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Protein

Probable N-glycosylase/DNA lyase

Gene

ogg

Organism
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites).UniRule annotation

Catalytic activityi

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei128UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase, Lyase, Multifunctional enzyme
Biological processDNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
Probable N-glycosylase/DNA lyaseUniRule annotation
Including the following 2 domains:
8-oxoguanine DNA glycosylaseUniRule annotation (EC:3.2.2.-UniRule annotation)
DNA-(apurinic or apyrimidinic site) lyaseUniRule annotation (EC:4.2.99.18UniRule annotation)
Short name:
AP lyaseUniRule annotation
Gene namesi
Name:oggUniRule annotation
Ordered Locus Names:Saci_1367
OrganismiSulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Taxonomic identifieri330779 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001018 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001595651 – 203Probable N-glycosylase/DNA lyaseAdd BLAST203

Interactioni

Protein-protein interaction databases

STRINGi330779.Saci_1367

Structurei

3D structure databases

ProteinModelPortaliQ4J929
SMRiQ4J929
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the type-2 OGG1 family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04357 Archaea
COG1059 LUCA
HOGENOMiHOG000224507
KOiK03653
OMAiGYKEASH
OrthoDBiPOG093Z0AOL

Family and domain databases

CDDicd00056 ENDO3c, 1 hit
Gene3Di1.10.1670.10, 2 hits
HAMAPiMF_00241 Ogg, 1 hit
InterProiView protein in InterPro
IPR012092 DNA_glyclase/DNA_lyase_thermo
IPR011257 DNA_glycosylase
IPR003265 HhH-GPD_domain
IPR023170 HTH_base_excis_C
PIRSFiPIRSF005954 Thrmst_ogg, 1 hit
SMARTiView protein in SMART
SM00478 ENDO3c, 1 hit
SUPFAMiSSF48150 SSF48150, 1 hit

Sequencei

Sequence statusi: Complete.

Q4J929-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRSLVLNEK LRARVLERAE EFLLNNKADE EVWFRELVLC ILTSNSSFIS
60 70 80 90 100
AYKSMNYILD KILYMDEKEI SILLQESGYR FYNLKAKYLY RAKNLYGKVK
110 120 130 140 150
KTIKEIADKD QMQAREFIAT HIYGIGYKEA SHFLRNVGYL DLAIIDRHIL
160 170 180 190 200
RFINNLGIPI KLKSKREYLL AESLLRSIAN NLNVQVGLLD LFIFFKQTNT

IVK
Length:203
Mass (Da):23,869
Last modified:August 2, 2005 - v1
Checksum:i28AF6E867FC8D207
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000077 Genomic DNA Translation: AAY80701.1
RefSeqiWP_011278203.1, NC_007181.1

Genome annotation databases

EnsemblBacteriaiAAY80701; AAY80701; Saci_1367
GeneIDi3472932
KEGGisai:Saci_1367
PATRICifig|330779.12.peg.1319

Similar proteinsi

Entry informationi

Entry nameiOGG1_SULAC
AccessioniPrimary (citable) accession number: Q4J929
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: August 2, 2005
Last modified: May 23, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health