Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

NAD-dependent alcohol dehydrogenase

Gene

adh

Organism
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.
A secondary alcohol + NAD+ = a ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi38Zinc 1; catalyticBy similarity1
Metal bindingi66Zinc 1; catalyticBy similarity1
Metal bindingi96Zinc 2By similarity1
Metal bindingi99Zinc 2By similarity1
Metal bindingi102Zinc 2By similarity1
Metal bindingi110Zinc 2By similarity1
Metal bindingi152Zinc 1; catalyticBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
NAD-dependent alcohol dehydrogenase (EC:1.1.1.1)
Gene namesi
Name:adh
Ordered Locus Names:Saci_2057
OrganismiSulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Taxonomic identifieri330779 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001018 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001607521 – 344NAD-dependent alcohol dehydrogenaseAdd BLAST344

Proteomic databases

PRIDEiQ4J781

Interactioni

Subunit structurei

Homodimer and homotetramer.By similarity

Protein-protein interaction databases

STRINGi330779.Saci_2057

Structurei

3D structure databases

ProteinModelPortaliQ4J781
SMRiQ4J781
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG01455 Archaea
COG1064 LUCA
HOGENOMiHOG000294685
KOiK13953
OMAiGAWAEYT
OrthoDBiPOG093Z07SO

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

Q4J781-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAMLLHKFG EPLRLEDMDV PKVGVGQVLV KVDYAGVCHT DLSVRSGAIF
60 70 80 90 100
NRISSSKPTL PLVIGHEIAG EVVELGGNVE GFKKSDKVLI DPWIGDGSCH
110 120 130 140 150
YCKIGEDQYC DNPKWLGINV NGGYGEYVLV PDYRYMFKLR NLSTSTASPL
160 170 180 190 200
ACSGVTAYRA LRLANLDPSK SVMIIGAGGG LGSIAVQIAK AIHGSFIIGV
210 220 230 240 250
DVSEEGLKLA TNLGADYVTS KVDEEEVRKI TTGRGVDAII DFVGSEFTTS
260 270 280 290 300
NYYTLLAKLG RYVKVGTYGG GLPHDAGLRL HSMGWQFIGT LTGNRKDFLE
310 320 330 340
VLELAENGKI KPMITKVLSL EEANDALDNL EKGKVSGRQV LKVT
Length:344
Mass (Da):37,086
Last modified:August 2, 2005 - v1
Checksum:iC67E8763B928748E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000077 Genomic DNA Translation: AAY81351.1
RefSeqiWP_011278853.1, NC_007181.1

Genome annotation databases

EnsemblBacteriaiAAY81351; AAY81351; Saci_2057
GeneIDi3473610
KEGGisai:Saci_2057
PATRICifig|330779.12.peg.2056

Similar proteinsi

Entry informationi

Entry nameiADH_SULAC
AccessioniPrimary (citable) accession number: Q4J781
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: August 2, 2005
Last modified: May 23, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health