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Q4JB80

- DPO4_SULAC

UniProt

Q4JB80 - DPO4_SULAC

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Protein

DNA polymerase IV

Gene

dbh

Organism
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis.UniRule annotation

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi7 – 71MagnesiumUniRule annotation
Sitei12 – 121Substrate discriminationUniRule annotation
Metal bindingi105 – 1051MagnesiumUniRule annotation
Active sitei106 – 1061UniRule annotation

GO - Molecular functioni

  1. damaged DNA binding Source: InterPro
  2. DNA-directed DNA polymerase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA repair Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Mutator protein, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA damage, DNA repair, DNA replication

Keywords - Ligandi

DNA-binding, Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciSACI330779:GH9J-546-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase IVUniRule annotation (EC:2.7.7.7UniRule annotation)
Short name:
Pol IVUniRule annotation
Gene namesi
Name:dbhUniRule annotation
Ordered Locus Names:Saci_0554
OrganismiSulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Taxonomic identifieri330779 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000001018: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 354354DNA polymerase IVPRO_0000173974Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi330779.Saci_0554.

Structurei

Secondary structure

1
354
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 86Combined sources
Helixi11 – 199Combined sources
Helixi21 – 233Combined sources
Beta strandi28 – 336Combined sources
Beta strandi35 – 395Combined sources
Beta strandi41 – 466Combined sources
Helixi48 – 514Combined sources
Turni52 – 543Combined sources
Helixi61 – 677Combined sources
Beta strandi71 – 755Combined sources
Helixi78 – 9316Combined sources
Beta strandi97 – 1037Combined sources
Beta strandi106 – 1105Combined sources
Turni112 – 1176Combined sources
Helixi119 – 13719Combined sources
Beta strandi141 – 1488Combined sources
Helixi149 – 15911Combined sources
Beta strandi164 – 1663Combined sources
Helixi169 – 1713Combined sources
Helixi172 – 1787Combined sources
Helixi181 – 1833Combined sources
Helixi189 – 1979Combined sources
Helixi203 – 2086Combined sources
Helixi211 – 2188Combined sources
Helixi220 – 23011Combined sources
Beta strandi240 – 2423Combined sources
Beta strandi248 – 2569Combined sources
Helixi259 – 27618Combined sources
Beta strandi278 – 2803Combined sources
Beta strandi282 – 2909Combined sources
Beta strandi295 – 3017Combined sources
Helixi308 – 32518Combined sources
Beta strandi327 – 3293Combined sources
Beta strandi331 – 34010Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3BQ0X-ray2.60A1-354[»]
3BQ1X-ray2.70A1-354[»]
3BQ2X-ray2.70A1-354[»]
4F4WX-ray1.90A/B1-231[»]
4F4XX-ray2.05A1-231[»]
4F4YX-ray2.34A/B1-231[»]
A/B249-330[»]
A/B327-354[»]
4F4ZX-ray2.30A/B248-354[»]
4F50X-ray2.22A1-246[»]
4HYKX-ray2.80A1-354[»]
4NLGX-ray2.40A1-354[»]
ProteinModelPortaliQ4JB80.
SMRiQ4JB80. Positions 1-344.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ4JB80.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 188186UmuCUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the DNA polymerase type-Y family.UniRule annotation
Contains 1 umuC domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0389.
HOGENOMiHOG000082707.
KOiK04479.
OMAiPHGRYLT.

