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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:Saci_1519
OrganismiSulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Taxonomic identifieri330779 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001197301 – 567Glutamate--tRNA ligaseAdd BLAST567

Proteomic databases

PRIDEiQ4J8P2

Interactioni

Protein-protein interaction databases

STRINGi330779.Saci_1519

Structurei

3D structure databases

ProteinModelPortaliQ4J8P2
SMRiQ4J8P2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi106 – 116"HIGH" regionUniRule annotationAdd BLAST11

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04302 Archaea
COG0008 LUCA
HOGENOMiHOG000073585
KOiK01885
OMAiMRFAPNP
OrthoDBiPOG093Z013J

Family and domain databases

Gene3Di2.40.240.10, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_02076 Glu_tRNA_synth_type2, 1 hit
InterProiView protein in InterPro
IPR004526 Glu-tRNA-synth_arc/euk
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR020059 Glu/Gln-tRNA-synth_Ib_codon-bd
IPR020056 Rbsml_L25/Gln-tRNA_synth_N
IPR011035 Ribosomal_L25/Gln-tRNA_synth
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PF03950 tRNA-synt_1c_C, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF50715 SSF50715, 1 hit
TIGRFAMsiTIGR00463 gltX_arch, 1 hit

Sequencei

Sequence statusi: Complete.

Q4J8P2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDDIRNLVY KYALHNAYTH NGKANVNAVV SKIFAERPEL RSKAKDIVEI
60 70 80 90 100
AKELVNYVNS LDVESQKKEL ESKFPEMLEE KKREKESKKE LPDIPVSGVL
110 120 130 140 150
VTRFAPNPDG PLHLGNARAA IISHEYARIY NGKFILRFDD TDPKTKKPIP
160 170 180 190 200
EAYDWIKEDL KWLGIKWDLE VRASARLETY YNFARILLSK GYAYIDLCKE
210 220 230 240 250
AEFKERRSKR EACPHRETSP ESNLELFEKM IHGEFEEGKA VVRLKTDLKL
260 270 280 290 300
PDPSQRDWVL LRVINVKKSP HPIEGDKYWV WPTYNFASAI DDYDLGVTHI
310 320 330 340 350
FRGKEHAVNA EKQKWIYNYM GWKYPYVREF GRLKLEGFMM SKSKIRTVVE
360 370 380 390 400
KGVGIDDPRL PTLAGLRRRG ILSDTIKEII ITVGLKETDA TISFDNLAST
410 420 430 440 450
NRKKLDKIAK RLMFVGSPKE FIIDIPQPIL AKIPYHPSNP NEYREISVNP
460 470 480 490 500
GDIILINEND AKDKVLRLME LCNVTVNGDK LVYNSKGIED AKKLGMKIIQ
510 520 530 540 550
WVKKDESVPV VVLSPDPEKG IETINGVGES EIRNLNKGEI VQFIRYGFVK
560
VDEKSADGQV TVIFSHE
Length:567
Mass (Da):65,094
Last modified:August 2, 2005 - v1
Checksum:iBECBD7A495395D94
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000077 Genomic DNA Translation: AAY80838.1
RefSeqiWP_011278340.1, NC_007181.1

Genome annotation databases

EnsemblBacteriaiAAY80838; AAY80838; Saci_1519
GeneIDi3474643
KEGGisai:Saci_1519
PATRICifig|330779.12.peg.1463

Entry informationi

Entry nameiSYE_SULAC
AccessioniPrimary (citable) accession number: Q4J8P2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: August 2, 2005
Last modified: May 23, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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