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Q4IEA7

- OS9_GIBZE

UniProt

Q4IEA7 - OS9_GIBZE

Protein

Protein OS-9 homolog

Gene

YOS1

Organism
Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084) (Wheat head blight fungus) (Fusarium graminearum)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (16 Aug 2005)
      Previous versions | rss
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    Functioni

    Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei171 – 1711CarbohydrateBy similarity
    Binding sitei242 – 2421CarbohydrateBy similarity
    Binding sitei248 – 2481CarbohydrateBy similarity
    Binding sitei270 – 2701CarbohydrateBy similarity
    Binding sitei276 – 2761CarbohydrateBy similarity

    Keywords - Ligandi

    Lectin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein OS-9 homolog
    Gene namesi
    Name:YOS1
    ORF Names:FGSG_04451
    OrganismiGibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084) (Wheat head blight fungus) (Fusarium graminearum)
    Taxonomic identifieri229533 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesNectriaceaeFusarium
    ProteomesiUP000009057: Chromosome 2

    Subcellular locationi

    Endoplasmic reticulum membrane PROSITE-ProRule annotation; Peripheral membrane protein By similarity; Lumenal side By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 512495Protein OS-9 homologPRO_0000043271Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi118 – 1181N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi151 ↔ 164By similarity
    Disulfide bondi241 ↔ 274By similarity
    Disulfide bondi256 ↔ 286By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Interactioni

    Subunit structurei

    Interacts with missfolded ER lumenal proteins.By similarity

    Protein-protein interaction databases

    STRINGi5518.FG04451.1.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini149 – 23890PRKCSHAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi509 – 5124Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the OS-9 family.Curated
    Contains 1 PRKCSH domain.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG309879.
    KOiK10088.
    OrthoDBiEOG7R2BVR.

    Family and domain databases

    InterProiIPR012913. PRKCSH.
    [Graphical view]
    PfamiPF07915. PRKCSH. 1 hit.
    [Graphical view]
    PROSITEiPS00014. ER_TARGET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q4IEA7-1 [UniParc]FASTAAdd to Basket

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    MRRFNLILLA SLQLVGARSP GGFNIHEDLL TYPQFEVVFD NQYISEKDAH    50
    SLLDSQHPTY SADFAQSTLG QAREADARDN EAENKDQDGP SYKYELMKMP 100
    PNEYLCSIPI LQSPEAENKT ANELAKAEEA RELTRATASG WELLSELQDS 150
    CLYFMSGWWS YSFCNNREIV QFHALPSIPN GQPPKRDPHT MEFTLGRVPA 200
    VPASAAHQAK MNGQEAPPPA ELQVKGDQRY LVQRLEGGTI CDLTGRERTI 250
    EVQYHCVPGM KADRIGWIKE VTICAYLMVV NTPRLCNDVA FLPPEETRAN 300
    PITCKLILDK LNEPPSLDQT VPLAQDEAQV PLKQEDTGAK SGDAAPRDVG 350
    KEPINIGGVL VGARNVLSGA DEAGKPPAKL PPPRSYFSNS NTDTERFLKV 400
    VASGKSKEDG GEMEVLGNEE LEKLDLKPSV VKDMTERMRK LAGKYGWKLE 450
    LVELPGGEKE LRGYIDADEE ELAKNKAKLK KEKEAAAKAK GDDEEEVVEG 500
    SEEQFFDKKD EL 512
    Length:512
    Mass (Da):56,835
    Last modified:August 16, 2005 - v1
    Checksum:i906486CB245D2D24
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS231664 Genomic DNA. Translation: ESU08650.1.
    RefSeqiXP_384627.1. XM_384627.1.

    Genome annotation databases

    EnsemblFungiiFGSG_04451T0; FGSG_04451P0; FGSG_04451.
    GeneIDi2785678.
    KEGGifgr:FG04451.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS231664 Genomic DNA. Translation: ESU08650.1 .
    RefSeqi XP_384627.1. XM_384627.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5518.FG04451.1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii FGSG_04451T0 ; FGSG_04451P0 ; FGSG_04451 .
    GeneIDi 2785678.
    KEGGi fgr:FG04451.1.

    Phylogenomic databases

    eggNOGi NOG309879.
    KOi K10088.
    OrthoDBi EOG7R2BVR.

    Family and domain databases

    InterProi IPR012913. PRKCSH.
    [Graphical view ]
    Pfami PF07915. PRKCSH. 1 hit.
    [Graphical view ]
    PROSITEi PS00014. ER_TARGET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084.
    2. "Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium."
      Ma L.-J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.-J., Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B., Houterman P.M., Kang S., Shim W.-B., Woloshuk C., Xie X., Xu J.-R., Antoniw J., Baker S.E.
      , Bluhm B.H., Breakspear A., Brown D.W., Butchko R.A.E., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.J., Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E., Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M., Kumar L., Lee Y.-H., Li L., Manners J.M., Miranda-Saavedra D., Mukherjee M., Park G., Park J., Park S.-Y., Proctor R.H., Regev A., Ruiz-Roldan M.C., Sain D., Sakthikumar S., Sykes S., Schwartz D.C., Turgeon B.G., Wapinski I., Yoder O., Young S., Zeng Q., Zhou S., Galagan J., Cuomo C.A., Kistler H.C., Rep M.
      Nature 464:367-373(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084.

    Entry informationi

    Entry nameiOS9_GIBZE
    AccessioniPrimary (citable) accession number: Q4IEA7
    Secondary accession number(s): V6R9V7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: August 16, 2005
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3