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Q4J8J7

- SYL2_SULAC

UniProt

Q4J8J7 - SYL2_SULAC

Protein

Leucine--tRNA ligase 2

Gene

leuS2

Organism
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 2 (27 Sep 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei622 – 6221ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSACI330779:GH9J-1544-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligase 2UniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetase 2UniRule annotation
    Short name:
    LeuRS 2UniRule annotation
    Gene namesi
    Name:leuS2UniRule annotation
    Ordered Locus Names:Saci_1572
    OrganismiSulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
    Taxonomic identifieri330779 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
    ProteomesiUP000001018: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 942942Leucine--tRNA ligase 2PRO_0000152143Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi330779.Saci_1572.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4J8J7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi35 – 4511"HIGH" regionAdd
    BLAST
    Motifi619 – 6235"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000216620.
    KOiK01869.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_A. Leu_tRNA_synth_A.
    InterProiIPR002300. aa-tRNA-synth_Ia.
    IPR020791. Leu-tRNA-lgase_arc.
    IPR004493. Leu-tRNA-synth_Ia_arc/euk.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 2 hits.
    TIGRFAMsiTIGR00395. leuS_arch. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q4J8J7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKISEKWQKE WENKRVFDAT PDPNKKKFFT TIAFPYPNSP FHLGHGRTYV    50
    TGDIYARYMR MRGYNVLFPM AFHYTGTPII AMADDVAKGD KELIDIFKSI 100
    YEIPDDVISK LVDPLFMANY FKEEIKQAMK EIGLSIDWRR EFTTIDPEFS 150
    SFIIWQFRKL QEKGFIVRDT HPVGWCPVHH IPVGMHDTKG DMEPEIGEFV 200
    LIYFDSDMGI LPVATLRPET VFGAIAVWVN PHESYSIVEI DGKKYVMSEK 250
    ASSKLSFQID NLKVITVVKG SELVKHSAVN PITGKEVPII GANFVDPLTG 300
    TGVVMSVPAH APFDYFYLKK TKSELSIISV IRVEGMGETL AKDLVEKSNP 350
    QNDNDLKKLT EQVYRIEYNK GVMIDITKLV KPEYVEELKP LVNLPVPAAR 400
    QKITEFITQK GLGRKIYEIM NRPVYCRCGN EVVVKILKDQ WFLDYGNQEW 450
    KDLARKSIES IRFIPPEIKK DFEFVVDWLQ KRACARTRGL GTPLPWDKKW 500
    IIESLSDSTI YMAFYTIAHR LKEHKLKPSQ LTYEFWEYIM LGNGNPDEIS 550
    KISGIPVEVI KAMRDEFLYW YPLDVRHSGK DLVPNHLSFF IFNHAAIFPH 600
    QLWPKGIAVN GFVLYDGKKM SKSLRNIVPL RKAIRMYSPD VIRIALTTNA 650
    DIGSDVNFSD SYAKSIIDTL KNYYDLLEKL KEFKGEDEGF PEKWLKSKFY 700
    QMVINVTQYM DSLDLRSSSN EILYNFSSYI NEYFELVRSE GREPNGKLLS 750
    QILQIWIKLL SPFAPHFAEE LWHKIGKNTL VSLESWPIID QSNVDLFIDL 800
    THTYHRKLLN DIQAILSVYK DTPKSIKIFV ANKEFLNVLR DAINIVQKGG 850
    QLRQLMEIHK PKGKQDARLY QKIYEEAREI DDDMKKLVTN FDFDEKDLLD 900
    KGLKYLSYKL GIKEIRILDA SEMDRTKYNK DALPLRPAII IE 942
    Length:942
    Mass (Da):109,179
    Last modified:September 27, 2005 - v2
    Checksum:i4DD802C8C8C861C4
    GO

    Sequence cautioni

    The sequence AAY80885.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000077 Genomic DNA. Translation: AAY80885.1. Different initiation.
    RefSeqiYP_256178.1. NC_007181.1.

    Genome annotation databases

    EnsemblBacteriaiAAY80885; AAY80885; Saci_1572.
    GeneIDi3474607.
    KEGGisai:Saci_1572.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000077 Genomic DNA. Translation: AAY80885.1 . Different initiation.
    RefSeqi YP_256178.1. NC_007181.1.

    3D structure databases

    ProteinModelPortali Q4J8J7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 330779.Saci_1572.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAY80885 ; AAY80885 ; Saci_1572 .
    GeneIDi 3474607.
    KEGGi sai:Saci_1572.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000216620.
    KOi K01869.

    Enzyme and pathway databases

    BioCyci SACI330779:GH9J-1544-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_A. Leu_tRNA_synth_A.
    InterProi IPR002300. aa-tRNA-synth_Ia.
    IPR020791. Leu-tRNA-lgase_arc.
    IPR004493. Leu-tRNA-synth_Ia_arc/euk.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 2 hits.
    TIGRFAMsi TIGR00395. leuS_arch. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome of Sulfolobus acidocaldarius, a model organism of the Crenarchaeota."
      Chen L., Bruegger K., Skovgaard M., Redder P., She Q., Torarinsson E., Greve B., Awayez M., Zibat A., Klenk H.-P., Garrett R.A.
      J. Bacteriol. 187:4992-4999(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770.

    Entry informationi

    Entry nameiSYL2_SULAC
    AccessioniPrimary (citable) accession number: Q4J8J7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2005
    Last sequence update: September 27, 2005
    Last modified: October 1, 2014
    This is version 61 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3