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Reviewed, UniProtKB/Swiss-Prot Q4J7A3 (GLPK2_SULAC)

Last modified February 9, 2010. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Glycerol kinase 2
    EC=2.7.1.30
Alternative name(s):
    ATP:glycerol 3-phosphotransferase 2
    Glycerokinase 2
      Short name=GK 2
Gene names
Name: glpK2
Ordered Locus Names: Saci_2033
OrganismSulfolobus acidocaldarius [Complete proteome] [HAMAP]
Taxonomic identifier2285 [NCBI]
Taxonomic lineageArchaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus

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Protein attributes

Sequence length497 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Key enzyme in the regulation of glycerol uptake and metabolism. HAMAP MF_00186

Catalytic activity

ATP + glycerol = ADP + sn-glycerol 3-phosphate. HAMAP MF_00186

Pathway

Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. HAMAP MF_00186

Sequence similarities

Belongs to the FGGY kinase family.

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Ontologies

Keywords
   Biological processGlycerol metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processglycerol-3-phosphate metabolic process

Inferred from electronic annotation. Source: HAMAP

   Molecular functionATP binding

Inferred from electronic annotation. Source: HAMAP

glycerol kinase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 497497Glycerol kinase 2 HAMAP MF_00186
PRO_0000059532

Regions

Nucleotide binding406 – 4105ATP By similarity

Sites

Binding site131Substrate By similarity
Binding site171ATP By similarity
Binding site831Substrate By similarity
Binding site1341Substrate By similarity
Binding site2411Substrate By similarity
Binding site2631ATP By similarity
Binding site3051ATP; via carbonyl oxygen By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q4J7A3-1 [UniParc].

Last modified August 2, 2005. Version 1.
Checksum: 8AEF78EEEF675CEB

FASTA49755,356
        10         20         30         40         50         60 
MAEKYVIAID EGTTSARAIV FDKELNILGI GQNEFTQYYP QPGYVEHSPE EIWQAQLLAI 

        70         80         90        100        110        120 
NKALEKAKID RNNILSIGIT NQRETTVMWD TRTGKPIYNA IVWQDRRTAP ITDYLKANYL 

       130        140        150        160        170        180 
RLIKDRTGLV PDPYFSASKI KWILDNIPNA REKAEKGEIK FGTIDTYLIW KLTNGKAHVT 

       190        200        210        220        230        240 
DYSNASRTML FNIRKLEWDR EILEILNIPE AILPDVKPSS EIYGYAEILN SSIPISGDAG 

       250        260        270        280        290        300 
DQQAALFGQI AFNQGDVKCT YGTGSFILLN TGSNLVSSND LLTTIAWGVG KGITYALEGS 

       310        320        330        340        350        360 
IFITGAAVQW FRDGLRAIDV SDEIEPLAGS VPDNGGVYFV PAFTGLGAPY WDPYARGLII 

       370        380        390        400        410        420 
GITRGTTKAH IARAILESMA YQTMDVLGIM QRDSGIKIDA LKVDGGASKN DLLMQFQADI 

       430        440        450        460        470        480 
LKMKVVRPKI METTSMGVAM LAGLSVGYWN SMDELKQKWK IDQVFEPKMD DEYREKLYSG 

       490 
WKEAVRRALG WAKTIGG

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References

[1]"The genome of Sulfolobus acidocaldarius, a model organism of the Crenarchaeota."
Chen L., Bruegger K., Skovgaard M., Redder P., She Q., Torarinsson E., Greve B., Awayez M., Zibat A., Klenk H.-P., Garrett R.A.
J. Bacteriol. 187:4992-4999(2005) [PubMed: 15995215] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 33909 / DSM 639 / IFO 15157 / JCM 8929 / NCIB 11770.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000077 Genomic DNA. Translation: AAY81329.1.
RefSeqYP_256622.1.

3D structure databases

SMRQ4J7A3. Positions 3-495.
ModBaseSearch...

Genome annotation databases

GeneID3474450.
GenomeReviewsGene locus Saci_2033 in contig CP000077_GR.
KEGGsai:Saci_2033.
NMPDRfig|330779.3.peg.1719.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG511469.
OMAWSLEPDD.

Enzyme and pathway databases

BioCycSACI330779:SACI_2033-MONOMER.
BRENDA2.7.1.30. 434.

Family and domain databases

HAMAPMF_00186. Glycerol_kin.
[Tree]
InterProIPR000577. Carb_kinase_FGGY.
IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
PANTHERPTHR10196. FGGY_kin. 1 hit.
PTHR10196:SF9. Glycerol_kin. 1 hit.
PfamPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR01311. glycerol_kin. 1 hit.
PROSITEPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameGLPK2_SULAC
AccessionPrimary (citable) accession number: Q4J7A3
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: August 2, 2005
Last modified: February 9, 2010
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents