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Q4J8I8

- HISX_SULAC

UniProt

Q4J8I8 - HISX_SULAC

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Protein

Histidinol dehydrogenase

Gene
hisD, Saci_1579
Organism
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei112 – 1121NAD By similarity
Binding sitei171 – 1711NAD By similarity
Binding sitei194 – 1941NAD By similarity
Binding sitei217 – 2171Substrate By similarity
Metal bindingi239 – 2391Zinc By similarity
Binding sitei239 – 2391Substrate By similarity
Metal bindingi242 – 2421Zinc By similarity
Binding sitei242 – 2421Substrate By similarity
Active sitei293 – 2931Proton acceptor By similarity
Active sitei294 – 2941Proton acceptor By similarity
Binding sitei294 – 2941Substrate By similarity
Metal bindingi326 – 3261Zinc By similarity
Binding sitei326 – 3261Substrate By similarity
Binding sitei379 – 3791Substrate By similarity
Metal bindingi384 – 3841Zinc By similarity
Binding sitei384 – 3841Substrate By similarity

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciSACI330779:GH9J-1551-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:Saci_1579
OrganismiSulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Taxonomic identifieri330779 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000001018: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 393393Histidinol dehydrogenaseUniRule annotationPRO_0000135905Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi330779.Saci_1579.

Structurei

3D structure databases

ProteinModelPortaliQ4J8I8.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiFQEITRE.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4J8I8-1 [UniParc]FASTAAdd to Basket

« Hide

MIKYEIPKSR PNEFSKVLPL VEQILNQVKE RGDKALLELE EKYDKAKLDS    50
LVENRIDELA SKIPEEYKAA IDRIYDQLVE FHKTTLPYMV GGGYNGIEFG 100
ILWRAIEKVG IYVPGGLKSY PSTLLMAAIP ARVAGVSEIY VATPPNRIDS 150
VIAYIAKKLK INALYRIGGA QAIAALAYGT ESVKKVDKIV GPGNIFVQAS 200
KFLVSKDVAI DGIEGPTELV VIADSSADYR HVILDMRAQA EHGSTSYIIL 250
VTTSDFLIDK VREELDKEEF TYYIVKVKSI DEAIDVANDI APEHLSLFVN 300
DPKSYLHKIK NAGAISLGKT PPALIDYAAG PDHILPTNAW SRVRGGLTVY 350
DFLKPISYAN SVNPDKELVN MAKLIAEYEG FIYHSKSIGA RYE 393
Length:393
Mass (Da):43,528
Last modified:August 2, 2005 - v1
Checksum:i1BD29F2FC3182EB5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000077 Genomic DNA. Translation: AAY80892.1.
RefSeqiYP_256185.1. NC_007181.1.

Genome annotation databases

EnsemblBacteriaiAAY80892; AAY80892; Saci_1579.
GeneIDi3474262.
KEGGisai:Saci_1579.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000077 Genomic DNA. Translation: AAY80892.1 .
RefSeqi YP_256185.1. NC_007181.1.

3D structure databases

ProteinModelPortali Q4J8I8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 330779.Saci_1579.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY80892 ; AAY80892 ; Saci_1579 .
GeneIDi 3474262.
KEGGi sai:Saci_1579.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi FQEITRE.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci SACI330779:GH9J-1551-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of Sulfolobus acidocaldarius, a model organism of the Crenarchaeota."
    Chen L., Bruegger K., Skovgaard M., Redder P., She Q., Torarinsson E., Greve B., Awayez M., Zibat A., Klenk H.-P., Garrett R.A.
    J. Bacteriol. 187:4992-4999(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770.

Entry informationi

Entry nameiHISX_SULAC
AccessioniPrimary (citable) accession number: Q4J8I8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: August 2, 2005
Last modified: May 14, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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