG0182. LUCA.
HOGENOMiHOG000224730.
KOiK03239.
OMAiKVFNPAF.

Family and domain databases

Gene3Di1.20.120.420. 1 hit.
HAMAPiMF_01678. Salvage_MtnA.
InterProiIPR000649. IF-2B-related.
IPR005251. IF-M1Pi.
IPR011559. Initiation_fac_2B_a/b/d.
IPR027363. M1Pi_N.
[Graphical view]
PfamiPF01008. IF-2B. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00524. eIF-2B_rel. 1 hit.
TIGR00512. salvage_mtnA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4JB92-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHFPLIPMVK LEEIKQIFKP KLLPIIWNKT KLTLLDQSRL PFEKIYVDVT
60 70 80 90 100
KVEEVSDAIR TMKVRGAPAI GITAGYGMVL AIQDSISLEK AISDLTKAKK
110 120 130 140 150
ILDESRPTAV NLMWATSRML NKAKDLVEQG NAKSVKELKE LLEIEANKIF
160 170 180 190 200
EEEYEAELKI GLYGIEKVND GDTILTQCNA GGLATGTGLG TALAPAKLAN
210 220 230 240 250
ALGIKVSVIA PETRPWLQGS RLTVYELMEE NIPVTLIADT AVGLVMFKKM
260 270 280 290 300
VNSVMVGADR ILSDGHVFNK IGTFKEAVIA HELGIPFYAL APSSTFDMIS
310 320 330 340 350
TVDQVKIEER SPDEVRSIKG VYISPKEVKV YNPVFDVTPP KYVSAIITEY
360
GIIYPPFDKN MRRMLGK
Length:367
Mass (Da):40,600
Last modified:August 2, 2005 - v1
Checksum:i83FBAD50B6A72855
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000077 Genomic DNA. Translation: AAY79937.1.

Genome annotation databases

EnsemblBacteriaiAAY79937; AAY79937; Saci_0539.
KEGGisai:Saci_0539.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000077 Genomic DNA. Translation: AAY79937.1.

3D structure databases

ProteinModelPortaliQ4JB92.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi330779.Saci_0539.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAY79937; AAY79937; Saci_0539.
KEGGisai:Saci_0539.

Phylogenomic databases

eggNOGiarCOG01123. Archaea.
COG0182. LUCA.
HOGENOMiHOG000224730.
KOiK03239.
OMAiKVFNPAF.

Enzyme and pathway databases

BioCyciSACI330779:GH9J-532-MONOMER.

Family and domain databases

Gene3Di1.20.120.420. 1 hit.
HAMAPiMF_01678. Salvage_MtnA.
InterProiIPR000649. IF-2B-related.
IPR005251. IF-M1Pi.
IPR011559. Initiation_fac_2B_a/b/d.
IPR027363. M1Pi_N.
[Graphical view]
PfamiPF01008. IF-2B. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00524. eIF-2B_rel. 1 hit.
TIGR00512. salvage_mtnA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The genome of Sulfolobus acidocaldarius, a model organism of the Crenarchaeota."
    Chen L., Bruegger K., Skovgaard M., Redder P., She Q., Torarinsson E., Greve B., Awayez M., Zibat A., Klenk H.-P., Garrett R.A.
    J. Bacteriol. 187:4992-4999(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770.

Entry informationi

Entry nameiMTNA_SULAC
AccessioniPrimary (citable) accession number: Q4JB92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 30, 2010
Last sequence update: August 2, 2005
Last modified: November 11, 2015
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.