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Q4J6D9

- GLMS_SULAC

UniProt

Q4J6D9 - GLMS_SULAC

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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene
glmS, Saci_2364
Organism
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source By similarity.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activity By similarity
Active sitei585 – 5851For Fru-6P isomerization activity By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciSACI330779:GH9J-2321-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
Alternative name(s):
D-fructose-6-phosphate amidotransferase
GFAT
Glucosamine-6-phosphate synthase
Hexosephosphate aminotransferase
L-glutamine--D-fructose-6-phosphate amidotransferase
Gene namesi
Name:glmS
Ordered Locus Names:Saci_2364
OrganismiSulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Taxonomic identifieri330779 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000001018: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 590589Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotationPRO_0000135433Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi330779.Saci_2364.

Structurei

3D structure databases

ProteinModelPortaliQ4J6D9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 221220Glutamine amidotransferase type-2Add
BLAST
Domaini286 – 422137SIS 1Add
BLAST
Domaini445 – 580136SIS 2Add
BLAST

Sequence similaritiesi

Contains 2 SIS domains.

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258896.
KOiK00820.
OMAiSVFETQT.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF00310. GATase_2. 1 hit.
PF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4J6D9-1 [UniParc]FASTAAdd to Basket

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MCGIIGIVSS KEDKKIADKV ISALKRLEYR GYDSVGVASL DNNKLEVRKA    50
KGTVEEVISK KKVSEMSGYI FLGHTRWATH GPPTDYNAHP HVDCSGKIAV 100
IHNGTIKNYK ELREELQTLG HVFKSDTDTE IIPHLIEEFM KRGMDAYSAF 150
RNSIKTLEGS YAVLAVIHGE KRIFFAKRDN PLVIGLGEKE NYIASDIPAF 200
LSYTKRILVI KDGELGFITT SNVFIEDKDG NPVDLSDRVR VIDWDVETAS 250
KEGYPHFMIK EIHESPKSIR DTVDSLISDL DLIDKIIAEM KSSGRIVVVG 300
AGTSYHAGLY FSLLLSREGM NSFPLIASEY YNFKAKKDDL IFAISQSGET 350
LDLLQAVRKF KEEGARIVSL TNVIESALAR ESNYKIYMRA GPEISVAATK 400
TFITQLISLL FIYSRLRRDN TNKFRGADTE VERVISSVEG YAKLIGEELS 450
KKTSIYYLGR GMSLPLAMEG ALKIKEVAYV HAEAYPAGES KHGPISLVDK 500
GFPIVAINDG EITDLLRNNV IEMKARGAKA YVISANKKIS ESDVEIYLDS 550
IQFPALSISV VLQLIAYYAS VSKGLNPDKP RNLAKTVTVE 590
Length:590
Mass (Da):65,549
Last modified:January 23, 2007 - v3
Checksum:i55137A520BCC1587
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000077 Genomic DNA. Translation: AAY81643.1.
RefSeqiYP_256936.1. NC_007181.1.

Genome annotation databases

EnsemblBacteriaiAAY81643; AAY81643; Saci_2364.
GeneIDi3472798.
KEGGisai:Saci_2364.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000077 Genomic DNA. Translation: AAY81643.1 .
RefSeqi YP_256936.1. NC_007181.1.

3D structure databases

ProteinModelPortali Q4J6D9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 330779.Saci_2364.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY81643 ; AAY81643 ; Saci_2364 .
GeneIDi 3472798.
KEGGi sai:Saci_2364.

Phylogenomic databases

eggNOGi COG0449.
HOGENOMi HOG000258896.
KOi K00820.
OMAi SVFETQT.

Enzyme and pathway databases

BioCyci SACI330779:GH9J-2321-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF00310. GATase_2. 1 hit.
PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of Sulfolobus acidocaldarius, a model organism of the Crenarchaeota."
    Chen L., Bruegger K., Skovgaard M., Redder P., She Q., Torarinsson E., Greve B., Awayez M., Zibat A., Klenk H.-P., Garrett R.A.
    J. Bacteriol. 187:4992-4999(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770.

Entry informationi

Entry nameiGLMS_SULAC
AccessioniPrimary (citable) accession number: Q4J6D9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 63 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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