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Protein

Protein OS-9 homolog

Gene

YOS1

Organism
Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084) (Wheat head blight fungus) (Fusarium graminearum)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei171CarbohydrateBy similarity1
Binding sitei242CarbohydrateBy similarity1
Binding sitei248CarbohydrateBy similarity1
Binding sitei270CarbohydrateBy similarity1
Binding sitei276CarbohydrateBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Protein OS-9 homolog
Gene namesi
Name:YOS1
ORF Names:FGRRES_04451, FGSG_04451
OrganismiGibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084) (Wheat head blight fungus) (Fusarium graminearum)
Taxonomic identifieri229533 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesNectriaceaeFusarium
Proteomesi
  • UP000070720 Componenti: Chromosome 2
  • UP000009057 Componenti: Unplaced

Organism-specific databases

EuPathDBiFungiDB:FGSG_04451.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000004327118 – 512Protein OS-9 homologAdd BLAST495

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi118N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi151 ↔ 164By similarity
Disulfide bondi241 ↔ 274By similarity
Disulfide bondi256 ↔ 286By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Interacts with missfolded ER lumenal proteins.By similarity

Protein-protein interaction databases

STRINGi229533.XP_384627.1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini149 – 238PRKCSHAdd BLAST90

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi509 – 512Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the OS-9 family.Curated
Contains 1 PRKCSH domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3394. Eukaryota.
ENOG410XR8A. LUCA.
InParanoidiQ4IEA7.
KOiK10088.
OrthoDBiEOG092C4FPG.

Family and domain databases

InterProiIPR012913. PRKCSH.
[Graphical view]
PfamiPF07915. PRKCSH. 1 hit.
[Graphical view]
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4IEA7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRFNLILLA SLQLVGARSP GGFNIHEDLL TYPQFEVVFD NQYISEKDAH
60 70 80 90 100
SLLDSQHPTY SADFAQSTLG QAREADARDN EAENKDQDGP SYKYELMKMP
110 120 130 140 150
PNEYLCSIPI LQSPEAENKT ANELAKAEEA RELTRATASG WELLSELQDS
160 170 180 190 200
CLYFMSGWWS YSFCNNREIV QFHALPSIPN GQPPKRDPHT MEFTLGRVPA
210 220 230 240 250
VPASAAHQAK MNGQEAPPPA ELQVKGDQRY LVQRLEGGTI CDLTGRERTI
260 270 280 290 300
EVQYHCVPGM KADRIGWIKE VTICAYLMVV NTPRLCNDVA FLPPEETRAN
310 320 330 340 350
PITCKLILDK LNEPPSLDQT VPLAQDEAQV PLKQEDTGAK SGDAAPRDVG
360 370 380 390 400
KEPINIGGVL VGARNVLSGA DEAGKPPAKL PPPRSYFSNS NTDTERFLKV
410 420 430 440 450
VASGKSKEDG GEMEVLGNEE LEKLDLKPSV VKDMTERMRK LAGKYGWKLE
460 470 480 490 500
LVELPGGEKE LRGYIDADEE ELAKNKAKLK KEKEAAAKAK GDDEEEVVEG
510
SEEQFFDKKD EL
Length:512
Mass (Da):56,835
Last modified:August 16, 2005 - v1
Checksum:i906486CB245D2D24
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS231664 Genomic DNA. Translation: ESU08650.1.
HG970333 Genomic DNA. Translation: CEF79464.1.
RefSeqiXP_011321149.1. XM_011322847.1.

Genome annotation databases

GeneIDi23551702.
KEGGifgr:FGSG_04451.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS231664 Genomic DNA. Translation: ESU08650.1.
HG970333 Genomic DNA. Translation: CEF79464.1.
RefSeqiXP_011321149.1. XM_011322847.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi229533.XP_384627.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi23551702.
KEGGifgr:FGSG_04451.

Organism-specific databases

EuPathDBiFungiDB:FGSG_04451.

Phylogenomic databases

eggNOGiKOG3394. Eukaryota.
ENOG410XR8A. LUCA.
InParanoidiQ4IEA7.
KOiK10088.
OrthoDBiEOG092C4FPG.

Family and domain databases

InterProiIPR012913. PRKCSH.
[Graphical view]
PfamiPF07915. PRKCSH. 1 hit.
[Graphical view]
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOS9_GIBZE
AccessioniPrimary (citable) accession number: Q4IEA7
Secondary accession number(s): A0A098DKG9, A0A0E0S7I9, V6R9V7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: August 16, 2005
Last modified: November 30, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.