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Protein

FK506-binding protein 2

Gene

FPR2

Organism
Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084) (Wheat head blight fungus) (Fusarium graminearum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulationi

Inhibited by both FK506 and rapamycin.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Names & Taxonomyi

Protein namesi
Recommended name:
FK506-binding protein 2 (EC:5.2.1.8)
Alternative name(s):
Peptidyl-prolyl cis-trans isomerase
Short name:
PPIase
Rotamase
Gene namesi
Name:FPR2
ORF Names:FGRRES_01408, FGSG_01408
OrganismiGibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084) (Wheat head blight fungus) (Fusarium graminearum)
Taxonomic identifieri229533 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesNectriaceaeFusarium
Proteomesi
  • UP000070720 Componenti: Chromosome 1
  • UP000009057 Componenti: Unplaced

Organism-specific databases

EuPathDBiFungiDB:FGSG_01408.

Subcellular locationi

  • Endoplasmic reticulum PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000023306920 – 195FK506-binding protein 2Add BLAST176

Interactioni

Protein-protein interaction databases

STRINGi229533.XP_381584.1.

Structurei

3D structure databases

ProteinModelPortaliQ4IN00.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 127PPIase FKBP-typePROSITE-ProRule annotationAdd BLAST89

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi192 – 195Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Contains 1 PPIase FKBP-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0549. Eukaryota.
COG0545. LUCA.
InParanoidiQ4IN00.
KOiK09569.
OrthoDBiEOG092C52SD.

Family and domain databases

InterProiIPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00254. FKBP_C. 1 hit.
[Graphical view]
PROSITEiPS00014. ER_TARGET. 1 hit.
PS50059. FKBP_PPIASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4IN00-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAALFLSAL ASTAVGVVAE ELKIDVTLPV ICERKTQKGD GVHMHYRGTL
60 70 80 90 100
KDSGKQFDAS YDRGTPLSFK VGAGQVIKGW DEGLLDMCIG EKRVLTIPPE
110 120 130 140 150
FGYGQRAIGP IPAGSTLVFE TELVGIDGVP KPEKIETKVV EGAESAAEAI
160 170 180 190
SEATEAAATA SQKVAGKVAE AIVDAAKAAK TIIADTDDAP EHEEL
Length:195
Mass (Da):20,421
Last modified:April 18, 2006 - v2
Checksum:i4CDDCC233DFCBF51
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS231663 Genomic DNA. Translation: ESU06720.1.
HG970332 Genomic DNA. Translation: CEF73535.1.
RefSeqiXP_011317205.1. XM_011318903.1.

Genome annotation databases

GeneIDi23548849.
KEGGifgr:FGSG_01408.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS231663 Genomic DNA. Translation: ESU06720.1.
HG970332 Genomic DNA. Translation: CEF73535.1.
RefSeqiXP_011317205.1. XM_011318903.1.

3D structure databases

ProteinModelPortaliQ4IN00.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi229533.XP_381584.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi23548849.
KEGGifgr:FGSG_01408.

Organism-specific databases

EuPathDBiFungiDB:FGSG_01408.

Phylogenomic databases

eggNOGiKOG0549. Eukaryota.
COG0545. LUCA.
InParanoidiQ4IN00.
KOiK09569.
OrthoDBiEOG092C52SD.

Family and domain databases

InterProiIPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00254. FKBP_C. 1 hit.
[Graphical view]
PROSITEiPS00014. ER_TARGET. 1 hit.
PS50059. FKBP_PPIASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFKBP2_GIBZE
AccessioniPrimary (citable) accession number: Q4IN00
Secondary accession number(s): A0A098D520, A0A0E0RQL0, V6R4C2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: April 18, 2006
Last modified: November 30, 2016
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.