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Q4J9S8

- PCKG_SULAC

UniProt

Q4J9S8 - PCKG_SULAC

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Protein
Phosphoenolpyruvate carboxykinase [GTP]
Gene
pckG, Saci_1100
Organism
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle By similarity.UniRule annotation

Catalytic activityi

GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.UniRule annotation

Cofactori

Binds 1 manganese ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei87 – 871Substrate By similarity
Binding sitei211 – 2111Substrate; via amide nitrogen By similarity
Metal bindingi218 – 2181Manganese By similarity
Binding sitei218 – 2181Substrate By similarity
Metal bindingi237 – 2371Manganese; via tele nitrogen By similarity
Binding sitei258 – 2581Substrate By similarity
Active sitei260 – 2601 By similarity
Metal bindingi275 – 2751Manganese By similarity
Binding sitei367 – 3671GTP By similarity
Binding sitei398 – 3981GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP
  3. phosphoenolpyruvate carboxykinase (GTP) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Gluconeogenesis

Keywords - Ligandi

GTP-binding, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSACI330779:GH9J-1081-MONOMER.
UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxykinase [GTP] (EC:4.1.1.32)
Short name:
PEP carboxykinase
Short name:
PEPCK
Gene namesi
Name:pckG
Ordered Locus Names:Saci_1100
OrganismiSulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Taxonomic identifieri330779 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000001018: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 604604Phosphoenolpyruvate carboxykinase [GTP]UniRule annotation
PRO_0000103621Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi330779.Saci_1100.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni365 – 3673Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1274.
HOGENOMiHOG000191700.
KOiK01596.
OMAiSEFLLYR.

Family and domain databases

Gene3Di3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPiMF_00452. PEPCK_GTP.
InterProiIPR013035. PEP_carboxykinase_C.
IPR008209. PEP_carboxykinase_GTP.
IPR008210. PEP_carboxykinase_N.
[Graphical view]
PANTHERiPTHR11561. PTHR11561. 1 hit.
PfamiPF00821. PEPCK. 1 hit.
[Graphical view]
PIRSFiPIRSF001348. PEP_carboxykinase_GTP. 1 hit.
SUPFAMiSSF68923. SSF68923. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4J9S8-1 [UniParc]FASTAAdd to Basket

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MKVDLSPLNG IISDKAFQKL KSINNPSLVH FLSKTIELTT PDRVYVSFGE    50
EKDREYVKKR ALETKEEIKL KMEGHTIHFD HPLDQARARE DTFILTDEKI 100
PFVNTKPRDE GLREMLSLLK GSMKGREMYV GFYSLGPRNS KFSILAVQIT 150
DSPYVIHSEN ILYRNAFEDF YGDKPFLKFI HSKGQLDIKK RRIMIDVKEN 200
TVYSVNTTYA GNSVGLKKLA LRLTVTKAVN EGWLSEHMAI VGFEGNRGTH 250
YFTASFPSGS GKTSTSMLGS LISDDLAFIK EIDGVCRAVN PEIGIFGIIQ 300
GINERDDPVI WDVLHKPGEV IFSNVLMTDD GGVYWEGSEV EKPEKGYNYE 350
GAWTKESGKP ASHPNARFTS PLTSFSNLDK DYDNPQGVVI DGIIFGVRDY 400
STLVPVTEAF SWEHGVITIG ASMESSRTSA VIGKADVLEF NPMAILDFMP 450
LSLGKYLNNY LTFGRNLKYV PKIFSFNYFL KDENNKFLNS KEDKRVWVKW 500
AVKRVESETD AIYTPVGFIP YYEDLSKLFN STLGKQYTKE AYELQFTLKL 550
SKYLEKTERI MKIYSEIADT PIEVINELKA QKDRLLDYIN RYGDKVSPFQ 600
LVKS 604
Length:604
Mass (Da):68,720
Last modified:August 2, 2005 - v1
Checksum:iFFEA81938BF49096
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000077 Genomic DNA. Translation: AAY80452.1.
RefSeqiYP_255745.1. NC_007181.1.

Genome annotation databases

EnsemblBacteriaiAAY80452; AAY80452; Saci_1100.
GeneIDi3474134.
KEGGisai:Saci_1100.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000077 Genomic DNA. Translation: AAY80452.1 .
RefSeqi YP_255745.1. NC_007181.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 330779.Saci_1100.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY80452 ; AAY80452 ; Saci_1100 .
GeneIDi 3474134.
KEGGi sai:Saci_1100.

Phylogenomic databases

eggNOGi COG1274.
HOGENOMi HOG000191700.
KOi K01596.
OMAi SEFLLYR.

Enzyme and pathway databases

UniPathwayi UPA00138 .
BioCyci SACI330779:GH9J-1081-MONOMER.

Family and domain databases

Gene3Di 3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPi MF_00452. PEPCK_GTP.
InterProi IPR013035. PEP_carboxykinase_C.
IPR008209. PEP_carboxykinase_GTP.
IPR008210. PEP_carboxykinase_N.
[Graphical view ]
PANTHERi PTHR11561. PTHR11561. 1 hit.
Pfami PF00821. PEPCK. 1 hit.
[Graphical view ]
PIRSFi PIRSF001348. PEP_carboxykinase_GTP. 1 hit.
SUPFAMi SSF68923. SSF68923. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome of Sulfolobus acidocaldarius, a model organism of the Crenarchaeota."
    Chen L., Bruegger K., Skovgaard M., Redder P., She Q., Torarinsson E., Greve B., Awayez M., Zibat A., Klenk H.-P., Garrett R.A.
    J. Bacteriol. 187:4992-4999(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770.

Entry informationi

Entry nameiPCKG_SULAC
AccessioniPrimary (citable) accession number: Q4J9S8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: August 2, 2005
Last modified: May 14, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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