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Q4J929

- OGG1_SULAC

UniProt

Q4J929 - OGG1_SULAC

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Protein
Probable N-glycosylase/DNA lyase
Gene
ogg, Saci_1367
Organism
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites) By similarity.UniRule annotation

Catalytic activityi

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei128 – 1281 By similarity

GO - Molecular functioni

  1. DNA-(apurinic or apyrimidinic site) lyase activity Source: UniProtKB-HAMAP
  2. hydrolase activity, hydrolyzing N-glycosyl compounds Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. base-excision repair Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase, Lyase

Keywords - Biological processi

DNA damage, DNA repair

Enzyme and pathway databases

BioCyciSACI330779:GH9J-1345-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable N-glycosylase/DNA lyase
Including the following 2 domains:
8-oxoguanine DNA glycosylase (EC:3.2.2.-)
DNA-(apurinic or apyrimidinic site) lyase (EC:4.2.99.18)
Short name:
AP lyase
Gene namesi
Name:ogg
Ordered Locus Names:Saci_1367
OrganismiSulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Taxonomic identifieri330779 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000001018: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 203203Probable N-glycosylase/DNA lyaseUniRule annotation
PRO_0000159565Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi330779.Saci_1367.

Structurei

3D structure databases

ProteinModelPortaliQ4J929.

Family & Domainsi

Sequence similaritiesi

Belongs to the type-2 OGG1 family.

Phylogenomic databases

eggNOGiCOG1059.
HOGENOMiHOG000224507.
KOiK03653.
OMAiLDLYLWY.

Family and domain databases

Gene3Di1.10.340.30. 1 hit.
HAMAPiMF_00241. Ogg.
InterProiIPR012092. DNA_glyclase/DNA_lyase_thermo.
IPR011257. DNA_glycosylase.
IPR003265. HhH-GPD_domain.
[Graphical view]
PfamiPF00730. HhH-GPD. 1 hit.
[Graphical view]
PIRSFiPIRSF005954. Thrmst_ogg. 1 hit.
SMARTiSM00478. ENDO3c. 1 hit.
[Graphical view]
SUPFAMiSSF48150. SSF48150. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4J929-1 [UniParc]FASTAAdd to Basket

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MLRSLVLNEK LRARVLERAE EFLLNNKADE EVWFRELVLC ILTSNSSFIS    50
AYKSMNYILD KILYMDEKEI SILLQESGYR FYNLKAKYLY RAKNLYGKVK 100
KTIKEIADKD QMQAREFIAT HIYGIGYKEA SHFLRNVGYL DLAIIDRHIL 150
RFINNLGIPI KLKSKREYLL AESLLRSIAN NLNVQVGLLD LFIFFKQTNT 200
IVK 203
Length:203
Mass (Da):23,869
Last modified:August 2, 2005 - v1
Checksum:i28AF6E867FC8D207
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000077 Genomic DNA. Translation: AAY80701.1.
RefSeqiYP_255994.1. NC_007181.1.

Genome annotation databases

EnsemblBacteriaiAAY80701; AAY80701; Saci_1367.
GeneIDi3472932.
KEGGisai:Saci_1367.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000077 Genomic DNA. Translation: AAY80701.1 .
RefSeqi YP_255994.1. NC_007181.1.

3D structure databases

ProteinModelPortali Q4J929.
ModBasei Search...

Protein-protein interaction databases

STRINGi 330779.Saci_1367.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY80701 ; AAY80701 ; Saci_1367 .
GeneIDi 3472932.
KEGGi sai:Saci_1367.

Phylogenomic databases

eggNOGi COG1059.
HOGENOMi HOG000224507.
KOi K03653.
OMAi LDLYLWY.

Enzyme and pathway databases

BioCyci SACI330779:GH9J-1345-MONOMER.

Family and domain databases

Gene3Di 1.10.340.30. 1 hit.
HAMAPi MF_00241. Ogg.
InterProi IPR012092. DNA_glyclase/DNA_lyase_thermo.
IPR011257. DNA_glycosylase.
IPR003265. HhH-GPD_domain.
[Graphical view ]
Pfami PF00730. HhH-GPD. 1 hit.
[Graphical view ]
PIRSFi PIRSF005954. Thrmst_ogg. 1 hit.
SMARTi SM00478. ENDO3c. 1 hit.
[Graphical view ]
SUPFAMi SSF48150. SSF48150. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome of Sulfolobus acidocaldarius, a model organism of the Crenarchaeota."
    Chen L., Bruegger K., Skovgaard M., Redder P., She Q., Torarinsson E., Greve B., Awayez M., Zibat A., Klenk H.-P., Garrett R.A.
    J. Bacteriol. 187:4992-4999(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770.

Entry informationi

Entry nameiOGG1_SULAC
AccessioniPrimary (citable) accession number: Q4J929
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: August 2, 2005
Last modified: May 14, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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