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Protein

NAD-dependent alcohol dehydrogenase

Gene

adh

Organism
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi38Zinc 1; catalyticBy similarity1
Metal bindingi66Zinc 1; catalyticBy similarity1
Metal bindingi96Zinc 2By similarity1
Metal bindingi99Zinc 2By similarity1
Metal bindingi102Zinc 2By similarity1
Metal bindingi110Zinc 2By similarity1
Metal bindingi152Zinc 1; catalyticBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
NAD-dependent alcohol dehydrogenase (EC:1.1.1.1)
Gene namesi
Name:adh
Ordered Locus Names:Saci_2057
OrganismiSulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Taxonomic identifieri330779 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001018 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001607521 – 344NAD-dependent alcohol dehydrogenaseAdd BLAST344

Interactioni

Subunit structurei

Homodimer and homotetramer.By similarity

Protein-protein interaction databases

STRINGi330779.Saci_2057.

Structurei

3D structure databases

ProteinModelPortaliQ4J781.
SMRiQ4J781.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG01455. Archaea.
COG1064. LUCA.
HOGENOMiHOG000294685.
KOiK13953.
OMAiVTHEFEE.
OrthoDBiPOG093Z07SO.

Family and domain databases

Gene3Di3.90.180.10. 2 hits.
InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SMARTiView protein in SMART
SM00829. PKS_ER. 1 hit.
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4J781-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAMLLHKFG EPLRLEDMDV PKVGVGQVLV KVDYAGVCHT DLSVRSGAIF
60 70 80 90 100
NRISSSKPTL PLVIGHEIAG EVVELGGNVE GFKKSDKVLI DPWIGDGSCH
110 120 130 140 150
YCKIGEDQYC DNPKWLGINV NGGYGEYVLV PDYRYMFKLR NLSTSTASPL
160 170 180 190 200
ACSGVTAYRA LRLANLDPSK SVMIIGAGGG LGSIAVQIAK AIHGSFIIGV
210 220 230 240 250
DVSEEGLKLA TNLGADYVTS KVDEEEVRKI TTGRGVDAII DFVGSEFTTS
260 270 280 290 300
NYYTLLAKLG RYVKVGTYGG GLPHDAGLRL HSMGWQFIGT LTGNRKDFLE
310 320 330 340
VLELAENGKI KPMITKVLSL EEANDALDNL EKGKVSGRQV LKVT
Length:344
Mass (Da):37,086
Last modified:August 2, 2005 - v1
Checksum:iC67E8763B928748E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000077 Genomic DNA. Translation: AAY81351.1.
RefSeqiWP_011278853.1. NC_007181.1.

Genome annotation databases

EnsemblBacteriaiAAY81351; AAY81351; Saci_2057.
GeneIDi3473610.
KEGGisai:Saci_2057.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000077 Genomic DNA. Translation: AAY81351.1.
RefSeqiWP_011278853.1. NC_007181.1.

3D structure databases

ProteinModelPortaliQ4J781.
SMRiQ4J781.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi330779.Saci_2057.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAY81351; AAY81351; Saci_2057.
GeneIDi3473610.
KEGGisai:Saci_2057.

Phylogenomic databases

eggNOGiarCOG01455. Archaea.
COG1064. LUCA.
HOGENOMiHOG000294685.
KOiK13953.
OMAiVTHEFEE.
OrthoDBiPOG093Z07SO.

Family and domain databases

Gene3Di3.90.180.10. 2 hits.
InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SMARTiView protein in SMART
SM00829. PKS_ER. 1 hit.
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiADH_SULAC
AccessioniPrimary (citable) accession number: Q4J781
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: August 2, 2005
Last modified: April 12, 2017
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.