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Protein

Methionine synthase

Gene

metE

Organism
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. The physiological methyl donor is unknown (By similarity).By similarity

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi212 – 2121ZincUniRule annotation
Metal bindingi214 – 2141ZincUniRule annotation
Metal bindingi295 – 2951ZincUniRule annotation

GO - Molecular functioni

  1. 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity Source: InterPro
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. methionine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Methionine biosynthesis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciSACI330779:GH9J-814-MONOMER.
UniPathwayiUPA00051.

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine synthaseUniRule annotation (EC:2.1.1.-UniRule annotation)
Alternative name(s):
Homocysteine methyltransferase
Gene namesi
Name:metEUniRule annotation
Ordered Locus Names:Saci_0828
OrganismiSulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Taxonomic identifieri330779 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000001018: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 339339Methionine synthasePRO_0000098691Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi330779.Saci_0828.

Structurei

3D structure databases

ProteinModelPortaliQ4JAI4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the archaeal MetE family.Curated

Phylogenomic databases

eggNOGiCOG0620.
HOGENOMiHOG000140559.
KOiK00549.
OMAiNYYLLAD.

Family and domain databases

HAMAPiMF_00288. MetE.
InterProiIPR002629. Met_Synth_C/arc.
IPR022921. MetE_arc.
[Graphical view]
PfamiPF01717. Meth_synt_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4JAI4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDEITILPT TVIGSYPRPK WLRETIRLHR AGKVNQEDLE EAFNDAVVTV
60 70 80 90 100
VRDHQEAGID VPTDGEMRRD EMVEFFAERL SGFKFYGHVR VWGDHYYRKP
110 120 130 140 150
SVTGKIKYNN PMLLDEVNFA KSVSYTQNLK VTITGPYTIS EWSYNEYYKT
160 170 180 190 200
QRDMAFDLAK VINQEIKNLV DIGIKVIQVD EPAIHTRKED VEWAIDSINE
210 220 230 240 250
SIKGVNVKVV LHVCYGEYSY LEPHLDKLKV DQINLALKNY NYTPVKLFKK
260 270 280 290 300
WDREIGVGVI DVHNRKIESV EEVAEDLRKL LEYFKPEMVW VNPDCGLKLL
310 320 330
PRKIALQKLI NMVKGTLIVR EELKKKGYTN TTLKPLINR
Length:339
Mass (Da):39,421
Last modified:August 2, 2005 - v1
Checksum:i624BAFE6CA7F5CE4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000077 Genomic DNA. Translation: AAY80195.1.
RefSeqiYP_255488.1. NC_007181.1.

Genome annotation databases

EnsemblBacteriaiAAY80195; AAY80195; Saci_0828.
GeneIDi3472664.
KEGGisai:Saci_0828.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000077 Genomic DNA. Translation: AAY80195.1.
RefSeqiYP_255488.1. NC_007181.1.

3D structure databases

ProteinModelPortaliQ4JAI4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi330779.Saci_0828.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAY80195; AAY80195; Saci_0828.
GeneIDi3472664.
KEGGisai:Saci_0828.

Phylogenomic databases

eggNOGiCOG0620.
HOGENOMiHOG000140559.
KOiK00549.
OMAiNYYLLAD.

Enzyme and pathway databases

UniPathwayiUPA00051.
BioCyciSACI330779:GH9J-814-MONOMER.

Family and domain databases

HAMAPiMF_00288. MetE.
InterProiIPR002629. Met_Synth_C/arc.
IPR022921. MetE_arc.
[Graphical view]
PfamiPF01717. Meth_synt_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome of Sulfolobus acidocaldarius, a model organism of the Crenarchaeota."
    Chen L., Bruegger K., Skovgaard M., Redder P., She Q., Torarinsson E., Greve B., Awayez M., Zibat A., Klenk H.-P., Garrett R.A.
    J. Bacteriol. 187:4992-4999(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770.

Entry informationi

Entry nameiMETE_SULAC
AccessioniPrimary (citable) accession number: Q4JAI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: August 2, 2005
Last modified: January 7, 2015
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.