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Q4J8F7 (Q4J8F7_SULAC) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Amidophosphoribosyltransferase PIRNR PIRNR000485
Short name=ATase PIRNR PIRNR000485
EC=2.4.2.14 PIRNR PIRNR000485
Alternative name(s):
Glutamine phosphoribosylpyrophosphate amidotransferase PIRNR PIRNR000485
Gene names
Name:purF-1 EMBL AAY80923.1
Ordered Locus Names:Saci_1611
OrganismSulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) [Complete proteome] [HAMAP] EMBL AAY80923.1
Taxonomic identifier330779 [NCBI]
Taxonomic lineageArchaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus

Protein attributes

Sequence length444 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O. PIRNR PIRNR000485

Cofactor

Binds 1 4Fe-4S cluster per subunit By similarity. PIRSR PIRSR000485-3

Binds 1 magnesium ion per subunit By similarity. PIRNR PIRNR000485

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2. PIRNR PIRNR000485

Sequence similarities

In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. PIRNR PIRNR000485

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site91For GATase activity By similarity PIRSR PIRSR000485-1
Metal binding2241Iron-sulfur (4Fe-4S) By similarity PIRSR PIRSR000485-3
Metal binding3701Iron-sulfur (4Fe-4S) By similarity PIRSR PIRSR000485-3
Metal binding4191Iron-sulfur (4Fe-4S) By similarity PIRSR PIRSR000485-3
Metal binding4221Iron-sulfur (4Fe-4S) By similarity PIRSR PIRSR000485-3

Sequences

Sequence LengthMass (Da)Tools
Q4J8F7 [UniParc].

Last modified August 2, 2005. Version 1.
Checksum: AD63D5CC708CB7F3

FASTA44449,229
        10         20         30         40         50         60 
MISKIKEHCG IVGIHNVPDA PRIVYETLKF LQHRGQESAG ITFLDKDRLS TVKGLGLVED 

        70         80         90        100        110        120 
ALDPIILKSS NFSIGHVRYS TTGRGVIDEA QPLSDGKIAL AFNGTIPNYI NYNVRIDTEF 

       130        140        150        160        170        180 
IYEVLKNQED IRQGIRKLVD VADGGYSLVV LTNKGELIGL RDPKGFRPLV LGKLGSGYII 

       190        200        210        220        230        240 
ASEDSAIRQL GGIVIRDVKP GEMIYIKNGS IESEIVARDE VHFCSFEYIY FSRADSIIDG 

       250        260        270        280        290        300 
VSVYRARVRL GEILAENHPA KADIVVPVPE SSVPIALGFS RKSGIPLEYG LVRTSVSKRS 

       310        320        330        340        350        360 
FIMPSQDKRE SIVEEKFGVV GEVVRNKKII LIDDSIVRGT TMKKLVKLIR ENGASEIHVR 

       370        380        390        400        410        420 
IGSPMIRYPC YMGIDFPNKK ELIANDKNEM EIAKSIGADS VEYLSIDEMI KAIGRQDLCH 

       430        440 
ACFSGMYPLK HSYDFSKLSV SMKG

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References

[1]"The genome of Sulfolobus acidocaldarius, a model organism of the Crenarchaeota."
Chen L., Bruegger K., Skovgaard M., Redder P., She Q., Torarinsson E., Greve B., Awayez M., Zibat A., Klenk H.-P., Garrett R.A.
J. Bacteriol. 187:4992-4999(2005) [PubMed: 15995215] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 33909 / DSM 639 / IFO 15157 / JCM 8929 / NCIB 11770 and ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000077 Genomic DNA. Translation: AAY80923.1.
RefSeqYP_256216.1. NC_007181.1.

3D structure databases

ProteinModelPortalQ4J8F7.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3474293.
GenomeReviewsGene locus Saci_1611 in contig CP000077_GR.
KEGGsai:Saci_1611.
NMPDRfig|330779.3.peg.527.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG392416.
OMAVWAPGEE.
PhylomeDBQ4J8F7.
ProtClustDBCLSK802804.

Enzyme and pathway databases

BioCycSACI330779:SACI_1611-MONOMER.

Family and domain databases

InterProIPR005854. Amd_phspho_trans.
IPR000583. GATase_2.
IPR017932. GATase_II.
IPR000836. PRibTrfase.
[Graphical view]
KOK00764.
PANTHERPTHR11907. Amd_phspho_trans. 1 hit.
PfamPF00310. GATase_2. 1 hit.
PF00156. Pribosyltran. 1 hit.
[Graphical view]
PIRSFPIRSF000485. Amd_phspho_trans. 1 hit.
TIGRFAMsTIGR01134. PurF. 1 hit.
PROSITEPS51278. GATASE_TYPE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ4J8F7_SULAC
AccessionPrimary (citable) accession number: Q4J8F7
Entry history
Integrated into UniProtKB/TrEMBL: August 2, 2005
Last sequence update: August 2, 2005
Last modified: January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info