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Protein

Probable deoxyhypusine synthase

Gene

dys

Organism
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.UniRule annotation

Catalytic activityi

[eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine.UniRule annotation

Cofactori

NAD+UniRule annotation

Pathwayi: eIF5A hypusination

This protein is involved in the pathway eIF5A hypusination, which is part of Protein modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway eIF5A hypusination and in Protein modification.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei284 – 2841NucleophileUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Hypusine biosynthesis

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciSACI330779:GH9J-1294-MONOMER.
UniPathwayiUPA00354.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable deoxyhypusine synthaseUniRule annotation (EC:2.5.1.46UniRule annotation)
Short name:
DHSUniRule annotation
Gene namesi
Name:dysUniRule annotation
Ordered Locus Names:Saci_1316
OrganismiSulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Taxonomic identifieri330779 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001018 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 311311Probable deoxyhypusine synthasePRO_0000134507Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi330779.Saci_1316.

Structurei

3D structure databases

ProteinModelPortaliQ4J978.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the deoxyhypusine synthase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04142. Archaea.
COG1899. LUCA.
HOGENOMiHOG000228838.
KOiK00809.
OMAiTYEQMVF.

Family and domain databases

Gene3Di3.40.910.10. 1 hit.
HAMAPiMF_00153. DHS. 1 hit.
InterProiIPR022899. Deoxyhypus_synthase_arc.
IPR002773. Deoxyhypusine_synthase.
IPR029035. DHS-like_NAD/FAD-binding_dom.
[Graphical view]
PANTHERiPTHR11703. PTHR11703. 1 hit.
PfamiPF01916. DS. 1 hit.
[Graphical view]
SUPFAMiSSF52467. SSF52467. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4J978-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKREDLLTNV VDDLSLEDLR DLKNLEIIFD KVYGFSAENV VKAVEILRDL
60 70 80 90 100
IKEADLRFLS FTANLVSTGL RGLLADLIRR EYFNVVITTG GTIDHDIARS
110 120 130 140 150
FGGKYYKGSF EFDDTMLKEL EIHRLGNIFI PFENYGKVIE EVVRKYIPEI
160 170 180 190 200
VSVRKDWSVY ELLWEFGKRI NDQHSILKAC YEKKVPLIVP GVVDGSFGTN
210 220 230 240 250
LFIVSQFNGL KIDLFQDMRL IKDLIFSSEK SGALIIGGGI SKHHTIWWNQ
260 270 280 290 300
FKDGLDYAIY ITTAQEYDGS LSGARPREAI SWNKVRPSAR SVTIYADATI
310
ILPILSASLL R
Length:311
Mass (Da):35,399
Last modified:August 2, 2005 - v1
Checksum:i4CDAB561A726CDC0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000077 Genomic DNA. Translation: AAY80652.1.
RefSeqiWP_011278154.1. NC_007181.1.

Genome annotation databases

EnsemblBacteriaiAAY80652; AAY80652; Saci_1316.
GeneIDi3473393.
KEGGisai:Saci_1316.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000077 Genomic DNA. Translation: AAY80652.1.
RefSeqiWP_011278154.1. NC_007181.1.

3D structure databases

ProteinModelPortaliQ4J978.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi330779.Saci_1316.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAY80652; AAY80652; Saci_1316.
GeneIDi3473393.
KEGGisai:Saci_1316.

Phylogenomic databases

eggNOGiarCOG04142. Archaea.
COG1899. LUCA.
HOGENOMiHOG000228838.
KOiK00809.
OMAiTYEQMVF.

Enzyme and pathway databases

UniPathwayiUPA00354.
BioCyciSACI330779:GH9J-1294-MONOMER.

Family and domain databases

Gene3Di3.40.910.10. 1 hit.
HAMAPiMF_00153. DHS. 1 hit.
InterProiIPR022899. Deoxyhypus_synthase_arc.
IPR002773. Deoxyhypusine_synthase.
IPR029035. DHS-like_NAD/FAD-binding_dom.
[Graphical view]
PANTHERiPTHR11703. PTHR11703. 1 hit.
PfamiPF01916. DS. 1 hit.
[Graphical view]
SUPFAMiSSF52467. SSF52467. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDHYS_SULAC
AccessioniPrimary (citable) accession number: Q4J978
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: August 2, 2005
Last modified: September 7, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.