SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q4JB80

- DPO4_SULAC

UniProt

Q4JB80 - DPO4_SULAC

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
DNA polymerase IV
Gene
dbh, Saci_0554
Organism
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis By similarity.UniRule annotation

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).UniRule annotation

Cofactori

Binds 2 magnesium ions per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi7 – 71Magnesium By similarity
Sitei12 – 121Substrate discrimination By similarity
Metal bindingi105 – 1051Magnesium By similarity
Active sitei106 – 1061 By similarity

GO - Molecular functioni

  1. DNA-directed DNA polymerase activity Source: UniProtKB-HAMAP
  2. damaged DNA binding Source: InterPro
  3. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA repair Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Mutator protein, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA damage, DNA repair, DNA replication

Keywords - Ligandi

DNA-binding, Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciSACI330779:GH9J-546-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase IV (EC:2.7.7.7)
Short name:
Pol IV
Gene namesi
Name:dbh
Ordered Locus Names:Saci_0554
OrganismiSulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Taxonomic identifieri330779 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000001018: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 354354DNA polymerase IVUniRule annotation
PRO_0000173974Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi330779.Saci_0554.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 86
Helixi11 – 199
Helixi21 – 233
Beta strandi28 – 336
Beta strandi35 – 395
Beta strandi41 – 466
Helixi48 – 514
Turni52 – 543
Helixi61 – 677
Beta strandi71 – 755
Helixi78 – 9316
Beta strandi97 – 1037
Beta strandi106 – 1105
Turni112 – 1176
Helixi119 – 13719
Beta strandi141 – 1488
Helixi149 – 15911
Beta strandi164 – 1663
Helixi169 – 1713
Helixi172 – 1787
Helixi181 – 1833
Helixi189 – 1979
Helixi203 – 2086
Helixi211 – 2188
Helixi220 – 23011
Beta strandi240 – 2423
Beta strandi248 – 2569
Helixi259 – 27618
Beta strandi278 – 2803
Beta strandi282 – 2909
Beta strandi295 – 3017
Helixi308 – 32518
Beta strandi327 – 3293
Beta strandi331 – 34010

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3BQ0X-ray2.60A1-354[»]
3BQ1X-ray2.70A1-354[»]
3BQ2X-ray2.70A1-354[»]
4F4WX-ray1.90A/B1-231[»]
4F4XX-ray2.05A1-231[»]
4F4YX-ray2.34A/B1-127[»]
A/B213-227[»]
A/B277-354[»]
4F4ZX-ray2.30A/B248-354[»]
4F50X-ray2.22A1-246[»]
4HYKX-ray2.80A1-354[»]
4NLGX-ray2.40A1-354[»]
ProteinModelPortaliQ4JB80.
SMRiQ4JB80. Positions 1-344.

Miscellaneous databases

EvolutionaryTraceiQ4JB80.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 188186UmuC
Add
BLAST

Sequence similaritiesi

Contains 1 umuC domain.

Phylogenomic databases

eggNOGiCOG0389.
HOGENOMiHOG000082707.
KOiK04479.
OMAiPHGRYLT.

Family and domain databases

Gene3Di3.30.1490.100. 1 hit.
HAMAPiMF_01113. DNApol_IV.
InterProiIPR017961. DNA_pol_Y-fam_little_finger.
IPR001126. DNA_repair_prot_UmuC-like.
IPR017963. DNA_repair_prot_UmuC-like_N.
IPR022880. DNApol_IV.
IPR024728. PolY_HhH_motif.
[Graphical view]
PfamiPF00817. IMS. 1 hit.
PF11798. IMS_HHH. 1 hit.
[Graphical view]
SUPFAMiSSF100879. SSF100879. 1 hit.
PROSITEiPS50173. UMUC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4JB80-1 [UniParc]FASTAAdd to Basket

« Hide

MIVIFVDFDY FFAQVEEVLN PQYKGKPLVV CVYSGRTKTS GAVATANYEA    50
RKLGVKAGMP IIKAMQIAPS AIYVPMRKPI YEAFSNRIMN LLNKHADKIE 100
VASIDEAYLD VTNKVEGNFE NGIELARKIK QEILEKEKIT VTVGVAPNKI 150
LAKIIADKSK PNGLGVIRPT EVQDFLNELD IDEIPGIGSV LARRLNELGI 200
QKLRDILSKN YNELEKITGK AKALYLLKLA QNKYSEPVEN KSKIPHGRYL 250
TLPYNTRDVK VILPYLKKAI NEAYNKVNGI PMRITVIAIM EDLDILSKGK 300
KFKHGISIDN AYKVAEDLLR ELLVRDKRRN VRRIGVKLDN IIINKTNLSD 350
FFDI 354
Length:354
Mass (Da):39,986
Last modified:August 2, 2005 - v1
Checksum:i0EDDAEB0F30EAD35
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000077 Genomic DNA. Translation: AAY79949.1.
RefSeqiYP_255242.1. NC_007181.1.

Genome annotation databases

EnsemblBacteriaiAAY79949; AAY79949; Saci_0554.
GeneIDi3474616.
KEGGisai:Saci_0554.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000077 Genomic DNA. Translation: AAY79949.1 .
RefSeqi YP_255242.1. NC_007181.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3BQ0 X-ray 2.60 A 1-354 [» ]
3BQ1 X-ray 2.70 A 1-354 [» ]
3BQ2 X-ray 2.70 A 1-354 [» ]
4F4W X-ray 1.90 A/B 1-231 [» ]
4F4X X-ray 2.05 A 1-231 [» ]
4F4Y X-ray 2.34 A/B 1-127 [» ]
A/B 213-227 [» ]
A/B 277-354 [» ]
4F4Z X-ray 2.30 A/B 248-354 [» ]
4F50 X-ray 2.22 A 1-246 [» ]
4HYK X-ray 2.80 A 1-354 [» ]
4NLG X-ray 2.40 A 1-354 [» ]
ProteinModelPortali Q4JB80.
SMRi Q4JB80. Positions 1-344.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 330779.Saci_0554.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY79949 ; AAY79949 ; Saci_0554 .
GeneIDi 3474616.
KEGGi sai:Saci_0554.

Phylogenomic databases

eggNOGi COG0389.
HOGENOMi HOG000082707.
KOi K04479.
OMAi PHGRYLT.

Enzyme and pathway databases

BioCyci SACI330779:GH9J-546-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q4JB80.

Family and domain databases

Gene3Di 3.30.1490.100. 1 hit.
HAMAPi MF_01113. DNApol_IV.
InterProi IPR017961. DNA_pol_Y-fam_little_finger.
IPR001126. DNA_repair_prot_UmuC-like.
IPR017963. DNA_repair_prot_UmuC-like_N.
IPR022880. DNApol_IV.
IPR024728. PolY_HhH_motif.
[Graphical view ]
Pfami PF00817. IMS. 1 hit.
PF11798. IMS_HHH. 1 hit.
[Graphical view ]
SUPFAMi SSF100879. SSF100879. 1 hit.
PROSITEi PS50173. UMUC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of Sulfolobus acidocaldarius, a model organism of the Crenarchaeota."
    Chen L., Bruegger K., Skovgaard M., Redder P., She Q., Torarinsson E., Greve B., Awayez M., Zibat A., Klenk H.-P., Garrett R.A.
    J. Bacteriol. 187:4992-4999(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770.

Entry informationi

Entry nameiDPO4_SULAC
AccessioniPrimary (citable) accession number: Q4JB80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: August 2, 2005
Last modified: July 9, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi