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Q4JAI4 (METE_SULAC) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable methylcobalamin:homocysteine methyltransferase

EC=2.1.1.-
Alternative name(s):
Methionine synthase
Gene names
Name:metE
Ordered Locus Names:Saci_0828
OrganismSulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) [Complete proteome] [HAMAP]
Taxonomic identifier330779 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus

Protein attributes

Sequence length339 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a methyl group from methylcobalamin and methylcobinamide to homocysteine resulting in methionine formation By similarity. HAMAP-Rule MF_00288

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_00288

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway. HAMAP-Rule MF_00288

Sequence similarities

Belongs to the vitamin-B12 independent methionine synthase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 339339Probable methylcobalamin:homocysteine methyltransferase HAMAP-Rule MF_00288
PRO_0000098691

Sites

Metal binding2121Zinc By similarity
Metal binding2141Zinc By similarity
Metal binding2951Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4JAI4 [UniParc].

Last modified August 2, 2005. Version 1.
Checksum: 624BAFE6CA7F5CE4

FASTA33939,421
        10         20         30         40         50         60 
MSDEITILPT TVIGSYPRPK WLRETIRLHR AGKVNQEDLE EAFNDAVVTV VRDHQEAGID 

        70         80         90        100        110        120 
VPTDGEMRRD EMVEFFAERL SGFKFYGHVR VWGDHYYRKP SVTGKIKYNN PMLLDEVNFA 

       130        140        150        160        170        180 
KSVSYTQNLK VTITGPYTIS EWSYNEYYKT QRDMAFDLAK VINQEIKNLV DIGIKVIQVD 

       190        200        210        220        230        240 
EPAIHTRKED VEWAIDSINE SIKGVNVKVV LHVCYGEYSY LEPHLDKLKV DQINLALKNY 

       250        260        270        280        290        300 
NYTPVKLFKK WDREIGVGVI DVHNRKIESV EEVAEDLRKL LEYFKPEMVW VNPDCGLKLL 

       310        320        330 
PRKIALQKLI NMVKGTLIVR EELKKKGYTN TTLKPLINR 

« Hide

References

[1]"The genome of Sulfolobus acidocaldarius, a model organism of the Crenarchaeota."
Chen L., Bruegger K., Skovgaard M., Redder P., She Q., Torarinsson E., Greve B., Awayez M., Zibat A., Klenk H.-P., Garrett R.A.
J. Bacteriol. 187:4992-4999(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000077 Genomic DNA. Translation: AAY80195.1.
RefSeqYP_255488.1. NC_007181.1.

3D structure databases

ProteinModelPortalQ4JAI4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING330779.Saci_0828.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAY80195; AAY80195; Saci_0828.
GeneID3472664.
KEGGsai:Saci_0828.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0620.
HOGENOMHOG000140559.
KOK00549.
OMANYYLLAD.
ProtClustDBPRK04326.

Enzyme and pathway databases

BioCycSACI330779:GH9J-814-MONOMER.
UniPathwayUPA00051.

Family and domain databases

HAMAPMF_00288. MetE.
InterProIPR022921. MetE_arc.
IPR002629. Methionine_synth.
[Graphical view]
PfamPF01717. Meth_synt_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMETE_SULAC
AccessionPrimary (citable) accession number: Q4JAI4
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: August 2, 2005
Last modified: February 19, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways