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Protein

Helicase SWR1

Gene

SWR1

Organism
Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084) (Wheat head blight fungus) (Fusarium graminearum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi836 – 843ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Chromatin regulator, DNA-binding, Helicase, Hydrolase
Biological processTranscription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Helicase SWR1 (EC:3.6.4.12)
Gene namesi
Name:SWR1
ORF Names:FGRRES_05751, FGSG_05751
OrganismiGibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084) (Wheat head blight fungus) (Fusarium graminearum)
Taxonomic identifieri229533 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesNectriaceaeFusarium
Proteomesi
  • UP000070720 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiFungiDB:FGRAMPH1_01G18675.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000743691 – 1691Helicase SWR1Add BLAST1691

Proteomic databases

PRIDEiQ4IAK7.

Interactioni

Subunit structurei

Component of the SWR1 chromatin-remodeling complex.By similarity

Protein-protein interaction databases

STRINGi229533.XP_385927.1.

Structurei

3D structure databases

ProteinModelPortaliQ4IAK7.
SMRiQ4IAK7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini335 – 409HSAPROSITE-ProRule annotationAdd BLAST75
Domaini823 – 988Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST166
Domaini1375 – 1525Helicase C-terminalPROSITE-ProRule annotationAdd BLAST151

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi939 – 942DEAH box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi472 – 526Asp-richAdd BLAST55
Compositional biasi597 – 691Glu-richAdd BLAST95

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0388. Eukaryota.
ENOG410XP0A. LUCA.
InParanoidiQ4IAK7.
KOiK11681.
OrthoDBiEOG092C1YH4.

