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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: L-histidine biosynthesis

This protein is involved in step 9 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG)
  2. Phosphoribosyl-ATP pyrophosphatase (hisE)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. Imidazole glycerol phosphate synthase subunit HisF (hisF), Imidazole glycerol phosphate synthase subunit HisH (hisH)
  6. Imidazoleglycerol-phosphate dehydratase (hisB)
  7. no protein annotated in this organism
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei112NADUniRule annotation1
Binding sitei171NADUniRule annotation1
Binding sitei194NADUniRule annotation1
Binding sitei217SubstrateUniRule annotation1
Metal bindingi239ZincUniRule annotation1
Binding sitei239SubstrateUniRule annotation1
Metal bindingi242ZincUniRule annotation1
Binding sitei242SubstrateUniRule annotation1
Active sitei293Proton acceptorUniRule annotation1
Active sitei294Proton acceptorUniRule annotation1
Binding sitei294SubstrateUniRule annotation1
Metal bindingi326ZincUniRule annotation1
Binding sitei326SubstrateUniRule annotation1
Binding sitei379SubstrateUniRule annotation1
Metal bindingi384ZincUniRule annotation1
Binding sitei384SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAmino-acid biosynthesis, Histidine biosynthesis
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:Saci_1579
OrganismiSulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Taxonomic identifieri330779 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001018 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001359051 – 393Histidinol dehydrogenaseAdd BLAST393

Proteomic databases

PRIDEiQ4J8I8

Interactioni

Protein-protein interaction databases

STRINGi330779.Saci_1579

Structurei

3D structure databases

ProteinModelPortaliQ4J8I8
SMRiQ4J8I8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04352 Archaea
COG0141 LUCA
HOGENOMiHOG000243914
KOiK00013
OMAiQAEHDPM
OrthoDBiPOG093Z04GH

Family and domain databases

CDDicd06572 Histidinol_dh, 1 hit
HAMAPiMF_01024 HisD, 1 hit
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR001692 Histidinol_DH_CS
IPR022695 Histidinol_DH_monofunct
IPR012131 Hstdl_DH
PANTHERiPTHR21256 PTHR21256, 1 hit
PfamiView protein in Pfam
PF00815 Histidinol_dh, 1 hit
PIRSFiPIRSF000099 Histidinol_dh, 1 hit
PRINTSiPR00083 HOLDHDRGNASE
SUPFAMiSSF53720 SSF53720, 1 hit
TIGRFAMsiTIGR00069 hisD, 1 hit
PROSITEiView protein in PROSITE
PS00611 HISOL_DEHYDROGENASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q4J8I8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKYEIPKSR PNEFSKVLPL VEQILNQVKE RGDKALLELE EKYDKAKLDS
60 70 80 90 100
LVENRIDELA SKIPEEYKAA IDRIYDQLVE FHKTTLPYMV GGGYNGIEFG
110 120 130 140 150
ILWRAIEKVG IYVPGGLKSY PSTLLMAAIP ARVAGVSEIY VATPPNRIDS
160 170 180 190 200
VIAYIAKKLK INALYRIGGA QAIAALAYGT ESVKKVDKIV GPGNIFVQAS
210 220 230 240 250
KFLVSKDVAI DGIEGPTELV VIADSSADYR HVILDMRAQA EHGSTSYIIL
260 270 280 290 300
VTTSDFLIDK VREELDKEEF TYYIVKVKSI DEAIDVANDI APEHLSLFVN
310 320 330 340 350
DPKSYLHKIK NAGAISLGKT PPALIDYAAG PDHILPTNAW SRVRGGLTVY
360 370 380 390
DFLKPISYAN SVNPDKELVN MAKLIAEYEG FIYHSKSIGA RYE
Length:393
Mass (Da):43,528
Last modified:August 2, 2005 - v1
Checksum:i1BD29F2FC3182EB5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000077 Genomic DNA Translation: AAY80892.1
RefSeqiWP_011278394.1, NC_007181.1

Genome annotation databases

EnsemblBacteriaiAAY80892; AAY80892; Saci_1579
GeneIDi3474262
KEGGisai:Saci_1579
PATRICifig|330779.12.peg.1519

Similar proteinsi

Entry informationi

Entry nameiHISX_SULAC
AccessioniPrimary (citable) accession number: Q4J8I8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: August 2, 2005
Last modified: May 23, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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