Reviewed, UniProtKB/Swiss-Prot Q4IPB3 (CWC27_GIBZE)

Names and origin

Protein names

Recommended name:
    Peptidyl-prolyl isomerase CWC27
    EC=5.2.1.8

Gene names

Name:	CWC27
ORF Names:	FG00945

Organism

Gibberella zeae (Wheat head blight fungus) (Fusarium graminearum)

Taxonomic identifier

5518 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Hypocreomycetidae › Hypocreales › Nectriaceae › Gibberella

Protein attributes

Sequence length	548 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in pre-mRNA splicing By similarity.
Catalytic activity	Peptidylproline (omega=180) = peptidylproline (omega=0).
Subunit structure	Associated with the spliceosome By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Sequence similarities	Belongs to the cyclophilin-type PPIase family. CWC27 subfamily. Contains 1 PPIase cyclophilin-type domain.

Ontologies

Keywords
Biological process	mRNA processing mRNA splicing
Cellular component	Cytoplasm Nucleus Spliceosome
Molecular function	Isomerase Rotamase
Gene Ontology (GO)
Biological process	RNA splicing Inferred from electronic annotation. Source: UniProtKB-KW mRNA processing Inferred from electronic annotation. Source: UniProtKB-KW protein folding Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell spliceosomal complex Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	peptidyl-prolyl cis-trans isomerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 548	548	Peptidyl-prolyl isomerase CWC27		PRO_0000064185
Regions
	Domain	11 – 193	183	PPIase cyclophilin-type

Sequences

	Sequence		Length	Mass (Da)
	Q4IPB3-1 [UniParc]. Last modified August 16, 2005. Version 1. Checksum: CD8C59B37B323541	FASTA	548	60,927
	10 20 30 40 50 60 MSAIYNLEPQ PTASVIIHTT RGELSVELFA KQAPLTCRNF LQLALDGYYD NTIFHRLVPG 70 80 90 100 110 120 FILQGGDPTG TGNGGESIYD GGAFSGDLDP WPMDQRMGKN AGPTGINFKD EFHSRLKFNR 130 140 150 160 170 180 RGLLGSANES RPDTNSSQFF FTLDTAEELN GKNTMFGRIA GDTVYNLAKM GEGEVDEATE 190 200 210 220 230 240 RPTYPVKIER IEILINPFED MKKRSRVAAV APSKTTTTKD KKKKRKGGKQ LLSFGDDEGD 250 260 270 280 290 300 DEMPVLKKKK FDPRIVMEAP EEAPEQDEVR SKPTKAKKER ASEKRVSIAQ EEQDNSDQTT 310 320 330 340 350 360 PREPPKEVRQ KPAPPVKMEI EDESPEPEAP RKTALERANE EMAALKASMR RTIHSEEPVK 370 380 390 400 410 420 EKKKSALESM IPETSMRGRK RRPGAANTSA ADDAKALRML KAFQSRLEKA PPEKENEPAA 430 440 450 460 470 480 RETTKDGEDA QAGDEEAELC DLHFIANCQS CTSWDKQEKD ESDDEGWMSH ALSFAADKLG 490 500 510 520 530 540 KDLSNRRKAE EELVVIDPRE KARTLKDEKK AARDARQGNS GRAWDQARDA ARNAKMAQAA SLAGRGAK

References

[1]

"The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization." Cuomo C.A., Gueldener U., Xu J.-R., Trail F., Turgeon B.G., Di Pietro A., Walton J.D., Ma L.-J., Baker S.E., Rep M., Adam G., Antoniw J., Baldwin T., Calvo S.E., Chang Y.-L., DeCaprio D., Gale L.R., Gnerre S. , Goswami R.S., Hammond-Kosack K., Harris L.J., Hilburn K., Kennell J.C., Kroken S., Magnuson J.K., Mannhaupt G., Mauceli E.W., Mewes H.-W., Mitterbauer R., Muehlbauer G., Muensterkoetter M., Nelson D., O'Donnell K., Ouellet T., Qi W., Quesneville H., Roncero M.I.G., Seong K.-Y., Tetko I.V., Urban M., Waalwijk C., Ward T.J., Yao J., Birren B.W., Kistler H.C. Science 317:1400-1402(2007) [PubMed: 17823352] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PH-1 / FGSC 9075 / NRRL 31084.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACM01000046 Genomic DNA. Translation: EAA69496.1.
RefSeq	XP_381121.1.
3D structure databases
SMR	Q4IPB3. Positions 6-199.
ModBase	Search...
Genome annotation databases
GeneID	2783469.
KEGG	fgr:FG00945.1.
Phylogenomic databases
eggNOG	fuNOG06026.
PhylomeDB	Q4IPB3.
Enzyme and pathway databases
BRENDA	5.2.1.8. 74326.
Family and domain databases
InterPro	IPR015891. Cyclophilin-like. IPR020892. Pep-Pro_Isoase_cyclophilin_CS. IPR002130. PPIase_cyclophilin. [Graphical view]
Gene3D	G3DSA:2.40.100.10. PPIase_cyclophilin. 1 hit.
Pfam	PF00160. Pro_isomerase. 1 hit. [Graphical view]
PRINTS	PR00153. CSAPPISMRASE.
PROSITE	PS00170. CSA_PPIASE_1. 1 hit. PS50072. CSA_PPIASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CWC27_GIBZE

Accession

Primary (citable) accession number: Q4IPB3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	August 16, 2005
Last modified:	January 19, 2010
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)