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Protein

Protein OS-9 homolog

Gene

YOS1

Organism
Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084) (Wheat head blight fungus) (Fusarium graminearum)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei171 – 1711CarbohydrateBy similarity
Binding sitei242 – 2421CarbohydrateBy similarity
Binding sitei248 – 2481CarbohydrateBy similarity
Binding sitei270 – 2701CarbohydrateBy similarity
Binding sitei276 – 2761CarbohydrateBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Protein OS-9 homolog
Gene namesi
Name:YOS1
ORF Names:FGSG_04451
OrganismiGibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084) (Wheat head blight fungus) (Fusarium graminearum)
Taxonomic identifieri229533 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesNectriaceaeFusarium

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 512495Protein OS-9 homologPRO_0000043271Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi118 – 1181N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi151 ↔ 164By similarity
Disulfide bondi241 ↔ 274By similarity
Disulfide bondi256 ↔ 286By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Interacts with missfolded ER lumenal proteins.By similarity

Protein-protein interaction databases

STRINGi5518.FGSG_04451P0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini149 – 23890PRKCSHAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi509 – 5124Prevents secretion from ERPROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the OS-9 family.Curated
Contains 1 PRKCSH domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG309879.
InParanoidiQ4IEA7.
KOiK10088.
OrthoDBiEOG7R2BVR.

Family and domain databases

InterProiIPR012913. PRKCSH.
[Graphical view]
PfamiPF07915. PRKCSH. 1 hit.
[Graphical view]
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4IEA7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRFNLILLA SLQLVGARSP GGFNIHEDLL TYPQFEVVFD NQYISEKDAH
60 70 80 90 100
SLLDSQHPTY SADFAQSTLG QAREADARDN EAENKDQDGP SYKYELMKMP
110 120 130 140 150
PNEYLCSIPI LQSPEAENKT ANELAKAEEA RELTRATASG WELLSELQDS
160 170 180 190 200
CLYFMSGWWS YSFCNNREIV QFHALPSIPN GQPPKRDPHT MEFTLGRVPA
210 220 230 240 250
VPASAAHQAK MNGQEAPPPA ELQVKGDQRY LVQRLEGGTI CDLTGRERTI
260 270 280 290 300
EVQYHCVPGM KADRIGWIKE VTICAYLMVV NTPRLCNDVA FLPPEETRAN
310 320 330 340 350
PITCKLILDK LNEPPSLDQT VPLAQDEAQV PLKQEDTGAK SGDAAPRDVG
360 370 380 390 400
KEPINIGGVL VGARNVLSGA DEAGKPPAKL PPPRSYFSNS NTDTERFLKV
410 420 430 440 450
VASGKSKEDG GEMEVLGNEE LEKLDLKPSV VKDMTERMRK LAGKYGWKLE
460 470 480 490 500
LVELPGGEKE LRGYIDADEE ELAKNKAKLK KEKEAAAKAK GDDEEEVVEG
510
SEEQFFDKKD EL
Length:512
Mass (Da):56,835
Last modified:August 16, 2005 - v1
Checksum:i906486CB245D2D24
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS231664 Genomic DNA. Translation: ESU08650.1.

Genome annotation databases

KEGGifgr:FG04451.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS231664 Genomic DNA. Translation: ESU08650.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5518.FGSG_04451P0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGifgr:FG04451.1.

Phylogenomic databases

eggNOGiNOG309879.
InParanoidiQ4IEA7.
KOiK10088.
OrthoDBiEOG7R2BVR.

Family and domain databases

InterProiIPR012913. PRKCSH.
[Graphical view]
PfamiPF07915. PRKCSH. 1 hit.
[Graphical view]
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084.
  2. "Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium."
    Ma L.-J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.-J., Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B., Houterman P.M., Kang S., Shim W.-B., Woloshuk C., Xie X., Xu J.-R., Antoniw J., Baker S.E.
    , Bluhm B.H., Breakspear A., Brown D.W., Butchko R.A.E., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.J., Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E., Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M., Kumar L., Lee Y.-H., Li L., Manners J.M., Miranda-Saavedra D., Mukherjee M., Park G., Park J., Park S.-Y., Proctor R.H., Regev A., Ruiz-Roldan M.C., Sain D., Sakthikumar S., Sykes S., Schwartz D.C., Turgeon B.G., Wapinski I., Yoder O., Young S., Zeng Q., Zhou S., Galagan J., Cuomo C.A., Kistler H.C., Rep M.
    Nature 464:367-373(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084.

Entry informationi

Entry nameiOS9_GIBZE
AccessioniPrimary (citable) accession number: Q4IEA7
Secondary accession number(s): V6R9V7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: August 16, 2005
Last modified: June 24, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.