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Protein

Leucine--tRNA ligase 2

Gene

leuS2

Organism
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei622 – 6221ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSACI330779:GH9J-1544-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase 2UniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetase 2UniRule annotation
Short name:
LeuRS 2UniRule annotation
Gene namesi
Name:leuS2UniRule annotation
Ordered Locus Names:Saci_1572
OrganismiSulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Taxonomic identifieri330779 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000001018 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 942942Leucine--tRNA ligase 2PRO_0000152143Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi330779.Saci_1572.

Structurei

3D structure databases

ProteinModelPortaliQ4J8J7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi35 – 4511"HIGH" regionAdd
BLAST
Motifi619 – 6235"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000216620.
KOiK01869.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_A. Leu_tRNA_synth_A.
InterProiIPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsiTIGR00395. leuS_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4J8J7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKISEKWQKE WENKRVFDAT PDPNKKKFFT TIAFPYPNSP FHLGHGRTYV
60 70 80 90 100
TGDIYARYMR MRGYNVLFPM AFHYTGTPII AMADDVAKGD KELIDIFKSI
110 120 130 140 150
YEIPDDVISK LVDPLFMANY FKEEIKQAMK EIGLSIDWRR EFTTIDPEFS
160 170 180 190 200
SFIIWQFRKL QEKGFIVRDT HPVGWCPVHH IPVGMHDTKG DMEPEIGEFV
210 220 230 240 250
LIYFDSDMGI LPVATLRPET VFGAIAVWVN PHESYSIVEI DGKKYVMSEK
260 270 280 290 300
ASSKLSFQID NLKVITVVKG SELVKHSAVN PITGKEVPII GANFVDPLTG
310 320 330 340 350
TGVVMSVPAH APFDYFYLKK TKSELSIISV IRVEGMGETL AKDLVEKSNP
360 370 380 390 400
QNDNDLKKLT EQVYRIEYNK GVMIDITKLV KPEYVEELKP LVNLPVPAAR
410 420 430 440 450
QKITEFITQK GLGRKIYEIM NRPVYCRCGN EVVVKILKDQ WFLDYGNQEW
460 470 480 490 500
KDLARKSIES IRFIPPEIKK DFEFVVDWLQ KRACARTRGL GTPLPWDKKW
510 520 530 540 550
IIESLSDSTI YMAFYTIAHR LKEHKLKPSQ LTYEFWEYIM LGNGNPDEIS
560 570 580 590 600
KISGIPVEVI KAMRDEFLYW YPLDVRHSGK DLVPNHLSFF IFNHAAIFPH
610 620 630 640 650
QLWPKGIAVN GFVLYDGKKM SKSLRNIVPL RKAIRMYSPD VIRIALTTNA
660 670 680 690 700
DIGSDVNFSD SYAKSIIDTL KNYYDLLEKL KEFKGEDEGF PEKWLKSKFY
710 720 730 740 750
QMVINVTQYM DSLDLRSSSN EILYNFSSYI NEYFELVRSE GREPNGKLLS
760 770 780 790 800
QILQIWIKLL SPFAPHFAEE LWHKIGKNTL VSLESWPIID QSNVDLFIDL
810 820 830 840 850
THTYHRKLLN DIQAILSVYK DTPKSIKIFV ANKEFLNVLR DAINIVQKGG
860 870 880 890 900
QLRQLMEIHK PKGKQDARLY QKIYEEAREI DDDMKKLVTN FDFDEKDLLD
910 920 930 940
KGLKYLSYKL GIKEIRILDA SEMDRTKYNK DALPLRPAII IE
Length:942
Mass (Da):109,179
Last modified:September 27, 2005 - v2
Checksum:i4DD802C8C8C861C4
GO

Sequence cautioni

The sequence AAY80885.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000077 Genomic DNA. Translation: AAY80885.1. Different initiation.
RefSeqiYP_256178.1. NC_007181.1.

Genome annotation databases

EnsemblBacteriaiAAY80885; AAY80885; Saci_1572.
GeneIDi3474607.
KEGGisai:Saci_1572.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000077 Genomic DNA. Translation: AAY80885.1. Different initiation.
RefSeqiYP_256178.1. NC_007181.1.

3D structure databases

ProteinModelPortaliQ4J8J7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi330779.Saci_1572.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAY80885; AAY80885; Saci_1572.
GeneIDi3474607.
KEGGisai:Saci_1572.

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000216620.
KOiK01869.

Enzyme and pathway databases

BioCyciSACI330779:GH9J-1544-MONOMER.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_A. Leu_tRNA_synth_A.
InterProiIPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsiTIGR00395. leuS_arch. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The genome of Sulfolobus acidocaldarius, a model organism of the Crenarchaeota."
    Chen L., Bruegger K., Skovgaard M., Redder P., She Q., Torarinsson E., Greve B., Awayez M., Zibat A., Klenk H.-P., Garrett R.A.
    J. Bacteriol. 187:4992-4999(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770.

Entry informationi

Entry nameiSYL2_SULAC
AccessioniPrimary (citable) accession number: Q4J8J7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: September 27, 2005
Last modified: January 7, 2015
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.