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Q4JAI4

- METE_SULAC

UniProt

Q4JAI4 - METE_SULAC

Protein

Methionine synthase

Gene

metE

Organism
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (02 Aug 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. The physiological methyl donor is unknown By similarity.By similarity

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi212 – 2121ZincUniRule annotation
    Metal bindingi214 – 2141ZincUniRule annotation
    Metal bindingi295 – 2951ZincUniRule annotation

    GO - Molecular functioni

    1. 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity Source: InterPro
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. methionine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Methionine biosynthesis

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciSACI330779:GH9J-814-MONOMER.
    UniPathwayiUPA00051.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Methionine synthaseUniRule annotation (EC:2.1.1.-UniRule annotation)
    Alternative name(s):
    Homocysteine methyltransferase
    Gene namesi
    Name:metEUniRule annotation
    Ordered Locus Names:Saci_0828
    OrganismiSulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
    Taxonomic identifieri330779 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
    ProteomesiUP000001018: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 339339Methionine synthasePRO_0000098691Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi330779.Saci_0828.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4JAI4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the archaeal MetE family.Curated

    Phylogenomic databases

    eggNOGiCOG0620.
    HOGENOMiHOG000140559.
    KOiK00549.
    OMAiAMHVCGN.

    Family and domain databases

    HAMAPiMF_00288. MetE.
    InterProiIPR002629. Met_Synth_C/arc.
    IPR022921. MetE_arc.
    [Graphical view]
    PfamiPF01717. Meth_synt_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4JAI4-1 [UniParc]FASTAAdd to Basket

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    MSDEITILPT TVIGSYPRPK WLRETIRLHR AGKVNQEDLE EAFNDAVVTV    50
    VRDHQEAGID VPTDGEMRRD EMVEFFAERL SGFKFYGHVR VWGDHYYRKP 100
    SVTGKIKYNN PMLLDEVNFA KSVSYTQNLK VTITGPYTIS EWSYNEYYKT 150
    QRDMAFDLAK VINQEIKNLV DIGIKVIQVD EPAIHTRKED VEWAIDSINE 200
    SIKGVNVKVV LHVCYGEYSY LEPHLDKLKV DQINLALKNY NYTPVKLFKK 250
    WDREIGVGVI DVHNRKIESV EEVAEDLRKL LEYFKPEMVW VNPDCGLKLL 300
    PRKIALQKLI NMVKGTLIVR EELKKKGYTN TTLKPLINR 339
    Length:339
    Mass (Da):39,421
    Last modified:August 2, 2005 - v1
    Checksum:i624BAFE6CA7F5CE4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000077 Genomic DNA. Translation: AAY80195.1.
    RefSeqiYP_255488.1. NC_007181.1.

    Genome annotation databases

    EnsemblBacteriaiAAY80195; AAY80195; Saci_0828.
    GeneIDi3472664.
    KEGGisai:Saci_0828.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000077 Genomic DNA. Translation: AAY80195.1 .
    RefSeqi YP_255488.1. NC_007181.1.

    3D structure databases

    ProteinModelPortali Q4JAI4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 330779.Saci_0828.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAY80195 ; AAY80195 ; Saci_0828 .
    GeneIDi 3472664.
    KEGGi sai:Saci_0828.

    Phylogenomic databases

    eggNOGi COG0620.
    HOGENOMi HOG000140559.
    KOi K00549.
    OMAi AMHVCGN.

    Enzyme and pathway databases

    UniPathwayi UPA00051 .
    BioCyci SACI330779:GH9J-814-MONOMER.

    Family and domain databases

    HAMAPi MF_00288. MetE.
    InterProi IPR002629. Met_Synth_C/arc.
    IPR022921. MetE_arc.
    [Graphical view ]
    Pfami PF01717. Meth_synt_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of Sulfolobus acidocaldarius, a model organism of the Crenarchaeota."
      Chen L., Bruegger K., Skovgaard M., Redder P., She Q., Torarinsson E., Greve B., Awayez M., Zibat A., Klenk H.-P., Garrett R.A.
      J. Bacteriol. 187:4992-4999(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770.

    Entry informationi

    Entry nameiMETE_SULAC
    AccessioniPrimary (citable) accession number: Q4JAI4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2005
    Last sequence update: August 2, 2005
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3