Family and domain databases

Gene3Di3.30.1490.100. 1 hit.
HAMAPiMF_01113. DNApol_IV.
InterProiIPR017961. DNA_pol_Y-fam_little_finger.
IPR001126. DNA_repair_prot_UmuC-like.
IPR017963. DNA_repair_prot_UmuC-like_N.
IPR022880. DNApol_IV.
IPR024728. PolY_HhH_motif.
[Graphical view]
PfamiPF00817. IMS. 1 hit.
PF11798. IMS_HHH. 1 hit.
[Graphical view]
SUPFAMiSSF100879. SSF100879. 1 hit.
PROSITEiPS50173. UMUC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4JB80-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIVIFVDFDY FFAQVEEVLN PQYKGKPLVV CVYSGRTKTS GAVATANYEA
60 70 80 90 100
RKLGVKAGMP IIKAMQIAPS AIYVPMRKPI YEAFSNRIMN LLNKHADKIE
110 120 130 140 150
VASIDEAYLD VTNKVEGNFE NGIELARKIK QEILEKEKIT VTVGVAPNKI
160 170 180 190 200
LAKIIADKSK PNGLGVIRPT EVQDFLNELD IDEIPGIGSV LARRLNELGI
210 220 230 240 250
QKLRDILSKN YNELEKITGK AKALYLLKLA QNKYSEPVEN KSKIPHGRYL
260 270 280 290 300
TLPYNTRDVK VILPYLKKAI NEAYNKVNGI PMRITVIAIM EDLDILSKGK
310 320 330 340 350
KFKHGISIDN AYKVAEDLLR ELLVRDKRRN VRRIGVKLDN IIINKTNLSD

FFDI
Length:354
Mass (Da):39,986
Last modified:August 2, 2005 - v1
Checksum:i0EDDAEB0F30EAD35
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000077 Genomic DNA. Translation: AAY79949.1.
RefSeqiYP_255242.1. NC_007181.1.

Genome annotation databases

EnsemblBacteriaiAAY79949; AAY79949; Saci_0554.
GeneIDi3474616.
KEGGisai:Saci_0554.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000077 Genomic DNA. Translation: AAY79949.1 .
RefSeqi YP_255242.1. NC_007181.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3BQ0 X-ray 2.60 A 1-354 [» ]
3BQ1 X-ray 2.70 A 1-354 [» ]
3BQ2 X-ray 2.70 A 1-354 [» ]
4F4W X-ray 1.90 A/B 1-231 [» ]
4F4X X-ray 2.05 A 1-231 [» ]
4F4Y X-ray 2.34 A/B 1-231 [» ]
A/B 249-330 [» ]
A/B 327-354 [» ]
4F4Z X-ray 2.30 A/B 248-354 [» ]
4F50 X-ray 2.22 A 1-246 [» ]
4HYK X-ray 2.80 A 1-354 [» ]
4NLG X-ray 2.40 A 1-354 [» ]
ProteinModelPortali Q4JB80.
SMRi Q4JB80. Positions 1-344.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 330779.Saci_0554.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY79949 ; AAY79949 ; Saci_0554 .
GeneIDi 3474616.
KEGGi sai:Saci_0554.

Phylogenomic databases

eggNOGi COG0389.
HOGENOMi HOG000082707.
KOi K04479.
OMAi PHGRYLT.

Enzyme and pathway databases

BioCyci SACI330779:GH9J-546-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q4JB80.

Family and domain databases

Gene3Di 3.30.1490.100. 1 hit.
HAMAPi MF_01113. DNApol_IV.
InterProi IPR017961. DNA_pol_Y-fam_little_finger.
IPR001126. DNA_repair_prot_UmuC-like.
IPR017963. DNA_repair_prot_UmuC-like_N.
IPR022880. DNApol_IV.
IPR024728. PolY_HhH_motif.
[Graphical view ]
Pfami PF00817. IMS. 1 hit.
PF11798. IMS_HHH. 1 hit.
[Graphical view ]
SUPFAMi SSF100879. SSF100879. 1 hit.
PROSITEi PS50173. UMUC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of Sulfolobus acidocaldarius, a model organism of the Crenarchaeota."
    Chen L., Bruegger K., Skovgaard M., Redder P., She Q., Torarinsson E., Greve B., Awayez M., Zibat A., Klenk H.-P., Garrett R.A.
    J. Bacteriol. 187:4992-4999(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770.

Entry informationi

Entry nameiDPO4_SULAC
AccessioniPrimary (citable) accession number: Q4JB80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: August 2, 2005
Last modified: November 26, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3