Family and domain databases

InterProiView protein in InterPro
IPR002464. DNA/RNA_helicase_DEAH_CS.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR014012. HSA_dom.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
PfamiView protein in Pfam
PF00271. Helicase_C. 1 hit.
PF00176. SNF2_N. 1 hit.
SMARTiView protein in SMART
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiView protein in PROSITE
PS00690. DEAH_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51204. HSA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4IAK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPETASTANV LPKSDPDAIK TEQDALEGYE NGGDALQGTM DGHVETNGDA
60 70 80 90 100
PATENHHEPN HIHDDERPAK RRRTRDSTPP QNTPKKMKPV SPPWKKISAD
110 120 130 140 150
GPTSYTENGR RKSGRINTLL PEPSPLSKSR TSKRSTGANS NTKTEIHLTN
160 170 180 190 200
GNSRKMPNGS HKASPATKAP SKQAPASTPK SASKKPTETR TSSRSTRRRS
210 220 230 240 250
PTPPPPPKNS TRSRRSARFS DAVIKDEAVQ DSRTATSNST NRSPRIKLRV
260 270 280 290 300
GRSGHIPLVH PGQVRKRPKI GTSFEDFWTR AGDIPVEEGG LQASEDGPQY
310 320 330 340 350
TDELAERDAR VILRVEKEVE DGGMLSQGRC SIFLPEPAEE PPRQWARQDH
360 370 380 390 400
MVKAMTNFRK LMLAEQQRHR IAAKKVAEAC RDEWLRRQPK SEEEIEAEQR
410 420 430 440 450
AVWISRYRIV AKTLFGTWEN VRTEVNRRRL AEWEQEEQRR VKAALNEAVN
460 470 480 490 500
LSEQKLQARQ AGLDSEQLSE EDGFDDLSDD MSMADDDELG LASGEDEDDE
510 520 530 540 550
DGDADSDIMS SDEEEGDEED QKDIGDENLT QEQLRAKYAH IPELEKPSTE
560 570 580 590 600
TPVTEPTPKD TDAVDTAQAT ATENAETSDE SVDMDDDMGS TDMDSDEEDE
610 620 630 640 650
EEESEEESDE DAGGLLGLLF GKSELKKMNS EAVAETPADS KEDSEMPDVE
660 670 680 690 700
AVSDGEGAEE NEMSLIQMPD PEPHESGALE KSTKEAVEEK EQIPAAMQDV
710 720 730 740 750
AAGQDGLSNT DNNVQEPASQ DNDVAMTGND PEEPSALTFE KPHSPATEPA
760 770 780 790 800
TNPPSRVHST SPPATSETKP SELDTASTEE MAVDKHDTSR SPSPQPSNHK
810 820 830 840 850
IEVPFLLRGT LREYQRDGLD WLAGLYANST NGILADEMGL GKTIQTIALL
860 870 880 890 900
AHLACTHEVW GPHLVIVPTS VMLNWEMEFK KWCPGFKILA YYGSQEERKR
910 920 930 940 950
KRQGWNNDDI WNVCITSYQL VLQDQQVFKR RRWHYMILDE AHNIKNFKSQ
960 970 980 990 1000
RWQTLLGFNT QARLLLTGTP LQNNLTELWS LLFFLMPAEN GVGGFADLQE
1010 1020 1030 1040 1050
FHDWFAKPES QILESGREQM DDEARAIISK LHKVLRPYLL RRLKADVEKQ
1060 1070 1080 1090 1100
MPAKYEHVEF CRLSKRQREL YDGFLSRTDT KETLNSGNYL SIINCLMQLR
1110 1120 1130 1140 1150
KVCNHPDLFV DRPIMTSFRM QKSVVSDFEV TEQRVQRLLH DPSPMKDVSL
1160 1170 1180 1190 1200
GFLNLMPTQC ESLSTTQAER ISQLSSHRKL MELREAQKIR AQSAHANLDP
1210 1220 1230 1240 1250
STVASNIGYL ESGARWGRYE ELQHCVYLNA LRRQKKPIYG KNLIELLTIG
1260 1270 1280 1290 1300
TDKRPYKPRP KIPRQVLAWF EEESTLVQSM IPTVNQRADS FKTIIEKFSC
1310 1320 1330 1340 1350
VTPAVVTRDM EQFVLGRKGI EAFSDEDLKL SAPVRWAPFL PKEAPPDPWH
1360 1370 1380 1390 1400
EGRMRLSIQF PDKRLLQYDC GKLQILDKLL RKLQAGGHRA LIFTQMTKVL
1410 1420 1430 1440 1450
DILEQFLNIH GHKYLRLDGA TKVEQRQILT DRFNNDPRIL CFILSTRSGG
1460 1470 1480 1490 1500
LGINLTGADT VIFYDQDWNP AMDKQCQDRC HRIGQTRDVH IYRLVSEHTI
1510 1520 1530 1540 1550
EANILRKASQ KQMLDDVVIQ EGEFTTDYFN KLSVRDVLSE KLDSKSEGLD
1560 1570 1580 1590 1600
AADAALDRVL GGPDTNNDQR RVGRALEQAE DREDVAAARV AEKEIQADDA
1610 1620 1630 1640 1650
DFTEKPSNNA SGTSTARQGT PAGKSVLDGG LDDIDAPHVE EVLEYNAWGD
1660 1670 1680 1690
KMHTIDDYML GIMAEQLKDT KLELPKDKKK GKKKGKDTRK R
Length:1,691
Mass (Da):190,422
Last modified:August 16, 2005 - v1
Checksum:iCB6C314827589965
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS231665 Genomic DNA. Translation: ESU11758.1.
HG970334 Genomic DNA. Translation: CEF87066.1.
RefSeqiXP_011324334.1. XM_011326032.1.

Genome annotation databases

GeneIDi23552917.
KEGGifgr:FGSG_05751.

Similar proteinsi

Entry informationi

Entry nameiSWR1_GIBZE
AccessioniPrimary (citable) accession number: Q4IAK7
Secondary accession number(s): A0A0E0SKV3, V6RAW2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: August 16, 2005
Last modified: July 5, 2017
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families