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Q4J8J7

- SYL2_SULAC

UniProt

Q4J8J7 - SYL2_SULAC

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Protein

Leucine--tRNA ligase 2

Gene
leuS2, Saci_1572
Organism
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei622 – 6221ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSACI330779:GH9J-1544-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase 2 (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase 2
Short name:
LeuRS 2
Gene namesi
Name:leuS2
Ordered Locus Names:Saci_1572
OrganismiSulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Taxonomic identifieri330779 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000001018: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 942942Leucine--tRNA ligase 2UniRule annotationPRO_0000152143Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi330779.Saci_1572.

Structurei

3D structure databases

ProteinModelPortaliQ4J8J7.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi35 – 4511"HIGH" regionUniRule annotationAdd
BLAST
Motifi619 – 6235"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000216620.
KOiK01869.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_A. Leu_tRNA_synth_A.
InterProiIPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsiTIGR00395. leuS_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4J8J7-1 [UniParc]FASTAAdd to Basket

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MKISEKWQKE WENKRVFDAT PDPNKKKFFT TIAFPYPNSP FHLGHGRTYV    50
TGDIYARYMR MRGYNVLFPM AFHYTGTPII AMADDVAKGD KELIDIFKSI 100
YEIPDDVISK LVDPLFMANY FKEEIKQAMK EIGLSIDWRR EFTTIDPEFS 150
SFIIWQFRKL QEKGFIVRDT HPVGWCPVHH IPVGMHDTKG DMEPEIGEFV 200
LIYFDSDMGI LPVATLRPET VFGAIAVWVN PHESYSIVEI DGKKYVMSEK 250
ASSKLSFQID NLKVITVVKG SELVKHSAVN PITGKEVPII GANFVDPLTG 300
TGVVMSVPAH APFDYFYLKK TKSELSIISV IRVEGMGETL AKDLVEKSNP 350
QNDNDLKKLT EQVYRIEYNK GVMIDITKLV KPEYVEELKP LVNLPVPAAR 400
QKITEFITQK GLGRKIYEIM NRPVYCRCGN EVVVKILKDQ WFLDYGNQEW 450
KDLARKSIES IRFIPPEIKK DFEFVVDWLQ KRACARTRGL GTPLPWDKKW 500
IIESLSDSTI YMAFYTIAHR LKEHKLKPSQ LTYEFWEYIM LGNGNPDEIS 550
KISGIPVEVI KAMRDEFLYW YPLDVRHSGK DLVPNHLSFF IFNHAAIFPH 600
QLWPKGIAVN GFVLYDGKKM SKSLRNIVPL RKAIRMYSPD VIRIALTTNA 650
DIGSDVNFSD SYAKSIIDTL KNYYDLLEKL KEFKGEDEGF PEKWLKSKFY 700
QMVINVTQYM DSLDLRSSSN EILYNFSSYI NEYFELVRSE GREPNGKLLS 750
QILQIWIKLL SPFAPHFAEE LWHKIGKNTL VSLESWPIID QSNVDLFIDL 800
THTYHRKLLN DIQAILSVYK DTPKSIKIFV ANKEFLNVLR DAINIVQKGG 850
QLRQLMEIHK PKGKQDARLY QKIYEEAREI DDDMKKLVTN FDFDEKDLLD 900
KGLKYLSYKL GIKEIRILDA SEMDRTKYNK DALPLRPAII IE 942
Length:942
Mass (Da):109,179
Last modified:September 27, 2005 - v2
Checksum:i4DD802C8C8C861C4
GO

Sequence cautioni

The sequence AAY80885.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000077 Genomic DNA. Translation: AAY80885.1. Different initiation.
RefSeqiYP_256178.1. NC_007181.1.

Genome annotation databases

EnsemblBacteriaiAAY80885; AAY80885; Saci_1572.
GeneIDi3474607.
KEGGisai:Saci_1572.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000077 Genomic DNA. Translation: AAY80885.1 . Different initiation.
RefSeqi YP_256178.1. NC_007181.1.

3D structure databases

ProteinModelPortali Q4J8J7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 330779.Saci_1572.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY80885 ; AAY80885 ; Saci_1572 .
GeneIDi 3474607.
KEGGi sai:Saci_1572.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000216620.
KOi K01869.

Enzyme and pathway databases

BioCyci SACI330779:GH9J-1544-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_A. Leu_tRNA_synth_A.
InterProi IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsi TIGR00395. leuS_arch. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome of Sulfolobus acidocaldarius, a model organism of the Crenarchaeota."
    Chen L., Bruegger K., Skovgaard M., Redder P., She Q., Torarinsson E., Greve B., Awayez M., Zibat A., Klenk H.-P., Garrett R.A.
    J. Bacteriol. 187:4992-4999(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770.

Entry informationi

Entry nameiSYL2_SULAC
AccessioniPrimary (citable) accession number: Q4J8J7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: September 27, 2005
Last modified: May 14, 2014
This is version 60 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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