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Q4IEV4

- ESA1_GIBZE

UniProt

Q4IEV4 - ESA1_GIBZE

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Protein

Histone acetyltransferase ESA1

Gene
ESA1, FGSG_04254
Organism
Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084) (Wheat head blight fungus) (Fusarium graminearum)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, histone H2B to form H2BK16ac, and histone H2A to form H2AK4ac and H2AK7ac. Acetylation of histone H4 is essential for DNA double-strand break repair through homologous recombination. Involved in cell cycle progression. Recruitment to promoters depends on H3K4me By similarity.

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei316 – 3161 By similarity
Active sitei358 – 3581Nucleophile By similarity
Binding sitei361 – 3611Acetyl-CoA By similarity
Binding sitei396 – 3961Acetyl-CoA By similarity

GO - Molecular functioni

  1. H4 histone acetyltransferase activity Source: EnsemblFungi

GO - Biological processi

  1. chromatin silencing at rDNA Source: EnsemblFungi
  2. DNA repair Source: EnsemblFungi
  3. DNA-templated transcription, elongation Source: EnsemblFungi
  4. positive regulation of transcription elongation from RNA polymerase II promoter Source: EnsemblFungi
  5. regulation of cell cycle Source: EnsemblFungi
  6. regulation of transcription by chromatin organization Source: EnsemblFungi
Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase ESA1 (EC:2.3.1.48)
Gene namesi
Name:ESA1
ORF Names:FGSG_04254
OrganismiGibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084) (Wheat head blight fungus) (Fusarium graminearum)
Taxonomic identifieri229533 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesNectriaceaeFusarium
ProteomesiUP000009057: Chromosome 2

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. Piccolo NuA4 histone acetyltransferase complex Source: EnsemblFungi
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 502502Histone acetyltransferase ESA1PRO_0000051557Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei316 – 3161N6-acetyllysine; by autocatalysis By similarity

Post-translational modificationi

Autoacetylation at Lys-316 is required for proper function By similarity.

Keywords - PTMi

Acetylation

Interactioni

Subunit structurei

Component of the NuA4 histone acetyltransferase complex By similarity.

Protein-protein interaction databases

STRINGi5518.FG04254.1.

Structurei

3D structure databases

ProteinModelPortaliQ4IEV4.
SMRiQ4IEV4. Positions 216-491.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni366 – 3727Acetyl-CoA binding By similarity

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi299 – 32022ESA1-RPD3 motif By similarityAdd
BLAST

Domaini

The ESA1-RPD3 motif is common to ESA1 and RPD3 and is required for ESA1 histone acetyl-transferase (HAT) activity and RPD3 histone deacetylase (HDAC) activity.

Sequence similaritiesi

Belongs to the MYST (SAS/MOZ) family.

Phylogenomic databases

eggNOGiCOG5027.
KOiK11304.
OrthoDBiEOG7RFTRR.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000953. Chromo_domain/shadow.
IPR016197. Chromodomain-like.
IPR002717. MOZ_SAS.
IPR025995. Tudor-knot.
[Graphical view]
PfamiPF01853. MOZ_SAS. 1 hit.
PF11717. Tudor-knot. 1 hit.
[Graphical view]
SMARTiSM00298. CHROMO. 1 hit.
[Graphical view]
SUPFAMiSSF54160. SSF54160. 1 hit.
SSF55729. SSF55729. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4IEV4-1 [UniParc]FASTAAdd to Basket

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MAGGTPGGEP TVGSGEPRLK SLATPETIKT GCIAWVEKEG QPRRAEILSI    50
KTTKSGKQFY CNFDNFNKRL DEWVPVIRLD FTREVEWPNP EKEKPKDPKA 100
KKAPTVQSKK TQPSKKSQKR PSKREQSTTS EANTPHPWTD FVENQNRQKS 150
ASIGPDGDSQ ARASVDGGET PGGGDEMEVD ERETEVKREP AEFSREVEIE 200
KLRTSGSMTQ NPTEVSRIRN ISKVQFGRFD LYPWYFSPYP EIFSQEDVIF 250
ICEFCLSYYG DLKAFTRHRK KCTLQHPPGN ELYRNEEISF FEIDGRRQRT 300
WCRNLCLLSK MFLDHKTLYY DVDPFLFYVM TVRTEKGCHM VGYFSKEKES 350
ADGYNVACIL TMPQYQRKGY GRLLIQFSYE LSRIEGKLGS PEKPLSDLGL 400
LSYRQYWSEN ILEFLMGYNE RDEKVTIEAI STALAMTTQD VEHTLQALRM 450
QVYHKSDHKI VIPEKLIEQR EKTKLKRKRT VDPTKIQWKP PVFTASSRTW 500
GW 502
Length:502
Mass (Da):58,095
Last modified:August 16, 2005 - v1
Checksum:i61DCF761F2C3CD43
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS231664 Genomic DNA. Translation: ESU08867.1.
RefSeqiXP_384430.1. XM_384430.1.

Genome annotation databases

EnsemblFungiiFGSG_04254T0; FGSG_04254P0; FGSG_04254.
GeneIDi2786341.
KEGGifgr:FG04254.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS231664 Genomic DNA. Translation: ESU08867.1 .
RefSeqi XP_384430.1. XM_384430.1.

3D structure databases

ProteinModelPortali Q4IEV4.
SMRi Q4IEV4. Positions 216-491.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5518.FG04254.1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii FGSG_04254T0 ; FGSG_04254P0 ; FGSG_04254 .
GeneIDi 2786341.
KEGGi fgr:FG04254.1.

Phylogenomic databases

eggNOGi COG5027.
KOi K11304.
OrthoDBi EOG7RFTRR.

Family and domain databases

Gene3Di 3.40.630.30. 1 hit.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR000953. Chromo_domain/shadow.
IPR016197. Chromodomain-like.
IPR002717. MOZ_SAS.
IPR025995. Tudor-knot.
[Graphical view ]
Pfami PF01853. MOZ_SAS. 1 hit.
PF11717. Tudor-knot. 1 hit.
[Graphical view ]
SMARTi SM00298. CHROMO. 1 hit.
[Graphical view ]
SUPFAMi SSF54160. SSF54160. 1 hit.
SSF55729. SSF55729. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084.
  2. "Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium."
    Ma L.-J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.-J., Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B., Houterman P.M., Kang S., Shim W.-B., Woloshuk C., Xie X., Xu J.-R., Antoniw J., Baker S.E.
    , Bluhm B.H., Breakspear A., Brown D.W., Butchko R.A.E., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.J., Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E., Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M., Kumar L., Lee Y.-H., Li L., Manners J.M., Miranda-Saavedra D., Mukherjee M., Park G., Park J., Park S.-Y., Proctor R.H., Regev A., Ruiz-Roldan M.C., Sain D., Sakthikumar S., Sykes S., Schwartz D.C., Turgeon B.G., Wapinski I., Yoder O., Young S., Zeng Q., Zhou S., Galagan J., Cuomo C.A., Kistler H.C., Rep M.
    Nature 464:367-373(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084.

Entry informationi

Entry nameiESA1_GIBZE
AccessioniPrimary (citable) accession number: Q4IEV4
Secondary accession number(s): V6R4L8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: August 16, 2005
Last modified: June 11, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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