Q4JAG3 (Q4JAG3_SULAC) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Non-canonical purine NTP pyrophosphatase HAMAP MF_01405
EC=3.6.1.19 HAMAP MF_01405

Alternative name(s):
Non-standard purine NTP pyrophosphatase HAMAP MF_01405
Nucleoside-triphosphate diphosphatase HAMAP MF_01405
Nucleoside-triphosphate pyrophosphatase HAMAP MF_01405

Gene names

Ordered Locus Names:

Saci_0849

Organism

Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) [Complete proteome] [HAMAP] EMBL AAY80216.1

Taxonomic identifier

330779 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus

Protein attributes

Sequence length	191 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP/dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions By similarity. HAMAP MF_01405
Catalytic activity	A nucleoside triphosphate + H2O = a nucleotide + diphosphate. HAMAP MF_01405
Cofactor	Binds 1 divalent metal cation ion per subunit; can use either magnesium or manganese By similarity. HAMAP MF_01405
Subunit structure	Homodimer By similarity. HAMAP MF_01405
Sequence similarities	Belongs to the HAM1 NTPase family. HAMAP MF_01405

Ontologies

Keywords
Biological process	Nucleotide metabolism HAMAP MF_01405
Ligand	Magnesium HAMAP MF_01405 Manganese HAMAP MF_01405 Metal-binding HAMAP MF_01405 Nucleotide-binding HAMAP MF_01405
Molecular function	Hydrolase HAMAP MF_01405 EMBL AAY80216.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro nucleoside-triphosphate diphosphatase activity Inferred from electronic annotation. Source: HAMAP nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Region	13 – 18	6	Substrate binding By similarity HAMAP MF_01405
	Region	71 – 72	2	Substrate binding By similarity HAMAP MF_01405
Sites
	Metal binding	42	1	Magnesium or manganese By similarity HAMAP MF_01405
	Metal binding	71	1	Magnesium or manganese By similarity HAMAP MF_01405
	Binding site	149	1	Substrate By similarity HAMAP MF_01405
	Binding site	169	1	Substrate By similarity HAMAP MF_01405
	Binding site	175	1	Substrate By similarity HAMAP MF_01405

Sequences

	Sequence		Length	Mass (Da)
	Q4JAG3 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: 00A1D38B5ACE0449	FASTA	191	21,935
	10 20 30 40 50 60 MKKEEKREII LVTSNENKFK EMNSIAQNFN VSLIWFNIPK VEIQADSLEE IVKFSAIIAY 70 80 90 100 110 120 NQINRPLIVE DSGLFIEALN GFPGPYSNYV RRKIGMEGII RLLEGEKNRK AYFSTVLAYV 130 140 150 160 170 180 DSTQLKLFEG RVYGSISTEI RGTKGFGYDP IFIPDGVNLT FGEMSTEEKN KYSHRAIAFR 190 KFLEYLATYT V

References

[1]

"The genome of Sulfolobus acidocaldarius, a model organism of the Crenarchaeota." Chen L., Bruegger K., Skovgaard M., Redder P., She Q., Torarinsson E., Greve B., Awayez M., Zibat A., Klenk H.-P., Garrett R.A. J. Bacteriol. 187:4992-4999(2005) [PubMed: 15995215] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 33909 / DSM 639 / IFO 15157 / JCM 8929 / NCIB 11770 and ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000077 Genomic DNA. Translation: AAY80216.1.
RefSeq	YP_255509.1. NC_007181.1.
3D structure databases
ProteinModelPortal	Q4JAG3.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3472720.
GenomeReviews	Gene locus Saci_0849 in contig CP000077_GR.
KEGG	sai:Saci_0849.
NMPDR	fig|330779.3.peg.828.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG697237.
OMA	VEDSGFF.
PhylomeDB	Q4JAG3.
ProtClustDB	CLSK2752149.
Enzyme and pathway databases
BioCyc	SACI330779:SACI_0849-MONOMER.
Family and domain databases
HAMAP	MF_01405. Non_canon_purine_NTPase. [Tree]
InterPro	IPR002637. Ham1p-like. IPR020922. Nucleoside-triphosphatase. [Graphical view]
KO	K02428.
PANTHER	PTHR11067. Ham1p_like. 1 hit.
Pfam	PF01725. Ham1p_like. 1 hit. [Graphical view]
TIGRFAMs	TIGR00042. TIGR00042. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q4JAG3_SULAC

Accession

Primary (citable) accession number: Q4JAG3

Entry history

Integrated into UniProtKB/TrEMBL:	August 2, 2005
Last sequence update:	August 2, 2005
Last modified:	December 14, 2011
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)