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Q4JAI4

- METE_SULAC

UniProt

Q4JAI4 - METE_SULAC

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Protein

Methionine synthase

Gene
metE, Saci_0828
Organism
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. The physiological methyl donor is unknown By similarity.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi212 – 2121Zinc By similarity
Metal bindingi214 – 2141Zinc By similarity
Metal bindingi295 – 2951Zinc By similarity

GO - Molecular functioni

  1. 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity Source: InterPro
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. methionine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Methionine biosynthesis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciSACI330779:GH9J-814-MONOMER.
UniPathwayiUPA00051.

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine synthase (EC:2.1.1.-)
Alternative name(s):
Homocysteine methyltransferase
Gene namesi
Name:metE
Ordered Locus Names:Saci_0828
OrganismiSulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Taxonomic identifieri330779 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000001018: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 339339Methionine synthaseUniRule annotationPRO_0000098691Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi330779.Saci_0828.

Structurei

3D structure databases

ProteinModelPortaliQ4JAI4.

Family & Domainsi

Sequence similaritiesi

Belongs to the archaeal MetE family.

Phylogenomic databases

eggNOGiCOG0620.
HOGENOMiHOG000140559.
KOiK00549.
OMAiAMHVCGN.

Family and domain databases

HAMAPiMF_00288. MetE.
InterProiIPR002629. Met_Synth_C/arc.
IPR022921. MetE_arc.
[Graphical view]
PfamiPF01717. Meth_synt_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4JAI4-1 [UniParc]FASTAAdd to Basket

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MSDEITILPT TVIGSYPRPK WLRETIRLHR AGKVNQEDLE EAFNDAVVTV    50
VRDHQEAGID VPTDGEMRRD EMVEFFAERL SGFKFYGHVR VWGDHYYRKP 100
SVTGKIKYNN PMLLDEVNFA KSVSYTQNLK VTITGPYTIS EWSYNEYYKT 150
QRDMAFDLAK VINQEIKNLV DIGIKVIQVD EPAIHTRKED VEWAIDSINE 200
SIKGVNVKVV LHVCYGEYSY LEPHLDKLKV DQINLALKNY NYTPVKLFKK 250
WDREIGVGVI DVHNRKIESV EEVAEDLRKL LEYFKPEMVW VNPDCGLKLL 300
PRKIALQKLI NMVKGTLIVR EELKKKGYTN TTLKPLINR 339
Length:339
Mass (Da):39,421
Last modified:August 2, 2005 - v1
Checksum:i624BAFE6CA7F5CE4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000077 Genomic DNA. Translation: AAY80195.1.
RefSeqiYP_255488.1. NC_007181.1.

Genome annotation databases

EnsemblBacteriaiAAY80195; AAY80195; Saci_0828.
GeneIDi3472664.
KEGGisai:Saci_0828.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000077 Genomic DNA. Translation: AAY80195.1 .
RefSeqi YP_255488.1. NC_007181.1.

3D structure databases

ProteinModelPortali Q4JAI4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 330779.Saci_0828.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY80195 ; AAY80195 ; Saci_0828 .
GeneIDi 3472664.
KEGGi sai:Saci_0828.

Phylogenomic databases

eggNOGi COG0620.
HOGENOMi HOG000140559.
KOi K00549.
OMAi AMHVCGN.

Enzyme and pathway databases

UniPathwayi UPA00051 .
BioCyci SACI330779:GH9J-814-MONOMER.

Family and domain databases

HAMAPi MF_00288. MetE.
InterProi IPR002629. Met_Synth_C/arc.
IPR022921. MetE_arc.
[Graphical view ]
Pfami PF01717. Meth_synt_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of Sulfolobus acidocaldarius, a model organism of the Crenarchaeota."
    Chen L., Bruegger K., Skovgaard M., Redder P., She Q., Torarinsson E., Greve B., Awayez M., Zibat A., Klenk H.-P., Garrett R.A.
    J. Bacteriol. 187:4992-4999(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770.

Entry informationi

Entry nameiMETE_SULAC
AccessioniPrimary (citable) accession number: Q4JAI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: August 2, 2005
Last modified: September 3, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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