ID   GLPK1_SULAC             Reviewed;         498 AA.
AC   Q4J9R1;
DT   27-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   16-JUN-2009, entry version 28.
DE   RecName: Full=Glycerol kinase 1;
DE            EC=2.7.1.30;
DE   AltName: Full=ATP:glycerol 3-phosphotransferase 1;
DE   AltName: Full=Glycerokinase 1;
DE            Short=GK 1;
GN   Name=glpK1; OrderedLocusNames=Saci_1117;
OS   Sulfolobus acidocaldarius.
OC   Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC   Sulfolobus.
OX   NCBI_TaxID=2285;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33909 / DSM 639 / IFO 15157 / JCM 8929 / NCIB 11770;
RX   PubMed=15995215; DOI=10.1128/JB.187.14.4992-4999.2005;
RA   Chen L., Bruegger K., Skovgaard M., Redder P., She Q., Torarinsson E.,
RA   Greve B., Awayez M., Zibat A., Klenk H.-P., Garrett R.A.;
RT   "The genome of Sulfolobus acidocaldarius, a model organism of the
RT   Crenarchaeota.";
RL   J. Bacteriol. 187:4992-4999(2005).
CC   -!- FUNCTION: Key enzyme in the regulation of glycerol uptake and
CC       metabolism.
CC   -!- CATALYTIC ACTIVITY: ATP + glycerol = ADP + sn-glycerol 3-
CC       phosphate.
CC   -!- PATHWAY: Polyol metabolism; glycerol degradation via glycerol
CC       kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.
CC   -!- SIMILARITY: Belongs to the FGGY kinase family.
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DR   EMBL; CP000077; AAY80469.1; -; Genomic_DNA.
DR   RefSeq; YP_255762.1; -.
DR   GeneID; 3474151; -.
DR   GenomeReviews; CP000077_GR; Saci_1117.
DR   KEGG; sai:Saci_1117; -.
DR   NMPDR; fig|330779.3.peg.1592; -.
DR   HOGENOM; Q4J9R1; -.
DR   OMA; Q4J9R1; GVSKNNL.
DR   BioCyc; SACI330779:SACI_1117-MON; -.
DR   BRENDA; 2.7.1.30; 434.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0004370; F:glycerol kinase activity; IEA:HAMAP.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   GO; GO:0006072; P:glycerol-3-phosphate metabolic process; IEA:HAMAP.
DR   HAMAP; MF_00186; -; 1.
DR   InterPro; IPR000577; Carb_kinase_FGGY.
DR   InterPro; IPR018485; Carb_kinase_FGGY_C.
DR   InterPro; IPR018483; Carb_kinase_FGGY_CS.
DR   InterPro; IPR018484; Carb_kinase_FGGY_N.
DR   InterPro; IPR005999; Glycerol_kin.
DR   PANTHER; PTHR10196; FGGY_kin; 1.
DR   PANTHER; PTHR10196:SF9; Glycerol_kin; 1.
DR   Pfam; PF02782; FGGY_C; 1.
DR   Pfam; PF00370; FGGY_N; 1.
DR   TIGRFAMs; TIGR01311; glycerol_kin; 1.
DR   PROSITE; PS00933; FGGY_KINASES_1; 1.
DR   PROSITE; PS00445; FGGY_KINASES_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Glycerol metabolism; Kinase;
KW   Nucleotide-binding; Transferase.
FT   CHAIN         1    498       Glycerol kinase 1.
FT                                /FTId=PRO_0000059531.
FT   NP_BIND     405    409       ATP (By similarity).
FT   BINDING      12     12       Substrate (By similarity).
FT   BINDING      16     16       ATP (By similarity).
FT   BINDING      82     82       Substrate (By similarity).
FT   BINDING     133    133       Substrate (By similarity).
FT   BINDING     239    239       Substrate (By similarity).
FT   BINDING     261    261       ATP (By similarity).
FT   BINDING     303    303       ATP; via carbonyl oxygen (By similarity).
SQ   SEQUENCE   498 AA;  55687 MW;  B30A41F5845CB983 CRC64;
     MSKYILAVDE GTTSARALVF DEDLNVISIA QTELTQYFPR PGYVEQNPEE IFEKQVSMIK
     KAVEKAKIEI SQVSAIGIAN QRETTIMWDS RSGRPVYNAV VWQDRRTSDI TDWLKSNYLN
     LFKSKTGLIP DPYFSASKIK WILDNVPGVR EKAERGEIKF GTVDTYLIWK LTNGKVHVTD
     YSNASRTMLF NIKKLEWDRD ILEILEIPEA ILPEVRSSSE VYGYAEPVGN IPISGDAGDQ
     QAALFGQLGF SKGDVKCTYG TGSFILMNSG EEIYDSKDLL TTIAWKIGKD VKYALEGSIF
     TTGAAVQWVR DGLGLVSSSD EIESLASSVV DNGGVYFVPA FSGLGSPYWD PYARGLIIGI
     SRGTSRGHIA RAVLESIAYQ VRDVIEVIKK DVGKEFVNVL KVDGGVSKNN LLMQFQADIL
     GIRIVRPRVI ETTSMGASML AGLAVDYWSS LEELKSKWAV DREFIPSLQE DRRERLYKGW
     KEAVRRTIGW AREVETME
//