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Q4J9R1 (GLPK1_SULAC) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glycerol kinase 1
EC=2.7.1.30
Alternative name(s):
ATP:glycerol 3-phosphotransferase 1
Glycerokinase 1
Short name=GK 1
Gene names
Name:glpK1
Ordered Locus Names:Saci_1117
OrganismSulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) [Complete proteome] [HAMAP]
Taxonomic identifier330779 [NCBI]
Taxonomic lineageArchaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus

Protein attributes

Sequence length498 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Key enzyme in the regulation of glycerol uptake and metabolism. HAMAP MF_00186

Catalytic activity

ATP + glycerol = ADP + sn-glycerol 3-phosphate. HAMAP MF_00186

Pathway

Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. HAMAP MF_00186

Sequence similarities

Belongs to the FGGY kinase family.

Ontologies

Keywords
   Biological processGlycerol metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processglycerol-3-phosphate metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

glycerol kinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 498498Glycerol kinase 1 HAMAP MF_00186
PRO_0000059531

Regions

Nucleotide binding405 – 4095ATP By similarity

Sites

Binding site121Substrate By similarity
Binding site161ATP By similarity
Binding site821Substrate By similarity
Binding site1331Substrate By similarity
Binding site2391Substrate By similarity
Binding site2611ATP By similarity
Binding site3031ATP; via carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4J9R1 [UniParc].

Last modified August 2, 2005. Version 1.
Checksum: B30A41F5845CB983

FASTA49855,687
        10         20         30         40         50         60 
MSKYILAVDE GTTSARALVF DEDLNVISIA QTELTQYFPR PGYVEQNPEE IFEKQVSMIK 

        70         80         90        100        110        120 
KAVEKAKIEI SQVSAIGIAN QRETTIMWDS RSGRPVYNAV VWQDRRTSDI TDWLKSNYLN 

       130        140        150        160        170        180 
LFKSKTGLIP DPYFSASKIK WILDNVPGVR EKAERGEIKF GTVDTYLIWK LTNGKVHVTD 

       190        200        210        220        230        240 
YSNASRTMLF NIKKLEWDRD ILEILEIPEA ILPEVRSSSE VYGYAEPVGN IPISGDAGDQ 

       250        260        270        280        290        300 
QAALFGQLGF SKGDVKCTYG TGSFILMNSG EEIYDSKDLL TTIAWKIGKD VKYALEGSIF 

       310        320        330        340        350        360 
TTGAAVQWVR DGLGLVSSSD EIESLASSVV DNGGVYFVPA FSGLGSPYWD PYARGLIIGI 

       370        380        390        400        410        420 
SRGTSRGHIA RAVLESIAYQ VRDVIEVIKK DVGKEFVNVL KVDGGVSKNN LLMQFQADIL 

       430        440        450        460        470        480 
GIRIVRPRVI ETTSMGASML AGLAVDYWSS LEELKSKWAV DREFIPSLQE DRRERLYKGW 

       490 
KEAVRRTIGW AREVETME

« Hide

References

[1]"The genome of Sulfolobus acidocaldarius, a model organism of the Crenarchaeota."
Chen L., Bruegger K., Skovgaard M., Redder P., She Q., Torarinsson E., Greve B., Awayez M., Zibat A., Klenk H.-P., Garrett R.A.
J. Bacteriol. 187:4992-4999(2005) [PubMed: 15995215] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000077 Genomic DNA. Translation: AAY80469.1.
RefSeqYP_255762.1. NC_007181.1.

3D structure databases

ProteinModelPortalQ4J9R1.
SMRQ4J9R1. Positions 1-496.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3474151.
GenomeReviewsGene locus Saci_1117 in contig CP000077_GR.
KEGGsai:Saci_1117.
NMPDRfig|330779.3.peg.1592.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG511469.
OMATINETTA.
PhylomeDBQ4J9R1.
ProtClustDBCLSK268256.

Enzyme and pathway databases

BioCycSACI330779:SACI_1117-MONOMER.

Family and domain databases

HAMAPMF_00186. Glycerol_kin.
[Tree]
InterProIPR000577. Carb_kinase_FGGY.
IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
KOK00864.
PANTHERPTHR10196. FGGY_kin. 1 hit.
PTHR10196:SF9. Glycerol_kin. 1 hit.
PfamPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR01311. Glycerol_kin. 1 hit.
PROSITEPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLPK1_SULAC
AccessionPrimary (citable) accession number: Q4J9R1
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: August 2, 2005
Last modified: December 14, 2011
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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